Steffen Diehl
Research interests
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InterestsCTA, Interventional Radiology, Interventional Magnetic Resonance Imaging, Inteventional Oncology
Publications
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Placement of an aortomonoiliac stent graft without femorofemoral revascularization in endovascular aneurysm repair: a case report.
Journal of medical case reports. 08/2011; 5:365.
ABSTRACT: Endovascular aortic repair, if technically feasible, is the treatment of choice for patients with a contained ruptured aortic aneurysm who are unfit for open surgery. We report the case of an 80-year-old Caucasian man who presented with an unusually configured, symptomatic infrarenal aorti... [more] ABSTRACT: Endovascular aortic repair, if technically feasible, is the treatment of choice for patients with a contained ruptured aortic aneurysm who are unfit for open surgery. We report the case of an 80-year-old Caucasian man who presented with an unusually configured, symptomatic infrarenal aortic aneurysm. His aneurysm showed an erosion of the fourth lumbar vertebra and a severely arteriosclerotic pelvic axis. A high thigh amputation of his right leg had been performed 15 months previously. On his right side, occlusion of his external iliac artery, common femoral artery, and deep femoral artery had occurred. His aneurysm was treated by a left-sided aortomonoiliac stent graft without femorofemoral revascularization, resulting in occlusions of both internal iliac arteries. No ischemic symptoms appeared, although perfusion of his right side was maintained only over epigastric collaterals. The placement of aortomonoiliac stent grafts for endovascular treatment of infrarenal aortic aneurysms without contralateral revascularization is a feasible treatment option in isolated cases. In this report, access problems and revascularization options in endovascular aneurysm repair are discussed.
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0.48Impact points
[Complications of venous port systems : Radiological diagnostics and minimally invasive therapy].
Der Radiologe. 05/2011; 51(5):397-402, 404.
Documentation of a correct port placement is a routine investigation in radiology. This article describes typical complications of port catheters and minimally invasive treatment options which can guarantee further use without complications. From January 2009 to May 2010 a surgical port placement wa... [more] Documentation of a correct port placement is a routine investigation in radiology. This article describes typical complications of port catheters and minimally invasive treatment options which can guarantee further use without complications. From January 2009 to May 2010 a surgical port placement was carried out on 174 patients at the University Clinic in Mannheim and of these, 52 patients were admitted to our institute for radiological imaging of the port. Minimally invasive treatment options are presented based on the observed port complications. Of the 52 patients 7 (13.5%) received a port catheter lysis. A successful port position correction was carried out in 3 (5.8%) patients with a malpositioned port catheter and port removal was recommended in 2 patients (3.8%) due to extensive arm venous thrombosis. A minimally invasive port catheter treatment allowed further use of the port system without operative revision in the corresponding patients. The measures were tolerated very well by the patients without postinterventional complications.
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4.85Impact points
First multimodal embolization particles visible on x-ray/computed tomography and magnetic resonance imaging.
Investigative radiology. 03/2011; 46(3):178-86.
Embolization therapy is gaining importance in the treatment of malignant lesions, and even more in benign lesions. Current embolization materials are not visible in imaging modalities. However, it is assumed that directly visible embolization material may provide several advantages over current embo... [more] Embolization therapy is gaining importance in the treatment of malignant lesions, and even more in benign lesions. Current embolization materials are not visible in imaging modalities. However, it is assumed that directly visible embolization material may provide several advantages over current embolization agents, ranging from particle shunt and reflux prevention to improved therapy control and follow-up assessment. X-ray- as well as magnetic resonance imaging (MRI)-visible embolization materials have been demonstrated in experiments. In this study, we present an embolization material with the property of being visible in more than one imaging modality, namely MRI and x-ray/computed tomography (CT). Characterization and testing of the substance in animal models was performed. To reduce the chance of adverse reactions and to facilitate clinical approval, materials have been applied that are similar to those that are approved and being used on a routine basis in diagnostic imaging. Therefore, x-ray-visible Iodine was combined with MRI-visible Iron (Fe3O4) in a macroparticle (diameter, 40-200 μm). Its core, consisting of a copolymerized monomer MAOETIB (2-methacryloyloxyethyl [2,3,5-triiodobenzoate]), was coated with ultra-small paramagnetic iron oxide nanoparticles (150 nm). After in vitro testing, including signal to noise measurements in CT and MRI (n = 5), its ability to embolize tissue was tested in an established tumor embolization model in rabbits (n = 6). Digital subtraction angiography (DSA) (Integris, Philips), CT (Definition, Siemens Healthcare Section, Forchheim, Germany), and MRI (3 Tesla Magnetom Tim Trio