Publications (103) View all
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Article: Images in Endocrine Pathology: Psammomatoid Calcifications in Oncocytic Neoplasms of the Thyroid, a Potential Pitfall for Papillary Carcinoma.
Endocrine Pathology 04/2013; · 1.36 Impact Factor -
Article: Floor-of-Mouth Dermoid Cysts: Report of 3 Variants and a Suggested Change in Terminology.
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ABSTRACT: PURPOSE: Dermoid cyst is a frequently used descriptive term, but its definition changes according to the clinician (eg, dermatologists, neurologists, gynecologists, oral and maxillofacial surgeons, and plastic surgeons). It is sometimes used synonymously with teratoma. In oral and maxillofacial surgery, it is applied to describe congenital floor-of-mouth cysts of 3 histologic types: epidermoid, dermoid, and teratoid. This terminology is confusing and has led to some ambiguity in the literature. The purpose of this report is to document 3 cases illustrating the utility of a more specific term, congenital germline fusion cyst of the floor of the mouth. PATIENTS AND METHODS: Patients who presented with floor-of-mouth swelling were evaluated by history, clinical examination, and imaging studies (magnetic resonance imaging and computed tomography). RESULTS: Three cases (1 epidermoid variant, 1 dermoid variant, and 1 teratoid variant) are documented to illustrate the new terminology. CONCLUSION: Congenital germline fusion cyst is more reflective of the embryologic origins of the lesion than dermoid cyst and is inclusive of all 3 histologic variants.Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons 02/2013; · 1.58 Impact Factor -
Article: Castleman disease presenting in the neck: Report of a case and review of the literature.
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ABSTRACT: Castleman disease is a rare lymphoproliferative disorder with two primary subtypes that vary in presentation and course. Unicentric Castleman disease (UCD) presents as a solitary mass, most commonly in the mediastinum, and rarely in the head and neck. In contrast to multicentric Castleman disease (MCD), which features peripheral lymphadenopathy and numerous systemic symptoms, UCD is not typically associated with generalized symptoms. Here, we present an unusual case of UCD presenting as a slowly expanding, isolated neck mass in a 29-year-old woman. This case demonstrates the distinguishing clinical, radiologic, and histologic findings unique to UCD, which is often misdiagnosed as lymphoma or other malignant process. These findings stand in contrast to those observed in MCD patients, and hence, offer insight into the practical aspects of diagnosis and management of Castleman disease in the head and neck.American journal of otolaryngology 01/2013; · 0.77 Impact Factor -
Article: Pathology quiz case 2.
Archives of otolaryngology--head & neck surgery 11/2012; 138(11):1093. · 1.92 Impact Factor -
Article: Association of CD1a-positive dendritic cells with papillary thyroid carcinoma in thyroid fine-needle aspirations: A cytologic and immunocytochemical evaluation.
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ABSTRACT: BACKGROUND: In contrast to other primary thyroid neoplasms and benign thyroid tissue, it has been demonstrated histologically that dendritic cells (DCs) are associated with papillary thyroid carcinoma (PTC). However, the presence and potential diagnostic value of DCs in thyroid fine-needle aspirations (FNAs) have not been previously described. METHODS: The authors quantitatively assessed for the presence of DCs that were positive for cluster of differentiation 1a (CD1a) (a 43-49 kD protein expressed on DCs and cortical thymocytes) in cytologic samples of histologically confirmed PTC (n = 31) and in a control group of benign thyroid nodules (BTNs) (n = 29) using immunocytochemical staining with antibodies against CD1a. A subset of the corresponding PTCs (n = 11) and BTNs (n = 10) from surgical resection specimens also were assessed immunohistochemically for both CD1a and Langerin (a type II transmembrane cell surface receptor produced by Langerhans cells). RESULTS: CD1a-positive DCs were identified in 97% PTCs (n = 30 of 31 PTCs) in thyroid FNA specimens. DCs were largely present in 2 distinct patterns: either as isolated DCs in the background (n = 29 of 31) and/or associated with tumor cells (n = 30 of 31). Tumor-associated DCs (mean ± standard deviation: 6.44 ± 6.13 DCs per tumor cluster) exhibited multiple dendritic cytoplasmic processes extending over and between malignant cells within groups. The 3 PTC cases with the least DCs corresponded to the follicular variant at excision. In contrast, only 31% of BTNs (n = 9 of 29 BTNs; P = .0048) contained CD1a-positive DCs. When DCs were present in BTN, they were isolated primarily in the background (27%; n = 8 of 29), although 17% of BTNs (n = 5 of 29) contained rare DCs among thyrocytes, revealing both patterns in 4 cases. Both thyrocyte-associated DCs and background DCs were more numerous in PTC FNAs than in BTN FNAs, but only the thyrocyte-associated group of DCs was statistically significant (P < .0001 and P = .1173, respectively). Similar findings were reported in histologic samples in which all PTCs examined (n = 11 of 11) contained both CD1a-positive and Langerin-positive DCs; only 20% of BTNs (n = 2 of 10) contained rare DCs. CONCLUSIONS: CD1a-positive DCs were present in FNA specimens of PTC, typically in close association with tumor cells, whereas they were rare in BTNs. The increased presence of CD1a-positive DCs in PTC may be a useful diagnostic adjuvant. Cancer (Cancer Cytopathol) 2012. © 2012 American Cancer Society.Cancer Cytopathology 10/2012; · 3.33 Impact Factor
