Walter Georg Guder

Publications (162) View all

• Article: Tau protein in cerebrospinal fluid is significantly increased at the earliest clinical stage of Alzheimer disease.

  A Kurz, M Riemenschneider, K Buch, F Willoch, P Bartenstein, U Müller, W Guder
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  ABSTRACT: The concentration of tau protein in cerebrospinal fluid (CSF) was determined in 40 patients with clinically diagnosed probable Alzheimer disease (AD) and in 36 cognitively healthy controls. A significant increase of CSF tau was found in the AD patients, even in 19 subjects with very mild dementia as defined by a Mini-Mental State Examination score of 25 and above. Using a cutoff value of 260 pg/mL the sensitivity of elevated tau was 0.89, the specificity was 0.97, and the proportion of correctly allocated cases was 95%. In the AD groups there were no significant associations between CSF tau level and age, age at onset, duration of illness, apolipoprotein E genotype, severity of cognitive impairment, or deficit in regional cerebral blood flow as measured using 99Tm-ethyl cystein dimer single photon emission computed tomography. The findings demonstrate that CSF tau is significantly increased at the earliest clinical stage of AD and shows only minimal overlap with age-matched cognitively healthy controls. This finding suggests that CSF tau could be a biological marker of AD even before dementia has developed.
  Alzheimer Disease and Associated Disorders 01/1999; 12(4):372-7. · 2.81 Impact Factor
• Article: [Clinical chemistry in laboratory medicine in Europe. The past, present, and future].

  W Guder, J Buttner
  Klinicheskaia laboratornaia diagnostika 11/1998;
• Article: Is glucose a reliable index of carbohydrate metabolism? Report on the joint workshop conference "Glucose" of the German Society for Clinical Chemistry and the German Diabetes Society held on May 15-16, 1981 in Stuttgart, Germany.

  W Guder, J D Kruse-Jarres
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  ABSTRACT: The determination of glucose concentration is the most frequently used clinical laboratory test. It was the current vehemence in discussions about the judgement criteria for the diagnosis and monitoring of diabetes that motivated this discussion of pathobiochemical and analytical aspects in a circle of 38 experts. The composition of the working group made it possible to compare the needs of clinical diabetologists and diabetics with the analytical possibilities. Pathobiochemistry, sampling problems, diabetic self control, analytical methods and their standardisation, glucose monitoring, glucose sensors and glycosylated proteins were the topics of this glucose workshop.
  Journal of clinical chemistry and clinical biochemistry. Zeitschrift für klinische Chemie und klinische Biochemie 04/1982; 20(3):135-40.
• Article: Influence of hypophysectomy, thyroid hormone and insulin on the activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in rat liver.

  J Huber, W Guder, O A Müller, S Latzin, H Ganser, B Hamprecht
  Hoppe-Seyler's Zeitschrift für physiologische Chemie 07/1974; 355(6):669-74.
• Article: Influence of hypophysectomy and thyroid hormone on the activity of 3-hydroxy-3-methylglutaryl-coenzyme A-reductase in rat liver.

  J Huber, W Guder, O A Müller, S Latzin, H Ganser, B Hamprecht
  Zeitschrift für klinische Chemie und klinische Biochemie 06/1974; 12(5):269.