MRI, Siemens Healthcare Section, Forchheim, Germany) were performed before, during, and after embolization. Imaging signal changes that could be attributed to embolization particles were assessed by visual inspection and rated on an ordinal scale by 3 radiologists, from 1 to 3. Histologic analysis of organs was performed. Particles provided a sufficient image contrast on DSA, CT (signal to noise [SNR], 13 ± 2.5), and MRI (SNR, 35 ± 1) in in vitro scans. Successful embolization of renal tissue was confirmed by catheter angiography, revealing at least partial perfusion stop in all kidneys. Signal changes that were attributed to particles residing within the kidney were found in all cases in all the 3 imaging modalities. Localization distribution of particles corresponded well in all imaging modalities. Dynamic imaging during embolization provided real-time monitoring of the inflow of embolization particles within DSA, CT, and MRI. Histologic visualization of the residing particles as well as associated thrombosis in renal arteries could be performed. Visual assessment of the likelihood of embolization particle presence received full rating scores (153/153) after embolization. Multimodal-visible embolization particles have been developed, characterized, and tested in vivo in an animal model. Their implementation in clinical radiology may provide optimization of embolization procedures with regard to prevention of particle misplacement and direct intraprocedural visualization, at the same time improving follow-up examinations by utilizing the complementary characteristics of CT and MRI. Radiation dose savings can also be considered. All these advantages could contribute to future refinements and improvements in embolization therapy. Additionally, new approaches in embolization research may open up.
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0.71Impact points
Dual energy computed tomography angiography of a pulmonary embolized port catheter fragment.
Journal of cardiovascular medicine (Hagerstown, Md.). 01/2011; 12(1):62-3.
We present the case of a 64-year-old woman with a history of breast cancer who underwent explantation of a dysfunctional intravenous port system. At surgery a broken port catheter was found. A port catheter fragment embolized into the segmental artery of the posterobasal segment of the right inferio... [more] We present the case of a 64-year-old woman with a history of breast cancer who underwent explantation of a dysfunctional intravenous port system. At surgery a broken port catheter was found. A port catheter fragment embolized into the segmental artery of the posterobasal segment of the right inferior lobe, causing a wedge-shaped segmental perfusion defect in the corresponding segment. The catheter was removed by catheter intervention with a goose-neck snare.
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6.34Impact points
Peripheral arterial occlusive disease: evaluation of a high spatial and temporal resolution 3-T MR protocol with a low total dose of gadolinium versus conventional angiography.
Radiology. 10/2010; 257(3):879-87.
To evaluate a peripheral magnetic resonance (MR) angiographic protocol combining continuous table movement (CTM) MR angiography of the entire runoff vasculature with time-resolved (TWIST) 3-T MR angiography of the calves with a total gadolinium dose of 0.1 mmol per kilogram of body weight. In this r... [more] To evaluate a peripheral magnetic resonance (MR) angiographic protocol combining continuous table movement (CTM) MR angiography of the entire runoff vasculature with time-resolved (TWIST) 3-T MR angiography of the calves with a total gadolinium dose of 0.1 mmol per kilogram of body weight. In this retrospective institutional review board-approved study, 31 consecutive patients (22 men, nine women; mean age, 65 years ± 14 [standard deviation]) with peripheral arterial occlusive disease who had undergone a low-dose MR angiographic protocol that consisted of CTM MR angiography (repetition time msec/echo time msec, 2.4/1.0; 21° flip angle; voxel size, 1.2 mm(3); gadolinium dose, 0.07 mmol per kilogram of body weight) and TWIST MR angiography (2.8/1.1; 20° flip angle; voxel size, 1.1 mm(3); temporal resolution, 4.8-5.5 sec, gadolinium dose, 0.03 mmol/kg), as well as digital subtraction angiography (DSA), were included. Two radiologists rated image quality and stenosis degree on four-point scales. The accuracy of stenosis gradation and, specifically, the detection of high-grade stenoses (stenosis of 70%-99%) with CTM MR angiography alone and with the combined protocol were compared with accuracy of stenosis gradation and detection of high-grade stenoses with DSA. Means and standard deviations were calculated for all data. Interobserver agreement was determined with κ statistics. Positive and negative predictive values, sensitivity, specificity, and overall diagnostic accuracy were calculated for CTM MR angiography alone and for the combined protocol. For CTM MR angiography, image quality was good or excellent in 95.9% of vessel segments; for TWIST MR angiography, image quality was good or excellent in 94.3% and 97.8% of vessel segments for readers 1 and 2, respectively. The combined protocol resulted in high overall diagnostic accuracy of more than 80% for detection of stenosis and diagnostic accuracy of 93.5% for detection of high-grade vessel stenosis. Inclusion of TWIST MR angiography increased diagnostic value over that achieved with CTM MR angiography alone. A combined MR angiographic approach in which a low total gadolinium dose (0.1 mmol/kg) is used yields excellent image quality and is accurate in the diagnosis of peripheral arterial stenosis.
