Vagner Rodrigues Santos

Publications (21) View all

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  Available from: Vagner Rodrigues Santos

  Article: Influence of natural coffee compounds, coffee extracts and increased levels of caffeine on the inhibition of Streptococcus mutans

  A A P Almeida, C C Naghetini, V R Santos, A G Antonio, A Farah, M B A Glória
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  ABSTRACT: The inhibition of Streptococcus mutans by Coffea arabica extracts incorporated or not with natural coffee compounds was investigated by the disk diffusion method. Additionally, the turbidimetric test was used to verify the influence of caffeine concentration on the inhibition of S. mutans. Extracts of different samples of Arabica coffee showed antibacterial activity against S. mutans. The inhibitory effect was not affected by the brewing method (filtered or espresso) or by the different Arabica coffee samples. Plain caffeine, trigonelline, caffeic acid, protocatechuic acid and chlorogenic acid at 2.0 mg/mL provided similar antimicrobial effect against S. mutans. However, there was an increase in the antibacterial activity when these compounds were added to the coffee extract, except for chlorogenic acid which did not affect the inhibitory effect. Caffeine at concentrations found in Arabica beverages inhibited S. mutans temporarily, whereas higher caffeine concentrations provided a stronger and longer lasting inhibition.
  Food Research International 08/2012; 49(49):459-461. · 3.15 Impact Factor
• Article: In vitro antimicrobial activity of Brazilian medicinal plant extracts against pathogenic microorganisms of interest to dentistry.

  Elizete Maria Pereira, Rafael Tomaz Gomes, Natália Ribeiro Freire, Evandro Guimarães Aguiar, Maria das Graças Lins Brandão, Vagner Rodrigues Santos
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  ABSTRACT: This study evaluated the susceptibility of oral pathogenic microorganisms Candida albicans, Streptococcus mutans, Staphylococcus aureus, and Aggregatibacter actinomycetemcomitans to Brazilian medicinal plant extracts of Schinus terebinthifolius (aroeira), Croton campestris (velame), Lafoensia pacari (pacari), Centaurium erythraea (centáurea), Stryphnodendron adstringens (barbatimão), and Anacardium humile (cajuzinho-docerrado), as compared to standardized antimicrobial agents (nystatin, chloramphenicol and tetracycline hydrochloride). Ethanol, hexane and butane fractions from stem barks, rinds, leaves, and/or roots were extracted and tested. Antimicrobial diffusion agar test and MIC were performed according to CLSI. After 24 h of incubation at 37 °C, the diameter of inhibition zones and spectrophotometer readings were measured and compared. The results were reported as means ± standard deviation (M ± SD). With the exception of five extracts that showed no antimicrobial activity, all the extracts tested showed antimicrobial activity, in different levels. This study suggests that extracts from the plants tested could be an alternative therapeutic option for infectious conditions of the oral cavity, such as denture stomatitis, dental caries, and periodontitis.
  Planta Medica 03/2011; 77(4):401-4. · 2.15 Impact Factor
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  Available from: Efigênia Ferreira E Ferreira

  Article: Clinical Evidence of the Efficacy of a Mouthwash Containing Propolis for the Control of Plaque and Gingivitis: A Phase II Study.

  Elizete Maria Rita Pereira, João Luís Duval Cândido da Silva, Fernando Freitas Silva, Mariana Passos De Luca, Efigênia Ferreira E Ferreira, Telma Campos Medeiros Lorentz, Vagner Rodrigues Santos
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  ABSTRACT: The aim of this study was to evidence the clinical efficacy of an alcohol-free mouthwash containing 5.0% (W/V) Brazilian green propolis (MGP 5%) for the control of plaque and gingivitis. Twenty five subjects, men and women aging between 18 and 60 years old (35 ± 9), were included in a clinical trials phase II study who had a minimum of 20 sound natural teeth, a mean plaque index of at least 1.5 (PI), and a mean gingival index of at least 1.0 (GI). They were instructed to rinse with 10 mL of mouthwash test for 1 minute, immediately after brushing in the morning and at night. After 45 and 90 days using mouthwash, the results showed a significant reduction in plaque and in gingival index when compared to samples obtained in baseline. These reductions were at 24% and 40%, respectively (P < .5). There were no important side effects in soft and hard tissues of the mouth. In this study, the MGP 5% showed evidence of its efficacy in reducing PI and GI. However, it is necessary to perform a clinical trial, double-blind, randomized to validate such effectiveness.
  Evidence-based Complementary and Alternative Medicine 01/2011; 2011:750249. · 4.77 Impact Factor
• Article: Efficacy of Brazilian propolis gel for the management of denture stomatitis: a pilot study.

