Publications (11) View all
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Article: High Serum YKL-40 Level in Patients with COPD Is Related to Hypoxemia and Disease Severity.
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ABSTRACT: Chronic obstructive pulmonary disease (COPD) is a major health problem with increasing morbidity and mortality throughout the world. YKL-40 is a chitin-binding glycoprotein consisting of 383 amino acids, with a molecular mass of 40 kDa, and its serum level is elevated in inflammatory diseases. YKL-40 is a newly recognized biomarker of inflammation and has not been thoroughly investigated in COPD. The aim of the study is to investigate the relationship between serum YKL-40 levels and severity of COPD. The study population consisted of 52 patients with COPD with the mean age of 60.2 ± 10.1 years. The serum YKL-40 level increased significantly with increasing age (p = 0.022, r = 0.346). In COPD patients, high serum YKL-40 level is correlated to low forced expiratory volume at 1 second (FEV(1), percent of predicted) (r = -0.277, p = 0.047). Moreover, high serum YKL-40 level is correlated to low arterial oxygen pressure (PaO(2), mmHg) (r = -0.387, p = 0.005). The mean serum YKL-40 level was found as 243.1 ± 129.2 ng/ml in COPD patients with desaturation during 6-minute walk test (6MWT) and this value was higher than the mean serum YKL-40 level (155.8 ± 59.1 ng/ml) of COPD patients without desaturation during 6MWT (p = 0.004). This study demonstrated that high serum YKL-40 levels were correlated to severity of COPD. We propose that circulating YKL-40 levels could be a biomarker for hypoxemia and decline in lung function.The Tohoku Journal of Experimental Medicine 01/2013; 229(2):163-70. · 1.24 Impact Factor -
Article: Plasma viscosity levels in pulmonary thromboembolism.
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ABSTRACT: Genetic and acquired thrombophilic risk factors may play role on developing venous thromboembolism (VTE). In many cases of pulmonary thromboembolism (PE) it can not be defined any explicit risk factor. In this study we aimed to identify the role of plasma viscosity level on PE. The investigation was planned prospectively and 33 patients with PE and 36 apparently healthy and nonsmoker volunteers as control group were enrolled in the study. The mean plasma viscosity levels were determined in patients with PE and in healthy volunteers as 1.42 ± 0.30 cP and 1.29 ± 0.22 cP respectively. The mean plasma viscosity levels was found to be different between PE and healthy group (p = 0.009). The mean levels of triglyceride, fibrinogen and hematocrit were found different between patients with PE and control group (p < 0.05). Variables including sex, age, smoking habits, levels of hematocrit, fibrinogen, total cholesterol and triglyceride were not associated with plasma viscosity values in patients with PE. Plasma viscosity levels were found higher in patients with PE compared with healthy indivudials. But it is needed to further studies to define the interactions between factors effecting blood rheology and development of thrombosis.Clinical hemorheology and microcirculation 10/2012; · 3.40 Impact Factor -
Article: Analysis of false positive positron emission tomography with 2-fluoro (18-F)-2-deoxy-D glucose as a tracer in patients with suspected lung cancer
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ABSTRACT: Accurate diagnosis of lung cancer is a critical factor determining operability in patients with non-small cell lung cancer (NSCLC). Positron emission tomography with 2-fluoro (18F)-2-deoxy-D glucose as a tracer (FDG-PET) has been reported to be effective in detecting tumor and involvement in mediastinal and hilar lymph nodes. In this study, we analyzed the accuracy of FDG-PET in pulmonary lesions which were suspected as lung cancer and mediastinal lymph node involvements. Forty patients with pulmonary lesions which were suspected as lung cancer underwent preoperative analysis including thoracic computerized tomography (CT), and wholebody FDG-PET were evaluated retrospectively. All patients underwent surgical resection of primary tumors and hilar and/or mediastinal lymph nodes between 2009 and 2010. A total of 40 resected and histologically examined pulmonary specimens were used for analysis which were all reported as FDG-PET positive and suspected lung cancer preoperatively. Thoracotomy was performed for treatment or diagnosis. Thirtyfour of them were NSCLC, one of them was schwannoma, three of the patients were tuberculosis, one had chronic and active nonspesific infection, and the last one had severe dysplasia and granulomatous reaction. In this study, the sensitivity and the specificity of FDG-PET was calculated as 86 and 68%, respectively. FDG-PET illuminates the physicians in diagnosis of lung cancer and staging of mediastinal or hilar lymph nodes. However, as a differantial diagnosis, active pulmonary tuberculosis and other granulomatous or inflamatory diseases should be thought in FDG-PET positive patients before desicion to thoracotomy.African journal of pharmacy and pharmacology 03/2012; 0,839(10-6):731-736. · 0.84 Impact Factor -
Article: Intralobar pulmonary sequestratıon as an unusual cause of recurrent hemoptysis.
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ABSTRACT: Pulmonary sequestration is an embryonic, cystic lung tissue that is supplied by systemic blood circulation. It is a nonfunctional lung parenchyma unconnected to normal tracheobronchial system. In cases of pulmonary sequestration, surgical interventions should be performed in order to prevent possible complications such as massive hemoptysis and infections. Preoperative imaging and treatment planning should be done carefully. We present an uncommon case of recurrent hemoptysis caused by intralobar pulmonary sequestration located in the left lower lobe.Journal of clinical imaging science. 01/2012; 2:71. -
Article: Diagnostic value of mycobacteriophage based fast plaque technique for early detection of pulmonary tuberculosis
01/2012;
