Questions and Answers (5) View all
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Question asked in Carboxylic Acids15 How can we replace the chlorine atom in 3-chloro-2-carboxylic pyridine with free hydrazine hydrate group?First, I tried to reflux equimolar from hydrazine hydrate and 3-chloro-2-carboxylic pyridine in ethanol for 24 hrs. Second, I used hydrazine hydrate a... [more]
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Question asked in Chemical AnalysisOpen How can we replace the chlorine atom in 3-chloro-2-carboxyl pyridine with a free hydrazine hydrate group?First, I tried to reflux equimolor quantities from both reagents in ethanol for 24 hrs. Second, I used hydrazine hydrate as a solvent and refluxed for... [more]
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Answer added in Organic Chemistry140 How could I dry dichloromethane?I usually dry DCM by distillation it with Calicum chloride.
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Answer added in Organic Chemistry48 How ortho and para isomers of benzene derivatives differentiated?the simple method to distingushed such isomers using NMR spectra TOCSY, NOESYCOSY, and J coupling contant gives different values for para and orth... [more]
Publications (24) View all
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Article: Cytotoxicity and Anti-Inflammatory Activity of Methylsulfanyl-triazoloquinazolines.
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ABSTRACT: A series of twenty five 2-methylsulfanyl-[1,2,4]triazolo[1,5-a]quinazoline derivatives 1-25 was previously synthesized. We have now investigated their cytotoxic effects against hepatocellular Hep-G2 and colon HCT-116 carcinoma cells and effect on the macrophage growth, in addition to their influence of the inflammatory mediators [nitric oxide (NO), tumor necrosis factor-α (TNF-α), prostaglandin E-2 (PGE-2) and in bacterial lipopolysachharide (LPS)-stimulated macrophages]. The findings revealed that compounds 13 and 17 showed the highest cytotoxicity and that 3, 6-8 and 25 are promising multi-potent anti-inflammatory agents.Molecules 01/2013; 18(2):1434-46. · 2.39 Impact Factor -
Article: 3-Benzyl-8-meth-oxy-2-sulfanyl-idene-1,2,3,4-tetra-hydro-quinazolin-4-one.
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ABSTRACT: The tetra-hydro-quinazole fused-ring system of the title compound, C(16)H(14)N(2)O(2)S, is roughly planar (r.m.s. deviation = 0.039 Å); the phenyl ring of the benzyl substituent is aligned at 78.1 (1)° with respect to the mean plane of the fused-ring system. In the crystal, two mol-ecules are linked by a pair of N-H⋯S hydrogen bonds about a center of inversion, generating a dimer.Acta Crystallographica Section E Structure Reports Online 06/2012; 68(Pt 6):o1807. · 0.35 Impact Factor -
Article: 2-Methyl-sulfanyl-1,2,4-triazolo[1,5-a]quinazolin-5(4H)-one.
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ABSTRACT: The non-H atoms of the title compound, C(10)H(8)N(4)OS, lie approximately in a common plane (r.m.s. deviation = 0.058 Å). In the crystal, two mol-ecules are linked across a center of inversion by a pair of N-H⋯N hydrogen bonds, forming a a dimer.Acta Crystallographica Section E Structure Reports Online 06/2012; 68(Pt 6):o1805. · 0.35 Impact Factor -
Article: 5-Chloro-2-methyl-sulfonyl-1,2,4-triazolo[1,5-a]quinazoline.
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ABSTRACT: The triazoloquinazole fused-ring system of the title compound, C(10)H(7)ClN(4)O(2)S, is essentially planar (r.m.s. deviation = 0.009 Å). In the methyl-sulfonyl substituent, the two S-O bonds are of equal length [1.402 (2) Å]. In the crystal, adjacent mol-ecules inter-act weakly through Cl⋯N contacts [ca 3.197 (2) Å].Acta Crystallographica Section E Structure Reports Online 06/2012; 68(Pt 6):o1809. · 0.35 Impact Factor -
Article: 2-Methyl-sulfonyl-1,2,4-triazolo[1,5-a]quinazolin-5(4H)-one.
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ABSTRACT: The triazoloquinazoline fused-ring system of the title compound, C(10)H(8)N(4)O(3)S, is essentially planar (r.m.s. deviation = 0.027 Å). In the crystal, adjacent mol-ecules are linked by N-H⋯O(sulfon-yl) hydrogen bonds, generating a helical chain running along the b axis.Acta Crystallographica Section E Structure Reports Online 06/2012; 68(Pt 6):o1806. · 0.35 Impact Factor