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3.59Impact points
Dual energy bone subtraction in computed tomography angiography of extracranial-intracranial bypass: feasibility and limitations.
European radiology. 10/2010; 21(4):750-6.
To assess the feasibility of dual energy (DE)-CTA images with DE-bone removal (DEBR) for visualization of extra- to intracranial (EC/IC) arterial bypass compared to digital subtraction angiography (DSA). Prospectively, 24 patients underwent DE-CTA and DSA for evaluation of EC/IC-bypass. Using 5-poin... [more] To assess the feasibility of dual energy (DE)-CTA images with DE-bone removal (DEBR) for visualization of extra- to intracranial (EC/IC) arterial bypass compared to digital subtraction angiography (DSA). Prospectively, 24 patients underwent DE-CTA and DSA for evaluation of EC/IC-bypass. Using 5-point scales (0=poor to 4=excellent) two examiners rated image quality, quality of bone removal, and vessel integrity of bypass for three segments (extracranial, trepanation, intracranial) in CTA images with and without DEBR in comparison to DSA. Scores were evaluated by Friedmann's- and post-hoc Wilcoxon rank test. Image quality was high in CTA with and without DEBR and DSA (3.78 ± 0.36, 3.78 ± 0.36, 3.27 ± 0.46). No significant bone remnants were present using DEBR. Mean scores of bypass visualization were not significantly different for the extra- and intracranial segments. However, in the trepanation segment pseudo-lesions of the bypass were present in DEBR-CTA (6 out 24 cases) with a negative effect on visualization scores compared to DSA (p < 0.05). CTA with DEBR for assessment of EC/IC-bypass is feasible with reliable removal of cranial bones. Readers should be aware of a potential pitfall showing focal pseudostenosis/-occlusion of the bypass close to bone at the trepanation margin.
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0.59Impact points
[Diagnostically relevant craniocervical vascular injury in trauma room CT : Results of an inter-observer comparison.]
Der Unfallchirurg. 04/2010;
PURPOSE: Injuries of the craniocervical vessels in multi-traumatized patients are rare but devastating and can lead to stroke and death; nevertheless the diagnostic assessment of these injuries is often not part of the CT trauma examination protocol. MATERIALS AND METHODS: A total of 44 out of 315 m... [more] PURPOSE: Injuries of the craniocervical vessels in multi-traumatized patients are rare but devastating and can lead to stroke and death; nevertheless the diagnostic assessment of these injuries is often not part of the CT trauma examination protocol. MATERIALS AND METHODS: A total of 44 out of 315 multi-traumatized patients were defined to be at high risk for vessel injuries. Two readers analyzed the CT angiography (CTA) with respect to 1.) type and extent of fractures and 2.) trauma-associated pathologies of the vessels from the aortic arch to the cerebrum. The CTs were presented as original scans with the possibility to view the multiplanar reconstructions. RESULTS: The two readers could detect 12 out of 14 and 14 out of 14 cervical fractures, respectively. Both readers could demonstrate 28 out of 28 fractures of the skull, skull base and extended facial fractures. The diagnostic evaluation of vessel diseases showed correct classification of the type of pathology in 8 out of 12 and 7 out of 12 cases for the two readers, respectively. CONCLUSIONS: CTA of the craniocervical vessels is an important tool for rapid detection of vessel injuries and diseases in trauma patients. Different types of fractures may indicate the need for focused attention to vessel injuries, but even if there are no fractures present dissection of internal carotid and vertebral arteries can occur.
