Thomas August

MS Pharmaceutical Chemistry
United Chemical Technology · Reseach and Development

Topics (17) View all

Skills (8)

Research experience

  • Jun 2006–
    Nov 2010
    Teaching: Manager Investigational Drugs Area
    The Childrens Hospital of Philadelpha · Pharmacy · Investigational Pharmacy
    USA · Philadelphia , Pa
    Ran the Investigational pharmacy, administered to over 200 studies provided both dispensing, IRB and Adverse events roles.
  • Jun 1998–
    Jun 2001
    Research: Bioanalytical Development of Drug metabolism candidates
    Sterling Winthrop Pharmaceuticals · Drug Metabolism · Bioanalytical Chemistry
    USA · Colledgeville, Pa
    Manager of a research team developing drug candidates for approval to the US and Universal drug markets.
  • May 1991–
    Jun 1998
    Teaching: Technical Manager the Hospital Univ of Pa Toxicology Lab
    Hospital of the University of Pennsylvania · Toxicology Laboratory
    USA · Philadelphia
    Ran Hospital lab 24hr/d 7 days per week that ran Toxicology screenings and developed methods for drugs of abuse.

Education

  • Sep 1970–
    May 1979
    University of the Sciences in Philadelphia
    Pharmacy / Pharmaceutical Chemistry · BS-MS
    USA · Philadelphia

Other

  • Languages
    English
  • Scientific Memberships
    AAPS
  • Other Interests
    String Band Mummer, Sailing, Reading, Writing books

Questions and Answers (8) View all

  • Answer added in Pharmacology
    70 Are medical errors a sign of incompetence among physicians or can it be reduced through change in medical culture or attitude of the medical professionals?
    By Geir Bjorklund · Umeå University
    Thomas August · United Chemical Technology
    I have written much on this subject however I now propose a way to resolve the issues in a cheap and very efficient manner for both the doctor, pharma... [more]
  • Answer added in Pharmacology
    70 Are medical errors a sign of incompetence among physicians or can it be reduced through change in medical culture or attitude of the medical professionals?
    By Geir Bjorklund · Umeå University
    Thomas August · United Chemical Technology
    Hello to all- the discussion has been enlightening the many views on this subject however I must say that this subject has many facets to it. If you g... [more]
  • Answer added in Pharmacology
    70 Are medical errors a sign of incompetence among physicians or can it be reduced through change in medical culture or attitude of the medical professionals?
    By Geir Bjorklund · Umeå University
    Thomas August · United Chemical Technology
    The problem with the errors is that they are too many and also we are talking of human lives that are affected. Why do we not have a system in place t... [more]
  • Answer added in Pharmacology
    70 Are medical errors a sign of incompetence among physicians or can it be reduced through change in medical culture or attitude of the medical professionals?
    By Geir Bjorklund · Umeå University
    Thomas August · United Chemical Technology
    The problem in the making of mistakes and errors also lies in the attitudes of the doctors versus the nurses versus the pharmacist. Many times the pha... [more]
  • Answer added in Pharmacology
    70 Are medical errors a sign of incompetence among physicians or can it be reduced through change in medical culture or attitude of the medical professionals?
    By Geir Bjorklund · Umeå University
    Thomas August · United Chemical Technology
    PHARMACISTS AND DOCTORS BY THEIR PROFESSION ARE HELD TO THE HIGHEST STANDARD OF PERFORMING THEIR DUTIES WITHOUT ERROR OR FACE SIGNIFICANT LEGAL SANCTI... [more]

