Simon C Roe

Publications (59) View all

• Article: Feline Musculoskeletal Pain Index: Responsiveness and Testing of Criterion Validity.

  J Benito, B Hansen, V Depuy, G S Davidson, A Thomson, W Simpson, S Roe, E Hardie, B D X Lascelles
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  ABSTRACT: BACKGROUND: Progress in establishing if therapies provide relief to cats with degenerative joint disease (DJD)-associated pain is hampered by a lack of validated owner-administered assessment methods. HYPOTHESIS: That an appropriately developed subjective owner-completed instrument (Feline Musculoskeletal Pain Index-FMPI) to assess DJD-associated impairment would have responsiveness and criterion validity. ANIMALS: Twenty-five client-owned cats with DJD-associated pain. METHODS: FMPI responsiveness (ability to detect the effect of an analgesic treatment) and validity (correlation with an objective measure) were explored through a stratified, randomized, double blinded, placebo-controlled, crossover 10-week clinical study. Meloxicam was administered to effect pain relief. A linear mixed model, backward stepwise regression, and Pearson correlations were used to assess responsiveness and criterion validity with the assumption that the NSAID would increase activity. RESULTS: Positive responses of cats to placebo (P = .0001) and meloxicam treatment (P = .0004) were detected; however, the instrument did not detect any difference between placebo and meloxicam (linear mixed model), even for the high impairment cases. Percent meloxicam target dose administered, temperament, and total baseline FMPI score were covariates that most affected FMPI scores. Controlling for significant covariates, most positive effects were seen for placebo treatment. Positive treatment effects on activity were detected, but only for the cases designated as most highly impaired. CONCLUSIONS AND CLINICAL IMPORTANCE: Neither responsiveness nor criterion validity were detected by the inclusion criteria for cases in this study. The data suggest that further work is indicated to understand factors affecting activity in cats to optimize inclusion criteria.
  Journal of Veterinary Internal Medicine 04/2013; · 1.99 Impact Factor
• Article: Reliability and discriminatory testing of a client-based metrology instrument, feline musculoskeletal pain index (FMPI) for the evaluation of degenerative joint disease-associated pain in cats.

  J Benito, V Depuy, E Hardie, H Zamprogno, A Thomson, W Simpson, S Roe, B Hansen, B D X Lascelles
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  ABSTRACT: The objective of this study was to test the readability, reliability, repeatability and discriminatory ability of an owner-completed instrument to assess feline degenerative joint disease (DJD)-associated pain (feline musculoskeletal pain index, FMPI). Readability was explored using four different formulas (Flesch, Fry, SMOG and FOG) and the final FMPI instrument was produced. To assess the instrument, client-owned cats that were defined as normal (normal group) or as having DJD-associated pain and mobility impairment (pain-DJD group) were recruited. A total of 32 client-owned cats were enrolled in the study (normal, n=13; pain-DJD, n=19). Owners completed the FMPI on two occasions, 14days apart. Internal consistency (reliability) and repeatability (test-retest) were explored using Cronbach's α and weighted κ statistic, respectively. Data from the two groups were compared using analysis of covariance (controlling for age) to evaluate discriminatory ability. The FMPI was constructed with 21 questions covering activity, pain intensity and overall quality of life. It had a 6th grade readability score. Reliability of the FMPI was excellent (Cronbach's α>0.8 for all groupings of questions in normal and pain-DJD cats) and repeatability was good (weighted κ statistic >0.74) for normal and pain-DJD cats. All components of the FMPI were able to distinguish between normal cats and cats with DJD (P<0.001 for all components). This initial evaluation of the FMPI suggests that this instrument is worthy of continued investigation.
  The Veterinary Journal 01/2013; · 2.24 Impact Factor
• Article: Influence of screw insertion order on compression generated by bone plates in a fracture model.

