Stefan Borgwardt

Publications (113) View all

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  Available from: Stefan Borgwardt

  Article: Duration of untreated psychosis and cognitive functioning.

  Charlotte Rapp, Erich Studerus, Hilal Bugra, Jacqueline Aston, Corinne Tamagni, Anna Walter, Marlon Pflueger, Stefan Borgwardt, Anita Riecher-Rössler
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  ABSTRACT: BACKGROUND: Studies examining the influence of duration of untreated psychosis (DUP) or duration of untreated illness (DUI) on cognition vary with regard to results and methods. This study is the first in this field to include an at risk mental state with later transition to psychosis (ARMS-T) sample and to analyse how the DUI relates to their cognitive functioning. Because methodological operationalization of cognitive functioning in previous studies is highly heterogeneous, we aimed to compare different approaches. METHOD: 60 first episode psychosis (FEP) patients and 24 ARMS-T patients were examined. Associations between DUP, DUI and neurocognitive performance were tested by three different operationalizations of cognition: as the raw outcome measure of different neuropsychological tests, as outcome scores which were normed on a sample of 75 healthy participants, and as the deterioration index (DI). RESULTS: There were no significant correlations between DUP or DUI and outcome of neuropsychological tests in both normed and raw scores. When adjusted for covariates, DUP and DUI also did not significantly predict any cognitive performance. There was no significant relationship between DUP or DUI and the DI index. However, longer DUP and DUI were significantly associated with stronger negative symptoms. CONCLUSIONS: This study could not confirm an association between duration of untreated psychosis or duration of untreated illness and neurocognitive performance in the ARMS-T and FEP samples. This could be because schizophrenic psychoses are neurodevelopmental disorders in which most cognitive deficits exist long before the onset of psychiatric symptoms.
  Schizophrenia Research 02/2013; · 4.75 Impact Factor
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  Available from: Stefan Borgwardt

  Article: Neurochemistry Of Schizophrenia And Psychosis: The Contribution Of Neuroimaging.

  Stefan Borgwardt, Renata Smieskova
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  ABSTRACT: None.
  Current topics in medicinal chemistry 12/2012; · 4.47 Impact Factor
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  Available from: Anita Riecher-Rössler

  Article: The Psychosis High-Risk State: A Comprehensive State-of-the-Art Review.

  Paolo Fusar-Poli, Stefan Borgwardt, Andreas Bechdolf, Jean Addington, Anita Riecher-Rössler, Frauke Schultze-Lutter, Matcheri Keshavan, Stephen Wood, Stephan Ruhrmann, Larry J Seidman, [......], Lieuwe De Haan, Barbara Cornblatt, Ilaria Bonoldi, Max Birchwood, Thomas McGlashan, William Carpenter, Patrick McGorry, Joachim Klosterkötter, Philip McGuire, Alison Yung
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  ABSTRACT: CONTEXT During the past 2 decades, a major transition in the clinical characterization of psychotic disorders has occurred. The construct of a clinical high-risk (HR) state for psychosis has evolved to capture the prepsychotic phase, describing people presenting with potentially prodromal symptoms. The importance of this HR state has been increasingly recognized to such an extent that a new syndrome is being considered as a diagnostic category in the DSM-5. OBJECTIVE To reframe the HR state in a comprehensive state-of-the-art review on the progress that has been made while also recognizing the challenges that remain. DATA SOURCES Available HR research of the past 20 years from PubMed, books, meetings, abstracts, and international conferences. STUDY SELECTION AND DATA EXTRACTION Critical review of HR studies addressing historical development, inclusion criteria, epidemiologic research, transition criteria, outcomes, clinical and functional characteristics, neurocognition, neuroimaging, predictors of psychosis development, treatment trials, socioeconomic aspects, nosography, and future challenges in the field. DATA SYNTHESIS Relevant articles retrieved in the literature search were discussed by a large group of leading worldwide experts in the field. The core results are presented after consensus and are summarized in illustrative tables and figures. CONCLUSIONS The relatively new field of HR research in psychosis is exciting. It has the potential to shed light on the development of major psychotic disorders and to alter their course. It also provides a rationale for service provision to those in need of help who could not previously access it and the possibility of changing trajectories for those with vulnerability to psychotic illnesses.
  Archives of general psychiatry 11/2012; · 12.26 Impact Factor
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  Available from: Stefan Borgwardt

  Article: Molecular Bases Of Antipsychotic Drugs: The Contribution Of Neurosciences.

  Stefan Borgwardt, André Schmidt
  Current Medicinal Chemistry 11/2012; · 4.86 Impact Factor
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  Available from: Anita Riecher-Rössler

  Article: Whither the attenuated psychosis syndrome?

  Alison R Yung, Scott W Woods, Stephan Ruhrmann, Jean Addington, Frauke Schultze-Lutter, Barbara A Cornblatt, G Paul Amminger, Andreas Bechdolf, Max Birchwood, Stefan Borgwardt, [......], Masafumi Mizuno, Anthony P Morrison, Anita Riecher-Rössler, Raimo K R Salokangas, Larry J Seidman, Michio Suzuki, Lucia Valmaggia, Mark van der Gaag, Stephen J Wood, Thomas H McGlashan
  Schizophrenia Bulletin 11/2012; 38(6):1130-4. · 8.80 Impact Factor