Department of Genetics and Developmental Biology
I am interested in uncovering the genetic networks for midbrain DA (mDA) neuron development. mDA neurons are derived from the floor plate of the ventral midbrain, and that they are of glial origin. Under the influence of Shh, FGF8 and Wnt signaling during embryonic development, transcription factors unique to the mDA progenitors are expressed, and later turn on proneural genes. My focus is to find out the essential genes for specifying mDA neurons, and untangle their genetic network.