Publications

  • European Journal of Internal Medicine 10/2013; Volume 24(Supp.1):1-278. · 2.30 Impact Factor
  • European Journal of Internal Medicine 10/2013; Volume 24: p.e1-e270-Supplement 1. · 2.30 Impact Factor
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    ABSTRACT: Aims: To analyze the clinical manifestations and outcome in four cases with nosocomial infection of Crimean-Congo hemorrhagic fever (CCHF) disease; treated at the Infectious Diseases Clinic in Prishtina (Kosovo). Material and Methods: In this retrospective study, the medical data’s and the history of four health care workers with CCHF were analyzed. The diagnose was confirmed by real-time polymerase chain reaction (RT-PCR). The health workers were engaged in the management of patients with severe forms of CCHF. Results: In all four cases the infection was caused by not following the protective measures.Three otolaryngology doctors were infected during tamponades of the nasal cavities of the patients with CCHF. Two of them did not wear any of the protective measures (the nasal tamponade was done without gloves and mask). The third doctor was not wearing the face shield and goggles with side shields (infection occurred after coughing blood drops that are deposited in the doctor's face. The fourth case was a laboratory hygienist which made cleaning test tubes with blood samples from patients with CCHF without the use of protective gloves. Mean incubation period of the disease was 6.2 days. Two cases manifested moderately severe disease by fever and other nonspecific symptoms including chills, severe headache, dizziness, neck pain, nausea, vomiting, myalgia, arthralgia without hemorrhagic syndrome. In two cases the disease had severe clinical manifestations with fever, other nonspecific symptoms and hemorrhagic syndrome which in one case ended with hemorrhagic shock and fatal outcome. Discussion and Conclusion: Kosovo is an endemic region, with frequent epidemic outbreaks and sporadic cases occurring with hospitalized case fatality of approximately 30%. CCHF is very contagious disease which is transmitted among the health workers by blood and other body fluids. Accidental infections are possible if strict universal precautions are not followed. Nosocomial infections can be serious and with possible fatal outcome.
    European Journal of Internal Medicine 10/2013; Volume 24: p.e1-e270-Supplement 1. · 2.30 Impact Factor
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    ABSTRACT: Qëllimi primar i aktiviteteve shkencore është përparimi i dijes në fusha të caktuara të hulumtimit, i cili dëshmohet me anë të publikimeve origjinale shkencore. Vlerësimi cilësor e sasior i të arriturave dhe rezultateve shkencore e të nivelit shkencor të shkencëtarëve vazhdon të jetë një sfidë e veçantë për komunitetin shkencor, si në Kosovë ashtu edhe në botë. Në faza të ndryshme të zhvillimit në të kaluarën, parametra të ndryshëm kanë vendosur për vlerësimin e cilësisë së rezultateve shkencore, respektivisht për nivelin e kontributit të rezultateve të caktuara shkencore në "shtimin" e dijes universale. Publikimi i "punimit origjinal shkencor", mbetet produkti kryesor në bazë të të cilit vlerësohet cilësia e punës shkencore të individit ose të grupit të caktuar shkencor, ndërkaq revista ku është botuar punimi, tregon për "nivelin" shkencor të autorit dhe të institucionit. Zhvillimi i shpejtë i informatikës dhe i internetit në vitet e fundit ka mundësuar kategorizimin dhe sistematizimin e rezultateve shkencore. Sot, platforma të ndryshme elektronike të shkencës dhe inovacionit mundësojnë gjetjen e shpejtë dhe përpunimin e informacionit të dëshiruar nga të gjitha fushat shkencore, duke ofruar të dhëna të rëndësishme për të arriturat shkencore të hulumtuesve të veçantë. Parametrat kryesorë në të cilët bazohet vlerësimi i të arriturave shkencore të hulumtueseve janë: numri i publikimeve, niveli i revistave shkencore (të indeksuara, me "impact factor" etj.) në të cilat publikohen artikujt shkencorë, numri i citimeve që e paraqet interesin e zgjuar te komuniteti shkencor për punën e autorit, si dhe parametrat e tjerë bashkëkohorë, si h-indexi etj. Fjalë çelës: aktivitet shkencor, impact factor, vlerësim, h index Key-words: scientific activity, impact factor, assessment, h index
    Takimi VIII vjetor ndërkombëtar i Institutit Alb-Shkenca - Konferenca e Seksionit të Shkencave të Natyrës, Tiranë, Albania; 08/2013
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    ABSTRACT: This investigation was carried out on the frequency of specific phenotypes as well as their eventual association in patients with H1N1. Data were obtained in the Clinics for Infectious Diseases – University Clinical Centre Prishtina, from the examination of 77 patients infected with H1N1 in the period 2010-2012 and compared with 101 control individuals. The selected alternative phenotypes analysed were: ear lobe free / ear lobe attached, normal chin /cleft chin, tongue roller/non roller, hand clasping right thumb over/ hand clasping left thumb over, righthanded /lefthanded, dark eyes/blue eyes. The blood group from ABO and Rh system as phenotypical markers were observed too. The results obtained show that the percentage of the individuals with attached ear lobe is significantly higher in patients (P<=0.01) compare to the control individuals. In addition, individuals with blue eyes are significantly more frequent (P<=0.05) among patients compare to control group whereas a tongue non-rollers are more represented in patients group (P<0.1). Although there was a difference in the percentage also in other characteristics, this was not statistically significant. There was no significant difference on the frequency of blood groups from the ABO and Rh system observed. The average age of the patients was 30.57 years As a conclusion, the recessive phenotypes are shown to be more frequent in H1N1 patients compare to control individuals indicating to eventually increased levels of homozygosity in some gene loci. Together with the fact that among 28 patients which developed complications, left-handed develop complications (mainly bronchopneumonia) significantly more often than right-handed (p<0.005), these preliminary data could serve as a good basis for further in depth investigations for better understanding of predispositions and susceptibility to H1N1.