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3.54Impact points
Graph-Matching Based CTA
Medical Imaging, IEEE Transactions on. 01/2010;
Separating bone, calcification, and vessels in computer tomography angiography (CTA) allows for a detailed diagnosis of vessel stenosis. This paper presents a new, graph-based technique that solves this difficult problem with high accuracy. The approach requires one native data set and one that is c... [more] Separating bone, calcification, and vessels in computer tomography angiography (CTA) allows for a detailed diagnosis of vessel stenosis. This paper presents a new, graph-based technique that solves this difficult problem with high accuracy. The approach requires one native data set and one that is contrast enhanced. On each data set, an attributed level-graph is derived and both graphs are matched by dynamic programming to differentiate between bone, on one hand side, and vessel/calcification on the other hand side. Lumen and calcified regions are then separated by a profile technique. Evaluation is based on data from vessels of pelvis and lower extremities of elderly patients. Due to substantial calcification and motion of patients between and during the acquisitions, the underlying approach is tested on a class of difficult cases. Analysis requires 3-5 min on a Pentium IV 3 GHz for a 700 MByte data set. Among 37 patients, our approach correctly identifies all three components in 80% of cases correctly compared to visual control. Critical inconsistencies with visual inspection were found in 6% of all cases; 70% of these inconsistencies are due to small vessels that have 1) a diameter near the resolution of the CT and 2) are passing next to bony structures. All other remaining deviations are found in an incorrect handling of the iliac artery since the slice thickness is near the diameter of this vessel and since the orientation is not in cranio-caudal direction. Increasing resolution is thus expected to solve many the aforementioned difficulties.
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1.23Impact points
Application of DC beads in hepatocellular carcinoma: clinical and radiological results of a drug delivery device for transcatheter superselective arterial embolization.
Onkologie. 01/2010; 33(1-2):31-7.
Application of a drug delivery device for transarterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC). Clinical and radiological treatment assessment. 24 patients with liver cirrhosis and uni- or multifocal HCC underwent TACE with doxorubicin beads (DC Bead). The underly-i... [more] Application of a drug delivery device for transarterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC). Clinical and radiological treatment assessment. 24 patients with liver cirrhosis and uni- or multifocal HCC underwent TACE with doxorubicin beads (DC Bead). The underly-ing cause of liver cirrhosis was hepatitis (A: n = 7; B: n = 10) or alcohol consumption (n = 7). Patients presented with Child Pugh stage A (n = 15) and B (n = 9). The mean intrahepatic tumor size, considering the sum of diameters of all lesions treated, was 3.83 cm (+/-2.4). Liver function and hematological parameters were documented before and after each TACE. Magnetic resonance imaging (MRI) was performed before and 4 weeks after TACE. The T1-w 3D volume-interpolated breathhold exam (VIBE) sequence was applied for evaluation of the therapy response. 24 patients received a total number of 69 TACE treatments with DC beads (mean dose 160 mg). The elevation of liver function parameters after treatment did not affect the patients' clinical condition. The T1-w VIBE sequence proved very valuable for assessment of the intrahepatic tumor spread. Post-contrast images enabled delineation of the viable HCC lesions, hence facilitating the selective transcatheter approach. The tumor marker a-fetoprotein (AFP), available in 19/24 patients, dropped from 347.5 to 299.5 ng/ml, without being a reliable predictor of treatment response. A decrease of tumor size after TACE from 3.83 (+/-2.40) to 3.01 cm (+/-2.67; p < 0.0001) was evident on the T1w-VIBE sequences. The mean follow-up period was 30 months. At the time of data analysis, 10 (42%) out of 14 patients were alive. TACE with DC beads in HCC offers a safe and efficient treatment resulting in tumor response within a very short time.
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3.54Impact points
Graph-Matching Based CTA.
IEEE transactions on medical imaging. 07/2009;
Separating bone, calcification, and vessels in computer tomography angiography (CTA) allows for a detailed diagnosis of vessel stenosis. This paper presents a new, graph-based technique that solves this difficult problem with high accuracy. The approach requires one native data set and one that is c... [more] Separating bone, calcification, and vessels in computer tomography angiography (CTA) allows for a detailed diagnosis of vessel stenosis. This paper presents a new, graph-based technique that solves this difficult problem with high accuracy. The approach requires one native data set and one that is contrast enhanced. On each data set, an attributed level-graph is derived and both graphs are matched by dynamic programming to differentiate between bone, on one hand side, and vessel/calcification on the other hand side. Lumen and calcified regions are then separated by a profile technique. Evaluation is based on data from vessels of pelvis and lower extremities of elderly patients. Due to substantial calcification and motion of patients between and during the acquisitions, the underlying approach is tested on a class of difficult cases. Analysis requires 3-5 minutes on a PentiumIV 3 GHz for a 700 MByte data set. Among 37 patients, our approach correctly identifies all three components in 80% of cases correctly compared to visual control. Critical inconsistencies with visual inspection were found in 6% of all cases. 70% of these inconsistencies are due to small vessels that have 1) a diameter near the resolution of the CT and 2) are passing next to bony structures. All other remaining deviations are found in an incorrect handling of the iliac artery since the slice thickness is near the diameter of this vessel and since the orientation is not in cranio-caudal direction. Increasing resolution is thus expected to solve many the aforementioned difficulties.
