Publications (8) View all
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Article: A case of brain abscess due to Entamoeba species, Eikenella corrodens and Prevotella species.
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ABSTRACT: We report a case of brain abscess due to multiple pathogens including Entamoeba species, Eikenella corrodens and Prevotella species. Patient had odontogenic infection without any site of amoebic infestation. Complete recovery was achieved with surgical treatment and antimicrobial therapy.British Journal of Neurosurgery 08/2008; 22(4):596-8. · 0.88 Impact Factor -
Article: Evaluation of urinary bladder function after acute spinal cord injury: an experimental study.
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ABSTRACT: The aim of this study was to evaluate the efficacy of early surgical decompression of acute spinal cord injury through the evaluation of urinary bladder function in rabbits. The study was done with 21 New Zealand male rabbits which were 9 to 12 months in age, and weighed an average of 2438 grams (range 2150 to 3550 g). The animals were assigned into four groups as follows: a control group (n=5), a laminectomy group (n=6), a 15-second compression group (n=5) and a 60-second compression group (n=5). A 60 gram compression force was applied on both compression groups with aneurysm clips. All rabbits were sacrificed seven days postoperatively. Urinary bladder tissues were dissected and in vitro relaxation and contraction tests were performed in organ baths. At the beginning of each experiment, 80 mM KCl was added to the isolated organ bath with no significant difference among all four groups (p>0.05). Carbachol was then added to the organ bath and contraction responses were obtained. Carbachol contraction responses were calculated as the percentage of the 80 mM KCl contraction responses, with compression groups showing significant difference from control and sham-operated groups (p<0.05). Electrical field stimulation responses were obtained for all group preparations at 4, 8, 16, 32 Hz frequencies, and showed significant difference in the 15 and 60-second compression groups (p<0.05). The contractility was assessed using E-max and pD2 values. All groups exhibited same pD2 values. The study demonstrated a slightly better outcome for bladder contractility with early decompression. However, there was no significant difference between early and delayed decompression groups.Eklem hastalıkları ve cerrahisi = Joint diseases & related surgery. 08/2010; 21(2):110-5. -
Article: CD44 and Ki67 expression in gastric adenocarcinomas (correlation with clinicopathologic parameters)
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ABSTRACT: CD44, a cell adhesion molecule, has been proposed to be important in promoting tumor progression and dissemination. There are many studies about expression of CD44 in many tumors such as gastrointestinal tract, lung, cervix, and liver. Different data have been found about CD44 expression. Ki67 is an indicator that is used to predict the proliferative capacity as well as the prognosis of tumors. The aim of this study was to investigate the expression of CD44 and Ki67 in gastric carcinoma and their relationship between clinicopathologic parameters such as grade, depth of invasion, lymph node metastases and vascular invasion. Immunohistochemical study for CD44 was carried out in 48 formaldehyde fixed, paraffin embedded sections of gastric carcinoma. The results showed that, CD44 and Ki67 did not correlate with the clinicopathologic parameters except grade. High levels of CD44 and Ki67 expressions observed with higher grades. It is concluded that CD44 and Ki67 may be related with the differentiation of gastric carcinoma however they are not correlated with the tumor progression and dissemination. However further studies are required to understand the role of CD44 in metastases and progression of gastric carcinoma.Türk Patoloji Dergisi. 01/2006; -
Article: Subcutaneous undifferentiated sarcoma induced by N'-ethyl-N'-nitrosourea in rat: radiology, histopathology and mutagenesis.
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ABSTRACT: The aim of the present study was to investigate high dose and long-term effects of a common industrial agent, N'-ethyl-N'-nitrosourea (ENU), on soft tissues in a rat model. ENU, which was dissolved in polyethyleneglycol (PEG) was injected intra-peritoneally once a week (300 mg/kg) in the first experimental group. The second group received only PEG. The control group was free of any agent administration. Only rats treated with ENU for a period of 45 weeks developed large subcutaneous tumours (approximately 5-9 cm in size). Tumoral tissues were examined radiologically, histopathologically and immunohistochemically. There was no bone destruction beneath the soft tumoral tissues in direct X radiograms. Computed tomographic (CT) images showed heterogeneous soft tissue masses with a density ranging from 50 to 65 HU. Macroscopically, all tumors were circumscribed with a gray-white surface in the cross-sections. The histopathological and immunohistochemical examination of the subcutaneous tumoral tissues showed a spindle cell type of sarcoma. Lymphatic and skeletal muscle invasion, atypical mitoses and necroses were determined in all tumoral tissues in the experimental group. A somatic point mutation was detected in exon 2 of KRAS oncogene in sarcoma tissues using the single strand conformational polymorphism (SSCP) analysis. In conclusion, the activated KRAS oncogene might contribute to the progression of subcutaneous sarcoma in experimentally ENU induced rats due to point mutation.Experimental and Toxicologic Pathology 12/2003; 55(4):295-300. · 2.78 Impact Factor -
Article: The effects of hemodialysis on duodenal and gastric mucosal changes in uremic patients.
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ABSTRACT: From March 1992 to July 1992, 30 uremic patients (15 dialysed, 15 non-dialysed) and 15 non-uremic patients who had dyspeptic complaints were compared in terms of gastric and duodenal diseases. Gastritis and duodenitis graded as I, II and III were not found different in three groups (p > 0.05). Although the incidence of peptic ulcer disease is very high in both groups of uremic patients in comparison with the controls, there was no significant difference between two uremic groups (p > 0.05). Also the prevalence of gastritis determined histologically was not different in dialysed and non-dialysed uremic patients (p > 0.05). The incidence of the histologically proven gastritis was found higher in uremic patients than in non-uremic patients (p < 0.05). But, there were no significant differences among the three groups with regard to the rate of histologically proved duodenitis (p > 0.05). Gastrin levels, urea positivity, the incidence of gastritis and duodenitis and peptic ulcers did not differ in both uremic groups. However, these values were found significantly high in the uremic patients when compared to non-uremics. These findings showed serum gastrin levels, H.-pylori-infection, gastritis and duodenal disease in the uremic patients to be higher than those of the control group. Moreover, no effect of hemodialysis treatment on these results was observed.Clinical nephrology 05/1996; 45(5):310-4. · 1.17 Impact Factor
