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Proteins destined for secretion are first folded within the endoplasmic reticulum. The process of protein folding can become defective in many disease states such as hypoxia, malignancy and some forms of diabetes. When the level of misfolded proteins within the endoplasmic reticulum increases, the cell is said to experience 'endoplasmic reticulum stress'. We wish to understand the cellular consequences of endoplasmic reticulum stress, in particular its effects on tissue growth and cell survival.

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