Publications (4) View all

  • Article: Bioanalysis and disposition of α‐fluoromethylhistidine, a new histidine decarboxylase inhibitor
    [show abstract] [hide abstract]
    ABSTRACT: A sensitive, selective, and rapid high-performance liquid chromatographic procedure was developed for the determination of -fluoromethylhistidine (-FMH) in human biological samples. The plasma assay required isolation of the drug using a weak cation-exchange resin prior to HPLC analysis with UV detection. The urine assay employed postcolumn derivatization with o-phthalaldehyde (without a thiol) and fluorescence detection. The extent of metabolism of -FMH in humans was studied in four healthy volunteers using tritium-labeled material. No significant differences in the plasma and urine concentrations of radioactivity and unchanged drug were detected. In addition, the radiochromatograms of selected urine samples revealed a single peak with a retention time corresponding to the unchanged drug. The evidence presented suggests negligible biotransformation of -FMH in humans.
    Journal of Pharmaceutical Sciences 09/2006; 74(8):871 - 875. · 3.06 Impact Factor
  • Source
    Book: Forensic and Clinical Application of Solid Phase Extraction
    Telepchak, Michael, August Thomas F, Chaney =, Glynn
    [show abstract] [hide abstract]
    ABSTRACT: Solid Phase Extraction has become a powerful and extensively used technique in the clean up and concentration of samples for analysis. in a wide variety of analytical techniques, In Forensic and Clinical Applications of Solid phase extraction hands-on experts explain the principles of SPE and provide a host of readily reproducible protocols designed to allow the reader to master the skills necessary to utilize SPE and develop methods to drugs similar to the protocols. This is a cookbook of methods for forensic and clinical chemists alike.
    First edited by Karsch, Steve, 06/2004; Humana Press., ISBN: 0-89603-648-0
  • Article: Simultaneous high-performance liquid chromatographic analysis of carbidopa, levodopa and 3-O-methyldopa in plasma and carbidopa, levodopa and dopamine in urine using electrochemical detection.
    [show abstract] [hide abstract]
    ABSTRACT: Two assay procedures are described for the analysis of levodopa, carbidopa and 3-O-methyldopa in plasma and levodopa, carbidopa and dopamine in urine. The methods are suitable for quantifying the analytes following therapeutic administration of levodopa and carbidopa. Both were based on reversed-phase high-performance liquid chromatography (HPLC) with electrochemical detection and with methyldopa as the internal standard. Plasma samples were prepared by perchloric acid precipitation followed by the direct injection of the supernatant. Urine was prepared by alumina adsorption, and the analytes were desorbed with perchloric acid solution containing disodium EDTA and sodium metabisulfite prior to injection into the HPLC system. The methods have been utilized to evaluate the pharmacokinetics and bioavailability of oral dosage forms containing levodopa and carbidopa.
    Journal of Chromatography 01/1991; 534:87-100. · 4.53 Impact Factor
  • Article: Pharmacokinetics and bioavailability of Sinemet CR: a summary of human studies.
    [show abstract] [hide abstract]
    ABSTRACT: The pharmacokinetics of Sinemet CR, a controlled-release formulation containing carbidopa and levodopa, were investigated in healthy young and elderly volunteers and in patients with Parkinson's disease. Sinemet CR produced more sustained plasma levels of levodopa, carbidopa, and 3-O methyldopa than did conventional Sinemet. In elderly subjects, the corresponding steady-state plasma levels fluctuated in narrower ranges with Sinemet CR than those following the administration of Sinemet. Results indicate a levodopa bioavailability of 71% for Sinemet CR, in contrast to a bioavailability of 99% for Sinemet for these subjects. The carbidopa bioavailability of Sinemet CR was 58% relative to that of Sinemet. Systemic decarboxylase inhibition was comparable between the 2 regimens as indicated by the renal clearance of levodopa. The absorption of levodopa was slower and more protracted with Sinemet CR than with Sinemet. Food increased the levodopa bioavailability of Sinemet CR. This increase was attributed to an increased gastric retention time. No dose-dumping occurred with Sinemet CR in either the nonfasting or the fasting state. Levodopa bioavailability was lower in young volunteers than in elderly volunteers. This was attributed to an age-related decrease in gastric emptying and in 1st-pass metabolic decarboxylation in the gastrointestinal (GI) tract. In parkinsonian patients, as in healthy subjects, the Sinemet CR formulation produced more sustained levodopa plasma levels. These patients required a higher total daily dosage of Sinemet CR than of Sinemet for control of parkinsonian symptoms, but less frequent dosing was required during chronic therapy. Peak plasma levodopa levels increased proportionately with increasing Sinemet CR dosage. These observations were consistent with the pharmacokinetic characteristics of the formulation.
    Neurology 12/1989; 39(11 Suppl 2):25-38. · 8.31 Impact Factor

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