Stefan J. Marciniak

Pulmonology, Molecular Biology, Cancer Research

PhD, MB BChir, FRCP, MA.
38.65

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Proteins destined for secretion are folded within the endoplasmic reticulum (ER). The process of protein folding can become defective in many disease states such as hypoxia, malignancy and diabetes. When the level of misfolded proteins within the ER increases, the cell is said to experience 'ER stress'. We wish to understand the cellular consequences of ER stress, in particular its effects on tissue growth and cell survival.

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