Stefan Jahnel

IMBA Institute Of Molecular Biotechnology · Mendjan lab

We provide here a detailed single cell transcriptomic atlas covering the life cycle of the cosmopolitan scyphozoan Aurelia coerulea . We show that there is an increase in cell type diversity in the medusa stage, which is reflected by an increase in the number of unique transcripts expressed. We highlight parallels in both cell complement and specif...

Animals are typically composed of hundreds of different cell types, yet mechanisms underlying the emergence of new cell types remain unclear. Here we address the origin and diversification of muscle cells in the non-bilaterian, diploblastic sea anemone Nematostella vectensis. We discern two fast and two slow-contracting muscle cell populations, whi...

Cardiac congenital disabilities are the most common organ malformations, but we still do not understand how they arise in the human embryo. Moreover, although cardiovascular disease is the most common cause of death globally, the development of new therapies is lagging compared with other fields. One major bottleneck hindering progress is the lack...

Organoids capable of forming tissue-like structures have transformed our ability to model human development and disease. With the notable exception of the human heart, lineage-specific self-organizing organoids have been reported for all major organs. Here, we established self-organizing cardioids from human pluripotent stem cells that intrinsicall...

Current in vitro systems are powerful tools for studying early heart specification but lack the ability to model morphological events. Reporting in this issue of Cell Stem Cell, Rossi et al. (2021) • Rossi G. • Broguiere N. • Miyamoto M. • Boni A. • Guiet R. • Girgin M. • Kelly R.G. • Kwon C. • Lutolf M.P. Capturing Cardiogenesis in Gastruloids....

The evolutionary mechanisms underlying the emergence of new cell types are still unclear. Here, we address the origin and diversification of muscle cells in the diploblastic sea anemone Nematostella vectensis . We discern two fast and two slow-contracting muscle cell populations in Nematostella differing by extensive sets of paralogous genes. The r...

Organoids that self-organize into tissue-like structures have transformed our ability to model human development and disease. To date, all major organs can be mimicked using self-organizing organoids with the notable exception of the human heart. Here, we established self-organizing cardioids from human pluripotent stem cells that intrinsically spe...

Introduction Nematostella vectensis, a member of the cnidarian class Anthozoa, has been established as a promising model system in developmental biology, but while information about the genetic regulation of embryonic development is rapidly increasing, little is known about the cellular organization of the various cell types in the adult. Here, we...