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1.95Impact points
Dual-Energy CT Angiography in Peripheral Arterial Occlusive Disease.
Cardiovascular and interventional radiology. 02/2009;
We sought to study the accuracy of dual-energy computed tomographic angiography (DE-CTA) for the assessment of symptomatic peripheral arterial occlusive disease of the lower extremity by using the dual-energy bone removal technique compared with a commercially available conventional bone removal too... [more] We sought to study the accuracy of dual-energy computed tomographic angiography (DE-CTA) for the assessment of symptomatic peripheral arterial occlusive disease of the lower extremity by using the dual-energy bone removal technique compared with a commercially available conventional bone removal tool. Twenty patients underwent selective digital subtraction angiography and DE-CTA of the pelvis and lower extremities. CTA data were postprocessed with two different applications: conventional bone removal and dual-energy bone removal. All data were reconstructed and evaluated as 3D maximum-intensity projections. Time requirements for reconstruction were documented. Sensitivity, specificity, accuracy, and concordance of DE-CTA regarding degree of stenosis and vessel wall calcification were calculated. A total of 359 vascular segments were analyzed. Compared with digital subtraction angiography, sensitivity, specificity, and accuracy, respectively, of CTA was 97.2%, 94.1%, and 94.7% by the dual-energy bone removal technique. The conventional bone removal tool delivered a sensitivity of 77.1%, a specificity of 70.7%, and an accuracy of 72.0%. Best results for both postprocessing methods were achieved in the vascular segments of the upper leg. In severely calcified segments, sensitivity, specificity, and accuracy stayed above 90% by the dual-energy bone removal technique, whereas the conventional bone removal technique showed a substantial decrease of sensitivity, specificity, and accuracy. DE-CTA is a feasible and accurate diagnostic method in the assessment of symptomatic peripheral arterial occlusive disease. Results obtained by DE-CTA are superior to the conventional bone removal technique and less dependent on vessel wall calcifications.
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1.23Impact points
Preoperative staging of rectal tumors: comparison of endorectal ultrasound, hydro-CT, and high-resolution endorectal MRI.
Onkologie. 06/2008; 31(5):230-5.
AIM: The aim of this study was to compare transrectal ultra-sound (TRUS), hydro-computed tomography (hydro-CT), and endorectal magnetic resonance imaging (MRI) in the preoperative staging of rectal cancer. PATIENTS AND METHODS: 23 patients with rectal adenocarcinoma underwent TRUS, hydro-CT, and MRI... [more] AIM: The aim of this study was to compare transrectal ultra-sound (TRUS), hydro-computed tomography (hydro-CT), and endorectal magnetic resonance imaging (MRI) in the preoperative staging of rectal cancer. PATIENTS AND METHODS: 23 patients with rectal adenocarcinoma underwent TRUS, hydro-CT, and MRI (1 Tesla) with endorectal coil. The results were correlated with the histopathological findings based on the TNM classification. RESULTS: T staging with TRUS, hydro-CT, and endorectal MRI correlated with the histopa-thological findings in 83% of patients (19/23). Tumors were overestimated by TRUS in 2/23 patients, by CT in 3/23, and by MRI in 3/23 patients. Tumor size was underestimated by TRUS in 2 patients, by CT and MRI in 1 case each. Local lymphatic node involvement was correctly diagnosed with CT and MRI in 87% and 83%, respectively. Using TRUS, false-negative results in the staging of lymph node involvement were seen in 3/23 patients, whereas 1 patient was over-staged. Using hydro-CT as well as endorectal MRI, overstaging of the local lymph nodes took place in 2/23 patients. CONCLUSION: All methods are limited because peritumoral inflammation cannot be precisely distinguished from infiltration by the tumor. Correct lymph node staging is hampered in advanced disease using TRUS. In these patients, further cross-sectional imaging may be required.
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0.48Impact points
[Cardiac MR imaging in arrhythmogenic heart diseases]
Der Radiologe. 05/2007; 47(4):325-32.
