Viviana Nociti

Publications (49) View all

• Source

  Available from: Giacomo Della Marca

  Article: Erratum to: Both trigeminal autonomic cephalalgia and trigeminal neuralgia in a child.

  Valeria Rossi, Viviana Nociti, Concetta Palermo, Giacomo Della Marca, Paolo Mariotti
  Neurological Sciences 05/2013; · 1.32 Impact Factor
• Article: Chronic migraine-like headache caused by a demyelinating lesion in the brain stem.

  Paolo Mariotti, Viviana Nociti, Maria C Stefanini, Alessandro Cianfoni, Stefania Veltri, Gloria Ferrantini, Anna P Batocchi
  Pain Medicine 03/2012; 13(4):610-2. · 2.35 Impact Factor
• Article: Circulating CD8+CD56-perforin+ T cells are increased in multiple sclerosis patients.

  Frisullo Giovanni, Plantone Domenico, Marti Alessandro, Iorio Raffaele, Nociti Viviana, Patanella Agata Katia, Batocchi Anna Paola
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  ABSTRACT: Relapsing-remitting multiple sclerosis (RRMS), secondary progressive (SP)MS and primary progressive (PP)MS patients showed higher percentages of circulating CD8+CD56-perforin+ T cells than controls whereas only relapsing RRMS and PPMS patients showed higher perforin expression in CD8+CD56- T cells than controls. MS patients with EDSS ≥3 showed higher percentage of CD8+CD56-perforin+ T cells than patients with EDSS <3 and controls whereas patients with EDSS <3 showed higher percentage of this T cell subpopulation than controls. Our data show that MS is characterized by a dysregulation of CD8+CD56-perforin+ T cells that may play a role in the development of disability.
  Journal of neuroimmunology 12/2011; 240-241:137-41. · 2.84 Impact Factor
• Source

  Available from: Viviana Nociti

  Article: CD8(+)Foxp3(+) T cells in peripheral blood of relapsing-remitting multiple sclerosis patients.

  Giovanni Frisullo, Viviana Nociti, Raffaele Iorio, Domenico Plantone, A Katia Patanella, Pietro A Tonali, Anna Paola Batocchi
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  ABSTRACT: A defect of CD4(+) regulatory T cells (Treg) seems to be involved in the pathogenesis of multiple sclerosis (MS). Besides Treg, CD8(+) T cells also can suppress the immune response. Forkhead box p3 (Foxp3) is known to program the acquisition of suppressive capacities in CD4(+) T cells and recent studies showed that in vitro antigen activation leads to Foxp3 expression in CD8(+) T cells, gaining of suppressive activity. By flow cytometry we found a lower percentage of circulating CD8(+)Foxp3(+) T cells in relapsing than in remitting patients with MS and in controls. No significant differences were observed in CD8(+)Foxp3(+) T cell percentage between healthy subjects and patients in remission. Our data suggest that peripheral CD8(+)Foxp3(+) T cells may play a role in the maintenance of tolerance in MS.
  Human immunology 02/2010; 71(5):437-41. · 2.55 Impact Factor
• Article: Type 1 immune response in progressive multiple sclerosis.

  Giovanni Frisullo, Domenico Plantone, Alessandro Marti, Raffaele Iorio, Valentina Damato, Viviana Nociti, Agata Katia Patanella, Assunta Bianco, Anna Paola Batocchi
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  ABSTRACT: The aim of the study was to evaluate the type-1 immune response by analyzing T-bet expression in circulating T and B cells in Primary Progressive (PP) and Secondary Progressive (SP) Multiple Sclerosis (MS) patients. We found higher percentages of circulating CD4+T-bet+ and CD8+T-bet+ T cells in SPMS and PPMS than in remitting-relapsing MS patients and controls. Moreover, in SPMS, we observed a positive correlation between the percentages of circulating CD4+T-bet+ or CD8+T-bet+ T cells and disease severity. The increased percentages of Th1 and Tc1 cells suggest that MS progressive forms, unlike RRMS, are characterized by a permanent peripheral type-1 immune activation.
  Journal of neuroimmunology 05/2012; 249(1-2):112-6. · 2.84 Impact Factor