Susanna Lagorio

Publications (53) View all

• Article: Survival of European patients with central nervous system tumors.

  Milena Sant, Pamela Minicozzi, Susanna Lagorio, Tom Børge Johannesen, Rafael Marcos-Gragera, Silvia Francisci
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  ABSTRACT: We present estimates of population-based 5-year relative survival for adult Europeans diagnosed with central nervous system tumors, by morphology (14 categories based on cell lineage and malignancy grade), sex, age at diagnosis and region (UK and Ireland, Northern, Central, Eastern and Southern Europe) for the most recent period with available data (2000-2002). Sources were 39 EUROCARE cancer registries with continuous data from 1996 to 2002. Survival time trends (1988 to 2002) were estimated from 24 cancer registries with continuous data from 1988. Overall 5-year relative survival was 85.0% for benign, 19.9% for malignant tumors. Benign tumor survival ranged from 90.6% (Northern Europe) to 77.4% (UK and Ireland); for malignant tumors the range was 25.1% (Northern Europe) to 15.6% (UK and Ireland). Survival decreased with age at diagnosis and was slightly better for women (malignant tumors only). For glial tumors, survival varied from 83.5% (ependymoma and choroid plexus) to 2.7% (glioblastoma); and for non-glioma tumors from 96.5% (neurinoma) to 44.9% (primitive neuroectoderm tumor/medulloblastoma). Survival differences between regions narrowed after adjustment for morphology and age, and were mainly attributable to differences in morphology mix; however UK and Ireland and Eastern Europe patients still had 40% and 30% higher excess risk of death, respectively, than Northern Europe patients (reference). Survival for benign tumors increased from 69.3% (1988-1990) to 77.1% (2000-2002); but survival for malignant tumors did not improve indicating no useful advances in treatment over the 14-year study period, notwithstanding major improvement in the diagnosis and treatment of other solid cancers.
  International Journal of Cancer 07/2011; 131(1):173-85. · 5.44 Impact Factor
• Source

  Available from: Riitta Mäntylä

  Article: Location of gliomas in relation to mobile telephone use: a case-case and case-specular analysis.

  Suvi Larjavaara, Joachim Schüz, Anthony Swerdlow, Maria Feychting, Christoffer Johansen, Susanna Lagorio, Tore Tynes, Lars Klaeboe, Sven Reidar Tonjer, Maria Blettner, [......], Anders Ahlbom, Olof Flodmark, Anders Lilja, Stefano Martini, Emanuela Rastelli, Antonello Vidiri, Veikko Kähärä, Jani Raitanen, Sirpa Heinävaara, Anssi Auvinen
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  ABSTRACT: The energy absorbed from the radio-frequency fields of mobile telephones depends strongly on distance from the source. The authors' objective in this study was to evaluate whether gliomas occur preferentially in the areas of the brain having the highest radio-frequency exposure. The authors used 2 approaches: In a case-case analysis, tumor locations were compared with varying exposure levels; in a case-specular analysis, a hypothetical reference location was assigned for each glioma, and the distances from the actual and specular locations to the handset were compared. The study included 888 gliomas from 7 European countries (2000-2004), with tumor midpoints defined on a 3-dimensional grid based on radiologic images. The case-case analyses were carried out using unconditional logistic regression, whereas in the case-specular analysis, conditional logistic regression was used. In the case-case analyses, tumors were located closest to the source of exposure among never-regular and contralateral users, but not statistically significantly. In the case-specular analysis, the mean distances between exposure source and location were similar for cases and speculars. These results do not suggest that gliomas in mobile phone users are preferentially located in the parts of the brain with the highest radio-frequency fields from mobile phones.
  American journal of epidemiology 07/2011; 174(1):2-11. · 5.59 Impact Factor
• Article: Brain tumour risk in relation to mobile telephone use: results of the INTERPHONE international case-control study

  E. Cardis, I. Deltour, M. Vrijheid, E. Combalot, M. Moissonnier, H. Tardy, B. Armstrong, G. Giles, J. Brown, J. Siemiatycki, [......], K. G. Blaasaas, L. Klaeboe, M. Feychting, S. Loenn, A. Ahlbom, P. A. McKinney, S. J. Hepworth, K. R. Muir, A. J. Swerdlow, M. J. Schoemaker
  International Journal of Epidemiology 01/2010; 39(3):675. · 6.41 Impact Factor
• Article: Brain tumour risk in relation to mobile telephone use: results of the INTERPHONE international case-control study