INTRODUCTION: Cardiac arrhythmias are assessed with a combination of history, clinical examination, electrocardiogram, Holter monitor, if necessary supplemented by invasive cardiac electrophysiology. In ischemic heart disease (IHD) coronary angiography is performed in addition. METHODS: Echocardiogr... [more] INTRODUCTION: Cardiac arrhythmias are assessed with a combination of history, clinical examination, electrocardiogram, Holter monitor, if necessary supplemented by invasive cardiac electrophysiology. In ischemic heart disease (IHD) coronary angiography is performed in addition. METHODS: Echocardiography is usually the primary imaging modality. MRI is increasingly recognized as an important investigation allowing more accurate cardiac morphological and functional assessment. RESULTS: Approximately one-fifth of deaths in Western countries are due to sudden cardiac death, 80% of which are caused by arrhythmias. Typical causes range from diseases with high prevalence (IHD in men 30%) to myocarditis (prevalence 1-9%) and rare cardiomyopathies (prevalence HCM 0.2%, ARVC 0.02%, Brugada syndrome approx. 0.5%). The characteristic MRI features of arrhythmogenic diseases and the new aspects of characteristic distribution of late enhancement allow etiologic classification and differential diagnosis. CONCLUSION: MRI represents an important tool for detection of the underlying cause and for risk stratification in many diseases associated with arrhythmias.
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0.48Impact points
[Negative endoscopy and MSCT findings in patients with acute lower gastrointestinal hemorrhage. Value of (99m)Tc erythrocyte scintigraphy]
Der Radiologe. 02/2007; 47(1):64-70.
PURPOSE: To evaluate the clinical use of (99m)Tc red blood cell imaging (RBC imaging) in patients presenting with acute lower gastrointestinal (GI) bleeding and negative endoscopy and multislice computed tomography (MSCT) findings. PATIENTS AND METHODS: In 31 consecutive patients with acute lower GI... [more] PURPOSE: To evaluate the clinical use of (99m)Tc red blood cell imaging (RBC imaging) in patients presenting with acute lower gastrointestinal (GI) bleeding and negative endoscopy and multislice computed tomography (MSCT) findings. PATIENTS AND METHODS: In 31 consecutive patients with acute lower GI bleeding in whom the endoscopy findings were negative or the procedure was not feasible, dual-phase MSCT of the abdomen was performed [collimation 4x1 mm (arterial phase), 4x2.5 mm (venous phase)]. MSCT was followed by a (99m)Tc red blood cell scan in patients in whom no active bleeding was visible by CT. Images were created within 24 h after administration of the tracer, depending on the clinical symptoms. The results of the imaging modalities were correlated with clinical course and surgical treatment. RESULTS: In 20 of 31 patients MSCT showed no active bleeding and a (99m)Tc red blood cell scan was performed. In 8 of 20 patients RBC imaging was also negative. Of these eight patients five were stable and did not require further diagnostic work-up; in the other three bleeding persisted and these patients required surgical treatment. In 12 of 20 patients active bleeding was demonstrated using a (99m)Tc red blood cell scan. Of 12 patients with positive RBC scintigraphy findings, 8 underwent surgery, where the site of bleeding was confirmed. CONCLUSION: In patients with acute lower GI bleeding with negative or nondiagnostic endoscopy or MSCT findings, (99m)Tc red blood cell imaging is a useful tool in an emergency algorithm, improving the overall bleeding detection rate.
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1.88Impact points
Multislice CT-angiography in percutaneous postinterventional hematuria and kidney bleeding: Influence of diagnostic outcome on therapeutic patient management. Preliminary results.
Archives of medical research. 02/2007; 38(1):126-32.
BACKGROUND: The aims of this study were to assess the value of multislice CT-angiography (MS-CT-A) in percutaneous postinterventional kidney bleeding and to determine the influence of diagnostic outcome on therapeutic patient management. A recommendation for the interdisciplinary patient work-up for... [more] BACKGROUND: The aims of this study were to assess the value of multislice CT-angiography (MS-CT-A) in percutaneous postinterventional kidney bleeding and to determine the influence of diagnostic outcome on therapeutic patient management. A recommendation for the interdisciplinary patient work-up for the emergency room was offered. METHODS: Between April 2003 and January 2006, 12 patients with hematuria and clinically suspected renal bleeding underwent MS-CT-A for emergency diagnostic assessment. The spectrum of kidney injuries on CT was analyzed according to an organ-scaling scheme. The efficacy of MS-CT-A with regard to confirmation of active arterial bleeding was evaluated as well as the therapeutic consequences for patient management. RESULTS: In seven patients (59%) staged grade V renal injury, active renal arterial bleeding was detected on CT-A. Patients immediately underwent therapeutic angiography with confirmation of arterial bleeding and successful embolization. Four patients (33%) were staged grade I renal injury with subcapsular kidney hematoma but no active hemorrhage. Therefore, these patients were not exposed to further therapeutic intervention. One patient (8%) was diagnosed grade II renal injury with superficial cortical renal parenchyma tear and no active bleeding on CT-A. CONCLUSIONS: MS-CT-A is a valuable, fast and objective emergency tool for assessment of postinterventional renal hemorrhage. Detection of contrast material extravasation to affirm ongoing arterial bleeding and to localize bleeding site at the level of segmental or interlobar renal artery is a predictor for the need for further treatment and justifies therapeutic radiological or surgical management.
