Research: University of UlsterUniversity of Ulster · School of Biomedical Sciences, Centre for Molecular BiosciencesDerry · United Kingdom
Research: Beaumont HospitalBeaumont HospitalDublin · Ireland (Republic of Ireland)
Research: University of DundeeUniversity of Dundee · Division of Molecular MedicineDundee · United Kingdom
Research: Queen's University BelfastQueen's University Belfast · School of Mathematics and PhysicsBelfast · United Kingdom
Research: Ocular ResearchUniversity of Ulster · Biomedical SciencesUnited Kingdom · BelfastResearch involves the optimisation of gene silencing for use in treatment or preventation of corneal dystrophy through a number of different methods of targeting the causative mutation combined with novel delivery methods in preclinical human models.
NILTGAnimal Scientic Procedures CertificateBelfast
University of UlsterE Tutor CertificateUnited Kingdom · Belfast
University of UlsterPGCHEPUnited Kingdom · Belfast
MEEI / Harvard Medical School, BostonResearch FellowshipBoston, USA
Queen's University BelfastEducation · Teacher / Tutor Certificate in Education (high commedation)United Kingdom · Belfast
Queen's University BelfastImmunology & Virology · PhDUnited Kingdom · Belfast
Queen's University BelfastMicrobiology · BSc (First Class Honours)United Kingdom · Belfast
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ABSTRACT: In Northern Ireland 1 in every 454 women of 13 years and over during 2008/09 reported to police that they had suffered a sexual assault. This study considered the possibility that women may be more likely to be victims of sexual assault during the fertile phase of their reproductive cycle. Evolutionary psychology suggests that women would have suffered more negative consequences if sexually assaulted when fertile and that specific psychological mechanisms may have evolved in women to combat male coercion. Female behaviours towards men vary across the reproductive cycle and men's behaviour towards women may vary also as a result of changes in female hormones. Hormones play a major role in producing the characteristic cyclical changes throughout a woman's reproductive life. This study is the first study of female hormone influences on sexual assaults. The data for the study was collated retrospectively from the records of 105 females with regular, spontaneous menstrual cycles. These females alleged recent sexual assault and were examined in Belfast during the period 2002-2009. The study concluded that young girls in the middle of their cycle, i.e. the fertile phase, were most at risk of sexual assault. It is possible that both sexes are sensitive to signs, albeit subtle behavioural signs, indicating high risk of conception.Journal of forensic and legal medicine 10/2011; 18(7):313-6.
Article: The use of infrared aided photography in identification of sites of bruises after evidence of the bruise is absent to the naked eye.[show abstract] [hide abstract]
ABSTRACT: The purpose of the study was to determine whether Infrared imaging could play a role in the detection of previous blunt force injury after resolution of skin changes were no longer visible to the human eye. Investigations were performed using an adapted digital camera and the same standard Nikon camera body to photograph the bruises of ten volunteer adult subjects. The same lens was fitted to each camera body and each bruise was photographed until it was no longer possible to identify it with the naked eye. The results of photographing subjects over 6 months demonstrated that the median time the bruises persisted in both groups was approximately between 18 and 19 days. There was no statistically significant difference between groups of bruises photographed with both the infrared digital camera that had been adapted to capture only infrared light, and with the standard camera which had the same lens fitted to it. The two groups of photographs of bruises imaged at the same time with the two cameras were not significantly different with regard to what skin changes could be detected. The use of the near infrared spectrum, with wavelengths that are longer than the human eye can detect, did not reveal significant evidence of bruising after it had faded from view to both the human eye and to a standard camera.Journal of forensic and legal medicine 08/2010; 17(6):293-7.
