Vidya Sabale

Publications (6) View all

• Article: Formulation and in vitro evaluation of the topical antiageing preparation of the fruit of Benincasa hispida.

  Vidya Sabale, Harish Kunjwani, Prafulla Sabale
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  ABSTRACT: Ageing is the phase of gradual decline of body efficiency and metabolic activities after reaching a maturity stage. Free radicals cause oxidative alterations in collagen, elastin material and changes in membrane characteristics and induce polymerization reactions. Use of topical antioxidants can overcome some of these effects and retard actinic ageing. Herbal products are popular due to their minimum risk of side-effects with maximum efficacy. The present study was undertaken to evaluate the antiageing potential of Benincasa hispida fruit extract as not many scientific studies have been carried out to explore its utility as skin renewal enhancer and as an antioxidant. After removing the outer layer and the seeds, the fruit pulp was dried. The dried fruit pulp was extracted successively with petroleum ether, chloroform, ethyl acetate and methanol by Soxhlation for 2 days. Methanol was recovered under vacuum and a dry extract was obtained (yield 4.2% w/w), which was stored in a desiccator. Suitable topical cream base for effective carriage of fruit extract was developed and its in vitro evaluation for skin renewal activity was tested by application to the stratum corneum of human cadaver skin and by dansyl chloride fluorescence method. The results show that the cream prepared from Benincasa fruit extract may prove as an antiageing preparation and can be used for retarding the symptoms of ageing.
  Journal of Ayurveda and integrative medicine 07/2011; 2(3):124-8.
• Article: Comparative evaluation of rice bran wax as an ointment base with standard base.

  Vidya Sabale, P M Sabale, C L Lakhotiya
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  ABSTRACT: Waxes have been used in many cosmetic preparations and pharmaceuticals as formulation aids. Rice bran wax is a byproduct of rice bran oil industry. Present investigation has been aimed to explore the possible utility of rice bran wax as ointment base compared to standard base. The rice bran wax obtained, purified and its physicochemical characteristics were determined. Ointment base acts as a carrier for medicaments. The ointment base composition determines not only the extent of penetration but also controls the transfer of medicaments from the base to the body tissues. Rice bran wax base was compared with standard base for appearance, spreadability, water number, wash ability and diffusibility. The results show that rice bran wax acts as an ointment base as far as its pharmaceutical properties are concerned and it could effectively replace comparatively costlier available ointment bases.
  Indian Journal of Pharmaceutical Sciences 01/2009; 71(1):77-9. · 0.63 Impact Factor
• Article: Comparative evaluation of rice bran wax as an ointment base with standard base

  Vidya Sabale, P Sabale, C Lakhotiya
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  ABSTRACT: Waxes have been used in many cosmetic preparations and pharmaceuticals as formulation aids. Rice bran wax is a byproduct of rice bran oil industry. Present investigation has been aimed to explore the possible utility of rice bran wax as ointment base compared to standard base. The rice bran wax obtained, purified and its physicochemical characteristics were determined. Ointment base acts as a carrier for medicaments. The ointment base composition determines not only the extent of penetration but also controls the transfer of medicaments from the base to the body tissues. Rice bran wax base was compared with standard base for appearance, spreadability, water number, wash ability and diffusibility. The results show that rice bran wax acts as an ointment base as far as its pharmaceutical properties are concerned and it could effectively replace comparatively costlier available ointment bases.
  Indian Journal of Pharmaceutical Sciences. 01/2009;
• Article: In vitro studies on rice bran wax as skin moisturizer

  Vidya Sabale, P Sabale, C Lakhotiya
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  ABSTRACT: Waxes have been used in many cosmetic preparations and pharmaceuticals as formulation aids. Rice bran wax is a byproduct of rice bran oil industry. Present study aims to investigate possible use of rice bran wax as occlusive moisturizer. The rice bran wax obtained was purified and its physicochemical characteristics were determined. In vitro studies were carried out to determine trans epidermal water loss through stratum corneum and water holding capacity of stratum corneum of human cadaver skin treated with pure rice bran wax and formulation of rice bran wax. The results show that rice bran wax can be used as a promising occlusive moisturizer.
  Indian Journal of Pharmaceutical Sciences. 01/2007;
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  Article: Taxus - the panacea for cancer treatment.

  Lavhle Manish, Bhalekar Mangesh, Vidya Sabale
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  ABSTRACT: Cancer has been major challenge for healthcare sector for a long time. The use of chemotherapy and radiation therapy has its obvious side effects. The scientists have been looking to natural remedies for the treatment of cancer. There have been significant discoveries in this direction such as Vinblastine the plant alkaloids. Recent discovery of Taxol a diterpenoid obtained form Taxus species has opened new vistas in the treatment of cancer and can be considered a major break through. This article is an attempt to overview the various aspects such as biological & geographical sources, active principles, mechanism of action, extraction, isolation, estimation and traditional uses of Taxol.
  Ancient science of life. 01/2005; 24(3):152-9.