Rolf Müller

Publications (188) View all

• Article: Isolation, Structure Elucidation, and Biological Activity of Maltepolides: Remarkable Macrolides from Myxobacteria.

  Herbert Irschik, Peter Washausen, Florenz Sasse, Jörg Fohrer, Volker Huch, Rolf Müller, Evgeny V Prusov
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  ABSTRACT: Epoxide "swing": A family of polyketide macrolactones originating from maltepolide E was discovered in Sorangium cellulosum So ce1485. Their structure was established by NMR experiments, molecular modeling, and X-ray crystallography. Maltepolides induce rather rare morphological changes in the dividing transformed cell lines (see picture in the background).
  Angewandte Chemie International Edition 04/2013; · 13.45 Impact Factor
• Article: Lorneic acids C and D, new trialkyl-substituted aromatic acids isolated from a terrestrial Streptomyces sp.

  Ritesh Raju, Oleksandr Gromyko, Viktor Fedorenko, Andriy Luzhetskyy, Rolf Müller
  The Journal of Antibiotics 04/2013; · 1.65 Impact Factor
• Article: Total Synthesis and Antibacterial Activity of Dysidavarone A.

  Björn Schmalzbauer, Jennifer Herrmann, Rolf Müller, Dirk Menche
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  ABSTRACT: A concise total synthesis of dysidavarone A possessing the new "dysidavarane" carbon skeleton has been accomplished by a convergent strategy, involving a stereoselective reductive alkylation of a Wieland-Miescher type ketone under Birch conditions and an advantageous intramolecular palladium-catalyzed α-arylation of a sterically hindered ketone. Dysidavarone A showed potent antimicrobial and antiproliferative activities based on characteristic morphological changes of treated cells.
  Organic Letters 02/2013; · 5.86 Impact Factor
• Article: An Alternative Isovaleryl CoA Biosynthetic Pathway Involving a Previously Unknown 3-Methylglutaconyl CoA Decarboxylase.

  Yanyan Li, Eva Luxenburger, Rolf Müller
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  ABSTRACT: Take a detour: An alternative pathway to synthesize isovaleryl coenzyme A (CoA) has recently been suggested in myxobacteria, which is highly active when leucine is limited. Each enzymatic step of this unprecedented route has now been characterized and a novel 3-methylglutaconyl CoA decarboxylase identified that has apparently evolved from CoA transferases.
  Angewandte Chemie International Edition 12/2012; · 13.45 Impact Factor
• Article: Juniperolide A: A New Polyketide Isolated from a Terrestrial Actinomycete, Streptomyces sp.

  Ritesh Raju, Oleksandr Gromyko, Viktor Fedorenko, Andriy Luzhetskyy, Alberto Plaza, Rolf Müller
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  ABSTRACT: A new linear polyketide, juniperolide A (1), was produced by the terrestrial actinomycete (Lv1-48) isolated from the rhizosphere of the plant Juniperus excelsa. The juniperolide A (1) structure contains a THP unit and a 3-amino-2,3,6-trideoxyhexose as the glycosidic moiety. Mosher's analysis was used for absolute stereochemistry determinations at C-2, C-8, C-20, and C-4', while the relative stereochemistry assignments of the remaining stereocenters were based on ROESY correlations and J-based coupling.
  Organic Letters 11/2012; · 5.86 Impact Factor