Publications (10) View all
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Article: Clinical predictors and outcome of metabolic acidosis in under-five children admitted to an urban hospital in Bangladesh with diarrhea and pneumonia.
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ABSTRACT: Clinical features of metabolic acidosis and pneumonia frequently overlap in young diarrheal children, resulting in differentiation from each other very difficult. However, there is no published data on the predictors of metabolic acidosis in diarrheal children also having pneumonia. Our objective was to evaluate clinical predictors of metabolic acidosis in under-five diarrheal children with radiological pneumonia, and their outcome. We prospectively enrolled all under-five children (n = 164) admitted to the Special Care Ward (SCW) of the Dhaka Hospital of icddr, b between September and December 2007 with diarrhea and radiological pneumonia who also had their total serum carbon-dioxide estimated. We compared the clinical features and outcome of children with radiological pneumonia and diarrhea with (n = 98) and without metabolic acidosis (n = 66). Children with metabolic acidosis more often had higher case-fatality (16% vs. 5%, p = 0.039) compared to those without metabolic acidosis on admission. In logistic regression analysis, after adjusting for potential confounders such as age of the patient, fever on admission, and severe wasting, the independent predictors of metabolic acidosis in under-five diarrheal children having pneumonia were clinical dehydration (OR 3.57, 95% CI 1.62-7.89, p = 0.002), and low systolic blood pressure even after full rehydration (OR 1.02, 95% CI 1.01-1.04, p = 0.005). Proportions of children with cough, respiratory rate/minute, lower chest wall indrawing, nasal flaring, head nodding, grunting respiration, and cyanosis were comparable (p>0.05) among the groups. Under-five diarrheal children with radiological pneumonia having metabolic acidosis had frequent fatal outcome than those without acidosis. Clinical dehydration and persistent systolic hypotension even after adequate rehydration were independent clinical predictors of metabolic acidosis among the children. However, metabolic acidosis in young diarrheal children had no impact on the diagnostic clinical features of radiological pneumonia which underscores the importance of early initiation of appropriate antibiotics to combat morbidity and deaths in such population.PLoS ONE 01/2012; 7(6):e39164. · 4.09 Impact Factor -
Chapter: Hypoglycemia in Children Attending the Critical Care Medicine in Developing Countries
11/2011; , ISBN: 978-953-307-652-2 -
Article: Hereditary spherocytosis.
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ABSTRACT: A 12-year-old girl was brought to the Dhaka Hospital of ICDDR,B with diarrhoea. Incidentally, the parents provided a history of repeated episodes of pallor and jaundice since she was two and half years old. Three of her family members had similar problems. History, clinical examination, and laboratory findings of the girl and her family members suggested a case of hereditary spherocytosis. To our knowledge, this is the first report of such a case in Bangladesh.Journal of Health Population and Nutrition 02/2010; 28(1):107-9. · 0.95 Impact Factor -
Article: High-dose intravenous dexamethasone in the management of diarrheal patients with enteric fever and encephalopathy.
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ABSTRACT: We conducted a retrospective chart analysis of diarrheal patients with enteric fever and encephalopathy (among survivors and non-survivors) to examine the role of high-dose, intravenous dexamethasone as an adjunct to appropriate antimicrobial therapy in their management. We studied all patients admitted to the Special Care Ward (SCW) of Dhaka Hospital between October 2006 and October 2007 with a diagnosis of encephalopathy in association with enteric fever. Twenty-three cases were identified with three mortalities. All bacterial isolates (Salmonella Typhi and Salmonella Paratyphi) were multi-drug resistant. Survivors were significantly more likely to have received high dose dexamethasone (100% vs 00%; p < 0.001) and had hypoglycemia less often (6% vs 67%; p = 0.045) compared to those who died. The results suggest high dose intravenous dexamethasone, as an adjunct to appropriate antimicrobial therapy, substantially reduces mortality among diarrheal patients presenting with enteric encephalopathy.The Southeast Asian journal of tropical medicine and public health 09/2009; 40(5):1065-73. · 0.60 Impact Factor -
Article: Presumptive shigellosis: Clinical and laboratory characteristics of Bangladeshi patients
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ABSTRACT: The aim of the study was to examine some selected clinical and laboratory parameters in distinguishing non-Shigella invasive diarrhoeas from culture-confirmed Shigella cases. We conducted a clinic-based, cross-sectional study at the Dhaka Hospital of ICDDR,B located in Bangladesh. In total, 389 patients of all age groups and of both genders, with a history of diarrhoea of less than 96 h and presence of visible blood and/or mucus in the stool were presumed to have shigellosis and enrolled in the study. Shigella was isolated from faecal cultures in 227 (58.4%) patients. The remaining 162 (41.6%) patients did not have Shigella isolated from their faecal cultures and constituted the comparison group. Another 238 randomly selected patients with non-Shigella diarrhoea from the Diarrhoeal Disease Surveillance System database of the Dhaka Hospital constituted another comparison group. Cases of culture-proven Shigella were similar to non-Shigella invasive diarrhoeal patients with presumptive shigellosis with regard to several biosocial variables. The nutritional status of children with shigellosis was significantly inferior to those with non-Shigella diarrhoea. The presence of macrophages more than 5/HPF in stool microscopic examination was significantly more frequent among patients infected with Shigella. Empirical antimicrobial therapy for shigellosis might be considered for malnourished diarrhoeal children presenting with history of visible blood and/or mucus in stool, and children older than 1 y of age. Further studies are needed in different geographical settings to identify clinical and laboratory parameters that could help identify patients with shigellosis.07/2009; 37(2):96-100.
