Publications (27) View all
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Article: Influence of a high-fat diet on gut microbiota, intestinal permeability and metabolic endotoxaemia.
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ABSTRACT: Lipopolysaccharide (LPS) may play an important role in chronic diseases through the activation of inflammatory responses. The type of diet consumed is of major concern for the prevention and treatment of these diseases. Evidence from animal and human studies has shown that LPS can diffuse from the gut to the circulatory system in response to the intake of high amounts of fat. The method by which LPS move into the circulatory system is either through direct diffusion due to intestinal paracellular permeability or through absorption by enterocytes during chylomicron secretion. Considering the impact of metabolic diseases on public health and the association between these diseases and the levels of LPS in the circulatory system, this review will mainly discuss the current knowledge about high-fat diets and subclinical inflammation. It will also describe the new evidence that correlates gut microbiota, intestinal permeability and alkaline phosphatase activity with increased blood LPS levels and the biological effects of this increase, such as insulin resistance. Although the majority of the studies published so far have assessed the effects of dietary fat, additional studies are necessary to deepen the understanding of how the amount, the quality and the structure of the fat may affect endotoxaemia. The potential of food combinations to reduce the negative effects of fat intake should also be considered in future studies. In these studies, the effects of flavonoids, prebiotics and probiotics on endotoxaemia should be investigated. Thus, it is essential to identify dietetic strategies capable of minimising endotoxaemia and its postprandial inflammatory effects.The British journal of nutrition 04/2012; 108(5):801-9. · 3.45 Impact Factor -
Article: [Health promotion and diabetes: discussing the adherence and motivation of diabetics that participate in health programs].
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ABSTRACT: The objective of the present study was to evaluate, by means of a systematic literature review, the adherence and motivation presented by diabetic patients that participate in health intervention programs, which stimulate the adoption of a healthy life style. The ingestion of an adequate diet and the increase in physical activity, focusing in the disease perception, considering the diabetic patient knowledge, making evident the recommendations that should be followed to reach a better life quality, demonstrating that it is possible to live well even if you have a chronic disease such as diabetes. A literature research in the main public health databases (Medline, Lilacs, Scielo, among others) was conducted from 1994 to 2006. A total of 37 studies focused in the interaction among the subject health and disease versus diabetes were selected. This study mentions some daily difficulties felt by the diabetic patient and his family to control the disease. These difficulties can directly affect the patient adhesion to the prescribed treatment. Therefore, the behavioral and emotional factors presented by each patient must be considered when the health activities are being planned to reach total assistance to this population.Ciencia & saude coletiva 03/2011; 16(3):2001-9. -
Article: [Relationship between nutrition factors and glycemic control in children and adolescents with type 1 diabetes mellitus].
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ABSTRACT: To identify nutritional factors that affected the glycemic control of the studied population. One hundred forty-six children and adolescents, aged 7 to 19 years, followed-up at the Division of Pediatric Endocrinology of the Hospital das Clínicas da Universidade Federal de Minas Gerais participated in the study.The diet of each participant was evaluated by means of a Quantitative Food Frequency Questionnaire, previously validated in a pilot-project. Glycemic control was assessed through the average of HbA1c results obtained six months prior to date of diet evaluation. Diets with high protein content, less saturated fats, and lower glycemic index (GI)/glycemic load (GL) had a positive effect on glycemic control. The consumption of sucrose and of free snacks provided by the school had a negative influence on glycemic control. The consumption of nutritionally adequate and low GI/GL diets favored glycemic control of the studied population.Arquivos brasileiros de endocrinologia e metabologia 03/2010; 54(3):319-25. · 0.68 Impact Factor -
Article: Effects of protein quality on appetite and energy metabolism in normal weight subjects.
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ABSTRACT: The purpose of this study was to compare the effects of consumption of different protein sources on food intake and energy expenditure in normal weight subjects. Breakfast preparations (casein, soy protein, whey protein or control) were ingested during seven consecutive days. Appetite, food intake, and energy expenditure were assessed. Casein consumption led to a lower energy intake than whey protein. There was lower energy intake on day 7 than on day 1 of the casein session. Soy protein preparations resulted in higher diet induced thermogenesis (DIT) than in control preparations. The respiratory quotient (RQ) obtained in the whey protein session was lower than the control and soy protein sessions. These results suggest that the consumption of different protein types leads to distinct effects on satiety (casein), DIT (soy protein), and/or RQ (whey protein).Arquivos brasileiros de endocrinologia e metabologia 02/2010; 54(1):45-51. · 0.68 Impact Factor -
Article: EFEITO DA TEMPERATURA NO CRESCIMENTO E NA ATIVIDADE METABÓLICA DE PSICROTRÓFICO ACIDIFICANTE ISOLADO DE LEITE
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ABSTRACT: A bactéria psicrotrófica, produtora de ácido, foi isolada de leite cru em ágar púrpura de bromocresol (PBC), após incubação a 7°C por 10 dias. A cultura ativa da bactéria foi inoculada em frascos erlenmeyers contendo leite esterilizado, resultando em 10³ células por mililitro. Os frascos erlenmeyers foram incubados a 4,7, 10,21, 25, 30 e 35°C por tempos variados, e o desenvolvimento bacteriano foi acompanhado pela contagem em meio ágar para contagem-padrão em placas (PCA), incubado a 25°C por 48 horas. Os dados do logaritmo do número de UFC/mI (valores de y) versus o tempo de incubação (valores de x) foram marcados em gráfico e os dados correspondentes à fase logarítmica de crescimento foram ajustados por análise de regressão. As taxas de crescimente (k) e os tempos de geração foram calculados nas respectivas temperaturas. A atividade metabólica da bactéria isolada foi observada, nas diferentes temperaturas, em razão da acidez titulável e da variação do pH durante o crescimento. A bactéria psicrotrófica acidificante apresentou crescimento e atividade metabólica mais intensos a 30°C, com tempo de geração de 45 minutos e taxa de crescimento (k) de 1,36 gerações por hora. A 7°C foi observado um tempo de geração de 13 horas e 15 minutos, com valor do k de, aproximadamente, 0,08 gerações por hora. A coagulação de amostras de leite, acidificadas com ácido lático e aquecidas a 86°C, ocorreu em pH equivalente a 5,98. A inoculação de 10³ células da bactéria por mililitro de leite esterilizado resultou em coagulação após, aproximadamente, 33 horas a 21°C, 15 horas a 25°C, 13 horas a 35°C e 11 horas a 30°C.Alimentos e Nutrição. 01/2009;