    2013EACID; 05/2013
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    Dataset: MRI CT
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    ABSTRACT: In recent years, major technical progress has been achieved in cardiac MRI and CT, and these methods allow complete and non-invasive multiparametric characterization of the cardiovascular system. MRI uses the magnetic properties of the hydrogen nucleus, radio-waves and powerful magnets, whilst CT uses conventional X-rays but novel, either multi-detector spiral or electron beam technology for image generation. Both MRI and CT are gold standard methods for the three dimensional analysis of cardiothoracic anatomy, although MRI is superior in most situations. MRI is a very powerful technique for analysis of global and regional myocardial function, myocardial perfusion and viability imaging. CT, on the other hand, has the advantage for coronary imaging, where the solution is greater than that of MRI, up to 400µm2. At the present time, neither CT nor MRI can replace invasive coronary angiography. The value of coronary calcium scoring by CT remains to be established in prospective large scale clinical trials. It is likely that both MRI and CT will play a major role in diagnostic cardiology in the future.
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    ABSTRACT: (Full text is available at http://www.manu.edu.mk/prilozi). Cefixime is an oral third generation cephalosporin, frequently used in respiratory tract infections (RTI) in the pediatric population. However, in some publications cefixime has demonstrated poor efficacy against staphylococci and streptococci. The aim: of this study was to evaluate the efficacy of cefixime in the treatment of community-acquired infections in a country where parenteral third generation cephalosporins have been used for a long time. The present study was designed to assess the clinical efficacy, bacteriological eradication rates and tolerability of cefixime in children with community-acquired upper RTI (URTI), lower RTI (LRTI) and uncomplicated urinary tract infections (UTI). Materials and methods: The study was prospective, open, and included 89 patients, from 6 months to 28 years, of both sexes, with the diagnosis of community-acquired URTI, LRTI and UTI. Results: The treatment with cefixime was successful in 30/30 (100%) patients suffering from acute otitis media (AOM), in 10/12 (83.3%) with acute sinusitis, in 12/12 patients (100%) with pneumonia, in 31/35 (88.57) with uncomplicated UTI. The antibiotic was well tolerated. In 10 days treatment we recorded one case (1.3%) with acute gastroenteritis and two cases (2.6%) of maculopapular rash. Side-effects were transient and disappeared after finishing therapy in all three of the cases. Conclusions: Community-acquired infections, such as AOM, LRTI and UTI, caused by susceptible pathogens, can be treated with cefixime, as a good choice for a successful clinical response. Key words: cefixime, antimicrobial therapy, community-acquired infections.
    Prilozi / Makedonska akademija na naukite i umetnostite, Oddelenie za biološki i medicinski nauki = Contributions / Macedonian Academy of Sciences and Arts, Section of Biological and Medical Sciences 12/2011; 32(2):143-55.
  • Acta Informatica Medica 01/2010; Vloume 18(Issue 1).
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    ABSTRACT: Tuberculous meningitis is an infection of the the membranes covering the brain and spinal cord (meninges). Tuberculous meningitis is a major global health problem and is the most severe form of extrapulmonary tuberculosis, with high rate mortality. Last years in Kosovo incidence of TB was decreased in less than 1000 cases per year and 10-20 cases per year of TB meningoencephalitis. Still Kosovo has limited numbers of TB. TBM is diagnosed on the basis of clinical features, cerebrospinal fluid (CSF) studies, and radiological findings. Clinical picture, neurological status, anamnestic data, suspect (but not specific) lab tests, and imaging new methods, together can give very valuable help to clinicians for early adequate and successful treatment.