  K Jermyn, S C Roe
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  ABSTRACT: Present recommendations regarding order of screw insertion for compression plate osteosynthesis in veterinary training are variable. We hypothesized that placement of a neutrally positioned screw would reduce the magnitude of compression that could be generated by a subsequently placed compression screw. Canine tibial diaphyseal segments were fixed to a plate attached to a bone surrogate and load cell, and the compression generated by screw tightening was measured. Three different screw insertion order patterns were evaluated using both dynamic compression plate (DCP) and limited contact dynamic compression plate (LC-DCP) implants. In group CN, the first screw was placed in compression mode and the second in neutral mode; in group NC, the first screw was placed in neutral mode and the second in compression mode; in group LNC, the first screw was placed partially tightened in neutral mode and the second in compression mode followed by complete tightening of the neutral screw. Screw insertion order significantly influenced the amount of compression generated with both groups CN and LNC demonstrating significantly greater compression generation when compared with group NC (p <0.0001). Compression generated by group CN constructs was also significantly greater than group LNC (p = 0.0013). Evaluation of group CN data to assess the influence of plate and drill guide combinations on compressive force generated did not demonstrate a statistically significant difference. To maximize compression using a load screw in a bone plate, following securement of the opposite bone fragment to the plate, it should be placed before a neutral screw is placed.
  Veterinary and Comparative Orthopaedics and Traumatology 09/2011; 24(6):403-7. · 0.81 Impact Factor
• Article: Resistance to Subsidence of an Uncemented Femoral Stem After Cerclage Wiring of a Fissure.

  Ryan S McCulloch, Simon C Roe, Denis J Marcellin-Little, Peter L Mente
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  ABSTRACT: Objective: To compare: (1) the force required to initiate subsidence, and (2) the relative subsidence, of femoral stems implanted into intact femora, and then into the same femora in which an induced fissure had been stabilized by cerclage. Study Design: In vitro, mechanical study. Sample Population: Femora (n=9) from 9 dogs. Methods: Femora were prepared for implantation of an uncemented stem. Stems were implanted with continuous and impact loading. After axial loading until a fissure occurred, the stems were extracted, and the fissure stabilized with double-loop cerclage. Stems were reimplanted, and reloaded to failure. Results: Mean±SD load to initiate subsidence in intact femora was 1706±584 N compared with 2379±657 N for cerclaged bones (P=.002). Mean relative subsidence of intact femora was 3.99±2.09 mm compared with 1.79±2.99 mm for cerclaged bones (P=.091). Conclusions: The load to initiate subsidence is increased in femora that have fissured, then have been stabilized with double-loop cerclage, when compared with intact femora. The relative subsidence is not different between intact and stabilized specimens.
  Veterinary Surgery 07/2011; · 1.26 Impact Factor
• Article: Item generation and design testing of a questionnaire to assess degenerative joint disease-associated pain in cats.

  Helia Zamprogno, Bernie D Hansen, Howard D Bondell, Andrea Thomson Sumrell, Wendy Simpson, Ian D Robertson, James Brown, Anthony P Pease, Simon C Roe, Elizabeth M Hardie, Simon J Wheeler, B Duncan X Lascelles
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  ABSTRACT: To determine the items (question topics) for a subjective instrument to assess degenerative joint disease (DJD)-associated chronic pain in cats and determine the instrument design most appropriate for use by cat owners. 100 randomly selected client-owned cats from 6 months to 20 years old. Cats were evaluated to determine degree of radiographic DJD and signs of pain throughout the skeletal system. Two groups were identified: high DJD pain and low DJD pain. Owner-answered questions about activity and signs of pain were compared between the 2 groups to define items relating to chronic DJD pain. Interviews with 45 cat owners were performed to generate items. Fifty-three cat owners who had not been involved in any other part of the study, 19 veterinarians, and 2 statisticians assessed 6 preliminary instrument designs. 22 cats were selected for each group; 19 important items were identified, resulting in 12 potential items for the instrument; and 3 additional items were identified from owner interviews. Owners and veterinarians selected a 5-point descriptive instrument design over 11-point or visual analogue scale formats. Behaviors relating to activity were substantially different between healthy cats and cats with signs of DJD-associated pain. Fifteen items were identified as being potentially useful, and the preferred instrument design was identified. This information could be used to construct an owner-based questionnaire to assess feline DJD-associated pain. Once validated, such a questionnaire would assist in evaluating potential analgesic treatments for these patients.
  American Journal of Veterinary Research 12/2010; 71(12):1417-24. · 1.27 Impact Factor