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2.03Impact points
[Localization of bleeding using 4-row detector-CT in patients with clinical signs of acute gastrointestinal hemorrhage]
RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin. 01/2006; 177(12):1649-54.
PURPOSE: There is no gold-standard regarding the diagnostic work-up and therapy of an acute gastrointestinal (GI) hemorrhage. In most cases endoscopy provides the diagnosis but in a low percentage this modality is not feasible or negative. Purpose of this study was to evaluate the role of multi-phas... [more] PURPOSE: There is no gold-standard regarding the diagnostic work-up and therapy of an acute gastrointestinal (GI) hemorrhage. In most cases endoscopy provides the diagnosis but in a low percentage this modality is not feasible or negative. Purpose of this study was to evaluate the role of multi-phase Multi-Slice-Computertomography (MSCT) as a modality to diagnose and locate the site of acute GI hemorrhage in case of unfeasible or technically difficult endoscopy. MATERIALS AND METHODS: 58 patients, presenting with clinical signs of lower GI hemorrhage, were examined through a 24-month period. Preliminary endoscopy was either negative or unfeasible. Images were obtained with a four-detector row CT with an arterial (4 x 1 mm collimation, 0.8 mm increment, 1.25 mm slice width, 120 kV, 165 mAs) and portal venous series (4 x 2,5 mm collimation, 2 mm increment, 3 mm slice width, 120 kV, 165 mAs). Time interval between endoscopy and CT varied between 30 minutes and 3 hours. The results of the MSCT were correlated with clinical course and surgical or endoscopical treatment. RESULTS: 20 of the 58 patients (34 %) undergoing MSCT had a bleeding site identified, thus providing decisive information for the following intervention. In case of a following therapeutic intervention there was 100 % correlation regarding the bleeding site. In 38 of the 58 patients (66 %), a bleeding site was not identified by MSCT. Twenty of these 38 patients (53 %) were stable and required no further treatment. In 18 of these 38 patients further interventional therapy was required due to continuing hemorrhage and in all of those patients the bleeding site was detected by intervention. CONCLUSION: Compared to other diagnostic methods MSCT is a fast, widely-available and low-risk technique for the localization of active GI hemorrhage. The clinical use seems to be justified since in more than one third of the patients, MSCT demonstrates the site of bleeding and provides decisive information for further interventional therapy. Concerning those patients, in whom MSCT is negative (38 out of 58 patients), only every second patient requires any additional diagnostic work-up.
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2.03Impact points
[Whole-body MSCT of patients after polytrauma: abdominal injuries]
RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin. 01/2006; 177(12):1641-8.
PURPOSE: The goal of this retrospective study was to evaluate the spectrum of abdominal injuries and the reliability of computed tomography-based diagnosis in patients after polytrauma. MATERIAL AND METHODS: CT findings and clinical reports for 177 patients after polytrauma were evaluated with regar... [more] PURPOSE: The goal of this retrospective study was to evaluate the spectrum of abdominal injuries and the reliability of computed tomography-based diagnosis in patients after polytrauma. MATERIAL AND METHODS: CT findings and clinical reports for 177 patients after polytrauma were evaluated with regard to abdominal injuries. Clinical patient reports at the time of discharge from the hospital were utilized as the standard of reference. Abdominal injuries resulting from an accident, frequent additional traumas and following therapeutic procedures were recorded. In the case of discrepancies in the reports, the CT scans were viewed retrospectively. RESULTS: In 30 out of 177 patients, 42 abdominal injuries were detected. 69 % of the injuries were caused by traffic accidents while 31 % resulted from falls. Liver and spleen injuries were the most common. 50 % of the cases were treated surgically, and the other half of the cases underwent non-surgical conservative therapy. Massive chest traumas, pelvic injuries, cerebral traumas and injuries to extremities were commonly associated with abdominal injuries. Evaluation of the discrepancies in the clinical reports showed that injury to the pancreas and the small intestine were not successfully detected on CT, thus resulting in a false negative diagnosis. Early stages of organ parenchyma laceration were also initially misdiagnosed on CT. CONCLUSION: Contrast-enhanced whole-body MSCT is a reliable and rapid method for diagnosing abdominal injuries in patients after polytrauma. Only very few patterns of injury are not detected on CT. The appearance of fluid collection in the abdomen is an indicator of possible parenchyma injury and requires further evaluation in cases of clinically suspected organ trauma.