    Medical Archives 01/2010; 64(3):189-90.
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    ABSTRACT: With this study we want to evaluate the role of dexamethasone adjuvant treatment in different clinical forms of invasive meningococcal diseases. WORK METHODS: This was a randomized, open label trial that was conducted in 147 individuals with meningococcal sepsis. All of the cases have been divided in two groups: (1) Cases with meningococcal disease and CNS infection, and (2) Cases with meningococcal disease and no affection of the CNS. Cases from both groups were treated with dexamethasone, 0.15 mg/kg, every 6 h, for 4 (four) days, as adjuvant therapy. Cases which were not treated with dexamethasone were used as control group. From overall number of cases, in 130 of them, the meningococcal disease was accompanied with meningitis; in other 17 cases only signs of sepsis were present. In both clinical forms, the dexamethasone was used in 92 cases. The higher mortality rate is registered among the cases without meningitis, 17.65%, compared with 6.92% which is registered among cases with meningitis. The overall mortality rate among all cases was 8.2%. The significant difference was recorded only on CSF sugar level between two groups (treated or not with dexamethasone) on the day 1-4 of the hospitalization. Our epidemiological data are in correlation with data from other epidemiological studies. Most of the cases 69.4%, were more than 12 hours sick at home before the hospitalization, 7.5 % of cases were hospitalized within 12 hours from the onset of the diseases, while 23.1% of cases data are missing. This is in correlation with similar data from other studies. Dexamethasone has a limited effect on outcome of the invasive meningococcal disease. Dexamethasone had some effect only during the days of administration in cases with clinical form of sepsis with meningitis, by normalizing the values of CSF sugar earlier.
    Medical Archives 01/2010; 64(4):228-30.
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    ABSTRACT: Thrombosis of the sinuses is a distinct cerebrovascular disorder that, unlike arterial stroke, most often affects young adults and children. The symptoms and clinical course are highly variable. During the past decade, increased awareness of the diagnosis, improved neuro-imaging techniques, and more effective treatment have improved the prognosis. More than 80% of all patients now have a good neurologic outcome. This review summarizes recent insights into the pathogenesis of sinus thrombosis, risk factors, and clinical and radiological diagnosis and discusses the current evidence and controversies about the best treatment.
    Medical Archives 01/2010; 64(1):60-1.
  • Sadie Namani, Remzie Koci, Shemsedin Dreshaj, SanijeHoxha
    Internet Journal of Infectious Diseases 01/2009;
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    A Mustafa, A Heta, B Kastrati, Sh Dreshaj
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    ABSTRACT: We review and discuss the results of treatments for complications of cholesteatomatous chronic otitis media (CCOM) in a tertiary health care center. In a retrospective study, the medical records of patients with complications of CCOM who had undergone surgical treatment at the ENT Clinic of the University Clinical Center of Kosovo for the period 1994-2004 were reviewed. From a total of 1,803 patients suffering from CCOM, in 91 patients, 55 (60.4%) men and 36 (39.6) women, one or two complications are recorded. The mean age of the subjects was 30 years, and the age range was from 1 to 76 years. Extracranial (EC) complications were observed in 52 cases (57.1%), and intracranial (IC) complications were seen in 29 patients (31.9%). Twelve patients (11%) had multiple complications. For the EC cases, we found that subperiostal mastoidal abscess occurred in 26% of the all patients, facial nerve palsy was seen in 16.48% and labyrinthine fistula occurred in 10%. For the IC cases, meningitis (19.7%) and perisinusal abscess (15.3%) were the most common complications. The most often isolated pathogen from ear swabs was Proteus mirabilis in 33.3% of cases. The most frequent radiological diagnostic procedures were mastoid tip X-rays, which were performed in 77% of the patients, and computed tomography in 24%; magnetic resonance imaging was not performed on any of the patients during the study period. Patients with EC complications were treated in the ENT Clinic, whereas patients with IC complications, after otologic surgical procedures, were transferred to the Neurosurgery Clinic or to the Clinic for Infectious Diseases. In this series, three patients (3.3%) died as a result of complications, while the remaining 96.7% survived. Complications of COM with cholesteatoma can represent life-threatening conditions, and close cooperation between otosurgeons, neurosurgeons and infectious disease specialists is mandatory.
    Archives of Oto-Rhino-Laryngology 06/2008; 265(12):1477-82. · 1.29 Impact Factor

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