International Journal of Clinical Practice 02/2012; 66(2):226. · 2.41 Impact Factor
Article: Effect of tear hyperosmolarity and signs of clinical ocular surface pathology upon conjunctival goblet cell function in the human ocular surface.Jonathan E Moore, Gilbert T Vasey, Darlene A Dartt, Victoria E McGilligan, Sarah D Atkinson, Claire Grills, Philip J Lamey, Antonio Leccisotti, David G Frazer, Tara C B Moore[show abstract] [hide abstract]
ABSTRACT: To investigate the effect of tear hyperosmolarity and signs of clinical ocular surface pathology on conjunctival goblet cell population. 111 participants were assessed using tear osmolarity (TO) measurements and a comprehensive selection of clinical ophthalmic tests. The resultant clinical database was assessed for evidence of patterns of composite increasing pathology. The total, filled, and empty goblet cell numbers were measured: total number of goblet cells as per cytokeratin 7 (CK7) immunofluorescence and number of filled goblet cells as per periodic acid Schiff's reagent (PAS) or lectin helix pomatia agglutinin (HPA). Goblet cell profile was correlated with composite clinical pathologic grades. No significant correlation was found between TO and goblet cell number or function (as indicated by number of filled or unfilled goblet cells). Distinct composite clinical pathologic groups 0-IV with increasing pathology were created based on the frequency of positive pathologic signs, which adhered to the Dry Eye Workshop purported mechanism. Only in group IV was there significantly increased mean tear osmolarity of 344 mOsm/L (P < 0.000) along with significantly decreased empty goblet cell number (CK7+ and HPA-) compared to filled (CK7+ and HPA+, P = 0.000). When the number of filled goblet cells (PAS+) was analyzed there was significant increase in tear osmolarity for the two most severe grades; 3 and 4. The goblet cell population does not appear to be affected by isolated tear hyperosmolarity. Hyperosmolarity when combined with other ocular surface pathology or inflammation alters the goblet cell population.Investigative ophthalmology & visual science 04/2011; 52(9):6174-80. · 3.43 Impact Factor
Article: Early flap displacement after LASIK.[show abstract] [hide abstract]
ABSTRACT: To evaluate the risks of flap displacement after LASIK. Retrospective case series. We included 41 845 consecutive adults who underwent LASIK surgery at Optical Express in the United Kingdom, including 81 238 eyes, of which 14 555 were hyperopic and 66 681 myopic or mixed astigmatic. We treated 57 241 eyes with the IntraLase FS-60 femtosecond laser and 23 997 with the Moria S.A. ONE Use-Plus automated microkeratome. We calculated the incidence of all flap displacements in the study population during an observational time period of ≥12 months after surgery. Independent variables were entered into logistic regression models to identify risk factors. Postoperative outcomes were assessed. The incidence and odds ratios (OR) of flap displacement in the study population and in categories of refractive error and flap surgery technique. The incidence of flap displacements was 10 in 81 238 LASIK procedures (0.012%), including 8 hyperopic eyes (0.055%) and 2 myopic eyes (0.003%). All flap displacements occurred within 48 hours of surgery and none were preceded by ocular trauma. They were classified as "early flap displacements" (EFD). The incidence of EFD after microkeratome surgery was 0.033% (n = 8), and after femtosecond laser it was 0.003% (n = 2). In hyperopic eyes having microkeratome surgery, the incidence was 0.179% (n = 7). In a logistic regression model, the strongest predictor of EFD after LASIK was hyperopia, recording an OR of 19.29 (P<0.001). The OR of developing an EFD after microkeratomy was 10.53 times higher than after femtosecond laser (P<0.005). In hyperopes, the OR of an EFD was 18.87 times higher after microkeratomy than after femtosecond treatment. Four of 10 displaced flaps needed secondary surgery, and 1 eye lost 2 lines of best-corrected visual acuity. The incidence of flap displacements during a 12-month period after LASIK was extremely low (0.012%). Although the small number of displacements with the femtosecond laser limits conclusions, the risk of EFD was higher after microkeratome surgery than femtosecond laser.Ophthalmology 05/2011; 118(9):1760-5. · 5.45 Impact Factor
Tara works in the University of Ulster where she has developed online courses for eye related surgery and forensic and legal medicine professionals. Tara leads a small research team of post doctoral researchers, PhD students, MSc students and undergraduate students. For more detail on specific research activity see www.taramoore.org