  Vagner R Santos, Rafael T Gomes, Ricardo A de Mesquita, Mariela D G de Moura, Esdras C França, Evandro G de Aguiar, Marcelo D Naves, José A S Abreu, Sheila R L Abreu
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  ABSTRACT: Denture stomatitis presents as a chronic disease in denture-bearing patients, especially under maxillary prosthesis. Despite the existence of a great number of antifungal agents, treatment failure is observed frequently. Propolis, a natural bee product, possesses well-documented antifungal and anti-inflammatory activities. The purpose of this study was to evaluate the clinical efficacy of a new Brazilian propolis gel formulation in patients diagnosed with denture stomatitis. Thirty complete-denture wearers with denture stomatitis were enrolled in this pilot study. At baseline, clinical evaluation was performed by a single clinician and instructions for denture hygiene were provided. Fifteen patients received Daktarin (Miconazole gel) and 15 received Brazilian propolis gel. All patients were recommended to apply the product four times a day during one week. Clinical evaluation was repeated by the same clinician after treatment. All patients treated with Brazilian propolis gel and Daktarin had complete clinical remission of palatal edema and erythema. This new Brazilian propolis gel formulation had efficacy comparable to Daktarin and could be an alternative topical choice for the treatment of denture stomatitis.
  Phytotherapy Research 08/2008; 22(11):1544-7. · 2.09 Impact Factor
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  Available from: Vagner Rodrigues Santos

  Article: Esterilização em Ortodontia: eficácia do esterilizador com esferas de vidro A R T I G O I N É D I T O

  Sônia Rodrigues Dutra, Vagner Rodrigues Santos, Leonardo Foresti, Soares De Menezes, Alexandre Fortes Drummond, Ênio Lacerda Vilaça, Paulo Henrique, Amêndola Couto, Introdução E Revisão, De Literatura
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  ABSTRACT: Objetivo: avaliar a efetividade do esterilizador com esferas de vidro Steri ® 350, quanto ao controle de infecção das partes ativas dos alicates ortodônticos. Metodologia: foram utilizados nove alicates ortodônticos, previamente esterilizados em autoclave à temperatura de 121ºC, durante 20 minutos. Posteriormente, as partes ativas dos alicates foram contaminadas com Bacillus stearothermophilus. Logo após, as pontas dos alicates foram colocadas no Steri ® 350, durante os períodos de 3, 5, 10, 15, 20, 30 e 40 segundos, em temperatura de 255ºC, para avaliar a eficácia da esterilização. Resultados e Conclusões: o esterilizador com esferas de vidro mostrou-se eficaz no controle do crescimento de Bacillus stearothermophilus nas partes ativas dos alicates ortodônticos, a partir de 10 segundos de exposição à temperatura de 255ºC. Os profissionais da área ortodôntica, assim como aqueles de todas as especialidades odon-tológicas, devem instalar em seus consultórios barreiras para o controle de infecção cruzada. Es-tas barreiras incluem o uso de aparatologia pelo profissional e auxiliar (óculos, máscara, avental e luvas), desinfecção ou cobrimento de superfícies tocadas pelo paciente ou pelo profissional, "esteri-lização a frio" ou desinfecção de materiais termos-sensíveis e esterilização por calor de instrumentos não-termossensíveis 6 . Esterilização é a eliminação de todas as formas
  Revista Dental Press de Ortodontia e Ortopedia Facial 01/2008; 13(4):60-66.