Tirath Das Dogra

Publications (222) View all

• Article: Assessment of endocrine abnormalities in severe traumatic brain injury: a prospective study.

  Asheesh Tandon, Ashish Suri, Manish Kumar Kasliwal, Ashok Kumar Mahapatra, Veer Singh Mehta, Ajay Garg, Chitra Sarkar, T D Dogra, R M Pandey
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  ABSTRACT: The frequency and pattern of endocrine abnormalities among patients with traumatic brain injury have been the subject matter of very few studies. This study was intended to assess the pattern of endocrine dysfunction following severe head injury. Severe head injury patients admitted to the Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, from January to December in 1 year formed the study group. Apart from clinical assessment, NCCT of the head was performed on all patients on admission. A complete anterior pituitary hormone analysis was performed within 24 h of injury and was repeated at 2 weeks, 3 months and 6 months amongst patients who survived. A total of 99 patients were included in the study. Forty of our patients succumbed in the hospital. Rest of the patients were followed up for 6 months. Elevations of cortisol followed by prolactin were the most common hormonal derangements at admission. Midline shift on CT scans was inversely related to cortisol elevation and directly related to GH elevation. Infarct on CT scans was inversely related to cortisol and LH elevation. A significant alteration was found in the decreasing trend of the mean T4 values and normalisation or a decreasing trend from initially elevated mean cortisol and GH levels during follow-up (p < 0.05). This study reveals that abnormalities in hormonal profiles appear to be relatively common in severe traumatic brain injury and fluctuate significantly over at least 6 months; there is a correlation with age and radiological findings. Performance of hormonal analysis evaluation should be considered in patients with severe brain injury so that appropriate hormonal replacement can be done to optimise the clinical outcome.
  Acta Neurochirurgica 07/2009; 151(11):1411-7. · 1.52 Impact Factor
• Article: Rapid method for the determination of some organophosphorus insecticides in a small amount of serum in emergency and occupational toxicology cases

  Bhoopendra Singh, T Dogra
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  ABSTRACT: A simple and rapid method is described for the estimation of some organophosphorus insecticides in the serum of occupationally exposed persons. The compounds are extracted with a mixture of acetone and diethyl ether (1:1 v/v) in acidic medium and the extraction residue is analyzed by gas chromatography with nitrogen phosphorus detection method. Linearity was acceptable over concentrations from 0.25 to 4.0 µg/mL. The method percentile recovery for the six different organophosphorus insecticides was 86.3% for phorate, 78.3% for dimethoate, 82.3% for malathion, 79.4% for chlorpyrifos, 80.2% for diazinon, and 68.5% for ethion at the µg/mL level. Serum samples of nine workers who had been occupationally exposed to malathion in an insecticide manufacturing factory, were analyzed and malathion was found at low levels in all the samples.
  Indian Journal of Occupational and Environmental Medicine. 01/2009;
• Article: Dr. T D Dogra’s Expert Evidence in trial of assassination of Late Mrs Indira Gandhi, Prime Minister of India (Witness No. PW 5)

  Raina Anupuma,  Lalwani Sanjeev,  Dogra TD
  Indian Internet Journal of Forensic Medicine and Toxicology. 01/2009; 7.
• Article: Relatives' attitudes towards medico-legal investigation and forensic autopsy: a study from South Delhi.

  C Behera, R Rautji, T D Dogra
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  ABSTRACT: Relatives of deceased persons on whose bodies a medico-legal autopsy had been performed at the All India Institute of Medical Sciences, New Delhi, India were personally asked to complete a questionnaire. The aim of study was to determine surviving family members' attitudes towards medico-legal investigation and forensic autopsy. The majority of the relatives showed a positive attitude towards forensic autopsy but were not aware of the detailed procedure of the autopsy. They wanted sufficient information to be provided before the autopsy. They showed a great interest in autopsy results i.e. the cause of death. It was concluded that sufficient relevant explanations given before the autopsy improves the relatives' acceptance and helps alleviate the suffering of the bereaved. The experience and opinions of relatives may help an autopsy surgeon in more effective management of medico-legal cases.
  Medicine, science, and the law 05/2008; 48(2):159-62. · 0.45 Impact Factor
• Article: Decapitation with egg shelling of the skull in a road traffic accident: a case report.

  C Behera, Ravi Rautji, T D Dogra
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  ABSTRACT: A 40-year-old lady was found dead on a road early one morning. She had allegedly been run over by a speeding vehicle. The head of the deceased had been decapitated, with egg shelling of the skull from the scalp and face. The skull was lying a little distance away from the rest of the body. Although decapitation is not an unknown entity in a road traffic accident, subsequent egg shelling of the skull, leaving behind scalp and face tissue, has not been reported in a road traffic accident in the forensic literature.
  Medicine, science, and the law 02/2008; 48(1):87-8. · 0.45 Impact Factor