Publications (9) View all
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Article: Experimental bone defect healing with xenogenic demineralized bone matrix and bovine fetal growth plate as a new xenograft: radiological, histopathological and biomechanical evaluation.
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ABSTRACT: The following study was designed to evaluate xenogenic bovine demineralized bone matrix (DBM) and new xenograft (Bovine fetal growth plate) effects on bone healing process. Twenty male White New Zealand rabbits were used in this study. In group I (n = 10) the defect was filled by xenogenic DBM and in group II (n = 10) the defect was filled by a segment of bovine fetal growth plate and was fixed by cercelage wire. Radiological, histopathological, and biomechanical evaluations were performed blindly and results scored and analyzed statistically. Statistical tests did not support significant differences between two groups radiographically (P > 0.05). There was a significant difference for union at the 28th postoperative radiologically (P < 0.05). Xenograft was superior to DBM group at the 28th postoperative day for radiological union (P < 0.03). Histopathological and biomechanical evaluation revealed no significant differences between two groups. In conclusion, the results of this study indicate that satisfactory healing occurred in rabbit radius defect filled with xenogenic bovine DBM and xenogenic bovine fetal growth plate. Complications were not identified and healing was faster in two grafting groups.Cell and Tissue Banking 09/2008; 10(1):33-41. · 0.96 Impact Factor -
Article: Fresh cortical autograft versus fresh cortical allograft effects on experimental bone healing in rabbits: radiological, histopathological and biomechanical evaluation.
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ABSTRACT: Bone grafting is used to enhance healing in osteotomies, arthrodesis, and multifragmentary fractures and to replace bony loss resulting from neoplasia or cysts. They are source of osteoprogenitor cells and induce bone formation and provide mechanical support for vascular and bone ingrowth. Autografts are used commonly but quantity of harvested bone is limit. This study was designed to evaluate fresh cortical autograft and allograft effects on bone healing process. Twenty male White New Zealand rabbits were used in this study. In autograft group the defect was filled by fresh autogenous cortical graft, in allograft group the defect was filled by a segment of fresh allogenous cortical bone which was harvested at the time of surgery during the creation of radius bone defect. Then all surface soft tissue, such as muscle attachments, were removed from the harvested bone and changed between rabbits as a fresh allogenous cortical bone graft and was fixed by cercelage wire. Radiological, histopathological and biomechanical evaluations were performed blindly and results scored and analyzed statistically. Statistical tests did not support significant differences between two groups at the 14th and 56th postoperative day radiographically (P > 0.05). There was a significant difference radiologically for the 28th and the 42nd postoperative (P < 0.05). Autograft was superior to allograft at the 28th and 42nd postoperative day in radiological evaluation (P < 0.03). Histopathological and biomechanical evaluation revealed no significant differences between two groups.Cell and Tissue Banking 07/2008; 10(1):19-26. · 0.96 Impact Factor -
Article: Effect of bovine fetal growth plate as a new xenograft in experimental bone defect healing: radiological, histopathological and biomechanical evaluation.
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ABSTRACT: Bone grafting is used to enhance healing in osteotomies, arthrodesis, and multifragmentary fractures and to replace bony loss resulting from neoplasia or cysts. They are source of osteoprogenitor cells and induce bone formation and provide mechanical support for vascular and bone ingrowth. Autografts are used commonly but quantity of retrieved bone is limit. This study was designed to evaluate autograft and new xenograft (Bovine fetal growth plate) effects on bone healing process. Twenty male White New Zealand rabbits were used in this study. In autograft group the defect was filled by fresh autogenous cortical graft, in xenograft group the defect was filled by a segment of bovine fetal growth plate and was fixed by cercelage wire. Radiological, histopathological and biomechanical evaluations were performed blindly and results scored and analyzed statistically. Statistical tests did not support significant differences between two groups at the 14th and 28th postoperative day radiographically (P > 0.05). There was a significant difference for remodeling at the 42nd postoperative radiologically (P < 0.05). Xenograft was superior to autograft at the 56th postoperative day for radiological bone formation (P < 0.03). Histopathological and biomechanical evaluation revealed no significant differences between two groups. The results of this study indicate that satisfactory healing occurred in rabbit radius defect filled with calf fetal growth plate. Complications were not identified and healing was faster than cortical autogenous grafting. It was concluded that the use of calf fetal growth plate as a new xenograft is an acceptable alternative to cortical autogenous graft and could reduce the morbidity associated with harvesting autogenous graft during surgery.Cell and Tissue Banking 06/2008; 9(2):91-9. · 0.96 Impact Factor -
Article: Biologic resurfacing of the patella with quadriceps tendon flap: a rabbit study.
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ABSTRACT: In this experimental study, 10 rabbits underwent arthrotomy with exposure of the patellar bone (group A), 10 rabbits underwent arthrotomy of the right knee without touching the patella (group B), and 10 rabbits comprised the control group (group C), which was included only for evaluation of functional scoring activities. A 2-mm thick flap of quadriceps tendon reflected downward to cover the patellar bone denuded of cartilage, which resulted in formation of hyaline cartilage in 87% of cases in group A and 89% in group B, incomplete differentiation of the mesenchymal tissue in 7% in group A and 9% in group B, and fibrous tissue or bone formation in 6% in group A and 2% in group B. In group A, 22% of formed cartilage had a regular surface, 22% had superficial horizontal lamination, 44% had fissuring, and 12% showed severe disruption. In group B, these values were 56%, 33%, 11%, and 0%, respectively. In group A, normal cellularity was noted in 33% of cases, slight hypocellularity in 67%, and no moderate hypocellularity. In group B, these values were 56%, 33%, and 11%, respectively. This procedure should be considered in young patients with loss of articular cartilage for whom other procedures or patellectomy are unsuitable solutions.The journal of knee surgery 02/2002; 15(4):223-6; discussion 226-7. -
Article: Kala azar with disseminated dermal leishmaniasis.
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ABSTRACT: In this report we summarize 5 cases of kala azar with disseminated dermal leishmaniasis. All had fever, hepatosplenomegaly, and disseminated skin lesions on admission. Maculopapular, pustular, and maculonodular eruptions were present, located mainly on the face and extremities. Innumerable amastigotes were demonstrated in the bone marrow and in the skin biopsies. All patients responded to Glucantime therapy.The American journal of tropical medicine and hygiene 03/1989; 40(2):150-3. · 2.59 Impact Factor