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1.23Impact points
Cross-sectional imaging combined with 3D-MR angiography (3D-MRA): diagnostic tool for preoperative vascular assessment of head and neck tumors.
Onkologie. 11/2005; 28(10):477-81.
BACKGROUND: Head and neck cancer accounts for 5% of all malignancies worldwide. The presence of lymph node metastases and vascular infiltration influence patient outcome. This prospective study describes the preoperative morphologic assessment of the vascular status of patients with head and neck tu... [more] BACKGROUND: Head and neck cancer accounts for 5% of all malignancies worldwide. The presence of lymph node metastases and vascular infiltration influence patient outcome. This prospective study describes the preoperative morphologic assessment of the vascular status of patients with head and neck tumors by means of high spatial resolution and extended coverage of the arterial and venous system reaching from the supra-aortic region to the skull base. PATIENTS AND METHODS: Cross-sectional imaging combined with contrast-enhanced 3D-maximum intensity projection MR angiography (3D-MRA) was applied using a dedicated head and neck coil with a 4-channel panorama array system interface to assess vascular involvement in patients with suspected head and neck cancer. 32 patients underwent preoperative assessment by magnetic resonance imaging (MRI). The results were then correlated with surgical and histological findings. RESULTS: 3 of the 32 patients (9%) demonstrated involvement of the arterial system. In 2 of these 3 cases, MRA correctly predicted the arterial status, while in 1 case it gave a false negative result. 11 of the 32 patients (34%) presented with involvement of the venous system. 10 cases showed complete concordance between the findings of the MR venography and the intraoperative status, while in 1 case a false negative result was produced. CONCLUSION: In patients with suspected head and neck tumors, 3D-MRA in combination with cross sectional imaging is a valuable diagnostic tool for the detection of vascular involvement.
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0.65Impact points
Diagnostic evaluation of magnetic resonance imaging with turbo inversion recovery sequence in head and neck tumors.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. 09/2005; 262(8):634-9.
The clinical outcome of patients with head and neck cancer depends on many factors such as tumor size, metastatic involvement and angioarchitecture of the tumor. The correct staging of tumor extension, presence of cervical lymph node metastases and evaluation of vascular infiltration are essential d... [more] The clinical outcome of patients with head and neck cancer depends on many factors such as tumor size, metastatic involvement and angioarchitecture of the tumor. The correct staging of tumor extension, presence of cervical lymph node metastases and evaluation of vascular infiltration are essential diagnostic steps before treatment. The aim of this study was to evaluate the accuracy of turbo inversion recovery magnitude (TIRM) magnetic resonance imaging (MRI) in the diagnosis of head and neck tumors with special attention to tumor size and tumor spread according to the current TNM classification. TIRM sequence with short T1 relaxation and long TE (echo time) improves imaging contrast because of the increased T1-weighting and the inherent fat suppression. In a prospective clinical study, 32 patients underwent preoperative MRI. Diagnosis was confirmed histologically in all cases. Scanning was performed on a 1.0-T unit applying TIRM as well as T1- and T2-weighted turbo spin echo (TSE) sequences. In all sequences, tumor size was overestimated due to reactive inflammatory changes surrounding the tumor tissue. The least overestimation was documented on TIRM and post-contrast T1 TSE. The highest values of relative tumor signal intensities were obtained in TIRM (3.5+/-0.9) and T2 TSE (3.5+/-0.8) followed by post-contrast T1 TSE (1.6+/-0.7) and pre-contrast T1 TSE (1.2+/-0.3). Due to the inherent fat suppression, tumor delineation was most obvious in TIRM. In patients with suspected cancer of the head and neck, TIRM should be considered as a standard and a diagnostically relevant sequence in the MRI staging protocol.
Following (6)
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Soenke Bartling
German Cancer Research Center / UMC Mannheim -
Inge Kaare Tesdal
UMM Universitätsmedizin Mannheim -
Maliha Sadick
Institute of Clinical Radiology and Nuclear Medicine -
Alexander Marx
UMM Universitätsmedizin Mannheim
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