  E. Cardis, I. Deltour, M. Vrijheid, E. Combalot, M. Moissonnier, H. Tardy, B. Armstrong, G. Giles, J. Brown, J. Siemiatycki, [......], K. G. Blaasaas, L. Klaeboe, M. Feychting, S. Loenn, A. Ahlbom, P. A. McKinney, S. J. Hepworth, K. R. Muir, A. J. Swerdlow, M. J. Schoemaker
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  ABSTRACT: Methods An interview-based case-control study with 2708 glioma and 2409 meningioma cases and matched controls was conducted in 13 countries using a common protocol. Results A reduced odds ratio (OR) related to ever having been a regular mobile phone user was seen for glioma [OR 0.81; 95% confidence interval (CI) 0.70-0.94] and meningioma (OR 0.79; 95% CI 0.68-0.91), possibly reflecting participation bias or other methodological limitations. No elevated OR was observed >= 10 years after first phone use (glioma: OR 0.98; 95% CI 0.76-1.26; meningioma: OR 0.83; 95% CI 0.61-1.14). ORs were < 1.0 for all deciles of lifetime number of phone calls and nine deciles of cumulative call time. In the 10th decile of recalled cumulative call time, >= 1640 h, the OR was 1.40 (95% CI 1.03-1.89) for glioma, and 1.15 (95% CI 0.81-1.62) for meningioma; but there are implausible values of reported use in this group. ORs for glioma tended to be greater in the temporal lobe than in other lobes of the brain, but the CIs around the lobe-specific estimates were wide. ORs for glioma tended to be greater in subjects who reported usual phone use on the same side of the head as their tumour than on the opposite side. Conclusions Overall, no increase in risk of glioma or meningioma was observed with use of mobile phones. There were suggestions of an increased risk of glioma at the highest exposure levels, but biases and error prevent a causal interpretation. The possible effects of long-term heavy use of mobile phones require further investigation.
  International Journal of Epidemiology 01/2010; 39(3):675-694. · 6.41 Impact Factor
• Article: Determinants of mobile phone output power in a multinational study: implications for exposure assessment.

  M Vrijheid, S Mann, P Vecchia, J Wiart, M Taki, L Ardoino, B K Armstrong, A Auvinen, D Bédard, G Berg-Beckhoff, [......], S Lagorio, S Lönn, M McBride, L Montestrucq, R C Parslow, S Sadetzki, J Schüz, T Tynes, A Woodward, E Cardis
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  ABSTRACT: The output power of a mobile phone is directly related to its radiofrequency (RF) electromagnetic field strength, and may theoretically vary substantially in different networks and phone use circumstances due to power control technologies. To improve indices of RF exposure for epidemiological studies, we assessed determinants of mobile phone output power in a multinational study. More than 500 volunteers in 12 countries used Global System for Mobile communications software-modified phones (GSM SMPs) for approximately 1 month each. The SMPs recorded date, time, and duration of each call, and the frequency band and output power at fixed sampling intervals throughout each call. Questionnaires provided information on the typical circumstances of an individual's phone use. Linear regression models were used to analyse the influence of possible explanatory variables on the average output power and the percentage call time at maximum power for each call. Measurements of over 60,000 phone calls showed that the average output power was approximately 50% of the maximum, and that output power varied by a factor of up to 2 to 3 between study centres and network operators. Maximum power was used during a considerable proportion of call time (39% on average). Output power decreased with increasing call duration, but showed little variation in relation to reported frequency of use while in a moving vehicle or inside buildings. Higher output powers for rural compared with urban use of the SMP were observed principally in Sweden where the study covered very sparsely populated areas. Average power levels are substantially higher than the minimum levels theoretically achievable in GSM networks. Exposure indices could be improved by accounting for average power levels of different telecommunications systems. There appears to be little value in gathering information on circumstances of phone use other than use in very sparsely populated regions.
  Occupational and environmental medicine 06/2009; 66(10):664-71. · 3.64 Impact Factor