Syed A Ali

Immunology, Biotechnology



Our primary research interest is to target HIV-1 P24 and Nef proteins by using cell penetrating mAbs. We have shown that mAbs chemically conjugated to kFGF-MTS can internalize into cells, target HIV p24, and inhibit HIV-1 replication in cells. Small format mAbs such as scFv have several advantages over full sized IgG. We have made antibody phage display libraries and isolated high affinity (1-30 NM) anti-p24 and anti-Nef scFvs. We are now evaluating them as anti-HIV intrabodies and transmAbs.

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