R. Edward Hendrick

Publications (150) View all

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  Available from: R. Edward Hendrick

  Article: Breast cancer screening with imaging: recommendations from the Society of Breast Imaging and the ACR on the use of mammography, breast MRI, breast ultrasound, and other technologies for the detection of clinically occult breast cancer.

  Carol H Lee, D David Dershaw, Daniel Kopans, Phil Evans, Barbara Monsees, Debra Monticciolo, R James Brenner, Lawrence Bassett, Wendie Berg, Stephen Feig, Edward Hendrick, Ellen Mendelson, Carl D'Orsi, Edward Sickles, Linda Warren Burhenne
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  ABSTRACT: Screening for breast cancer with mammography has been shown to decrease mortality from breast cancer, and mammography is the mainstay of screening for clinically occult disease. Mammography, however, has well-recognized limitations, and recently, other imaging including ultrasound and magnetic resonance imaging have been used as adjunctive screening tools, mainly for women who may be at increased risk for the development of breast cancer. The Society of Breast Imaging and the Breast Imaging Commission of the ACR are issuing these recommendations to provide guidance to patients and clinicians on the use of imaging to screen for breast cancer. Wherever possible, the recommendations are based on available evidence. Where evidence is lacking, the recommendations are based on consensus opinions of the fellows and executive committee of the Society of Breast Imaging and the members of the Breast Imaging Commission of the ACR.
  Journal of the American College of Radiology: JACR 01/2010; 7(1):18-27.
• Article: Performance comparison of single-view digital breast tomosynthesis plus single-view digital mammography with two-view digital mammography.

  Gisella Gennaro, R Edward Hendrick, Patricia Ruppel, Roberta Chersevani, Cosimo di Maggio, Manuela La Grassa, Luigi Pescarini, Ilaria Polico, Alessandro Proietti, Enrica Baldan, Elisabetta Bezzon, Fabio Pomerri, Pier Carlo Muzzio
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  ABSTRACT: OBJECTIVE: To determine the performance of combined single-view mediolateral oblique (MLO) digital breast tomosynthesis (DBT) plus single-view cranio-caudal (CC) mammography (MX) compared with that of standard two-view digital mammography. METHODS: A multi-reader multi-case (MRMC) receiver-operating characteristic (ROC) study was conducted, involving six breast radiologists. Two hundred fifty patients underwent bilateral MX and DBT imaging. MX and DBT images with the adjunct of the CC-MX view from 469 breasts were evaluated and rated independently by six readers. Differences in mean areas under the ROC curves (AUCs), mean sensitivity and mean specificity were analysed by analysis of variance (ANOVA) to assess clinical performance. RESULTS: The combined technique was found to be non-inferior to standard two-view mammography (MX((CC+MLO))) in mean AUC (difference: +0.021;95 % LCL = -0.011), but was not statistically significant for superiority (P = 0.197). The combined technique had equivalent sensitivity to standard mammography (76.2 % vs. 72.8 %, P = 0.269) and equivalent specificity (84.9 % vs. 83.0 %, P = 0.130). Specificity for benign lesions was significantly higher with the combination of techniques versus mammography (45.6 % vs. 36.8 %, P = 0.002). CONCLUSION: In this enriched study population, the combination of single-view MLO tomosynthesis plus single-view CC mammography was non-inferior to that of standard two-view digital mammography in terms of ROC curve area, sensitivity and specificity. KEY POINTS : • Breast tomosynthesis (DBT) has emerged as a valuable adjunct to mammography (MX). • Combination DBT/MX demonstrated non-inferior clinical performance to standard two-view MX. • Combination DBT/MX was superior to two-view MX in recognising benign lesions. • Combination DBT/MX reduced variability compared with two-view MX.
  European Radiology 09/2012; · 3.22 Impact Factor
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  Available from: R. Edward Hendrick

  Article: Dual-energy contrast-enhanced digital mammography: initial clinical results of a multireader, multicase study.

  Clarisse Dromain, Fabienne Thibault, Felix Diekmann, Eva M Fallenberg, Roberta A Jong, Marcia Koomen, R Edward Hendrick, Anne Tardivon, Alicia Toledano
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  ABSTRACT: The purpose of this study was to compare the diagnostic accuracy of dual-energy contrast-enhanced digital mammography (CEDM) as an adjunct to mammography (MX) ± ultrasonography (US) with the diagnostic accuracy of MX ± US alone. One hundred ten consenting women with 148 breast lesions (84 malignant, 64 benign) underwent two-view dual-energy CEDM in addition to MX and US using a specially modified digital mammography system (Senographe DS, GE Healthcare). Reference standard was histology for 138 lesions and follow-up for 12 lesions. Six radiologists from 4 institutions interpreted the images using high-resolution softcopy workstations. Confidence of presence (5-point scale), probability of cancer (7-point scale), and BI-RADS scores were evaluated for each finding. Sensitivity, specificity and ROC curve areas were estimated for each reader and overall. Visibility of findings on MX ± CEDM and MX ± US was evaluated with a Likert scale. The average per-lesion sensitivity across all readers was significantly higher for MX ± US ± CEDM than for MX ± US (0.78 vs. 0.71 using BIRADS, p = 0.006). All readers improved their clinical performance and the average area under the ROC curve was significantly superior for MX ± US ± CEDM than for MX ± US ((0.87 vs 0.83, p = 0.045). Finding visibility was similar or better on MX ± CEDM than MX ± US in 80% of cases. Dual-energy contrast-enhanced digital mammography as an adjunct to MX ± US improves diagnostic accuracy compared to MX ± US alone. Addition of iodinated contrast agent to MX facilitates the visualization of breast lesions.
  Breast cancer research: BCR 06/2012; 14(3):R94. · 5.24 Impact Factor
• Article: Breast imaging using an amorphous silicon-based full-field digital mammographic system: Stability of a clinical prototype

  Srinivasan Vedantham, Andrew Karellas, Sankararaman Suryanarayanan, Carl J. D’Orsi, R. Edward Hendrick
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  ABSTRACT: An amorphous silicon-based full-breast imager for digital mammography was evaluated for detector stability over a period of 1 year. This imager uses a structured Csl:Tl scintillator coupled to an amorphous silicon layer with a 100-micron pixel pitch and read out by special purpose electronics. The stability of the system was characterized using the following quantifiable metrics: conversion factor (mean number of electrons generated per incident x-ray), presampling modulation transfer function (MTF), detector linearity and sensitivity, defector signal-to-noise ratio (SNR), and American College of Radiology (ACR) accreditation phantom scores. Qualitative metrics such as flat field uniformity, geometric distortion, and Society of Motion Picture and Television Engineers (SMPTE) test pattern image quality were also used to study the stability of the system. Observations made over this 1-year period indicated that the maximum variation from the average of the measurements were less than 0.5% for conversion factor, 3% for presampling MTF over all spatial frequencies, 5% for signal response, linearity and sensitivity, 12% for SNR over seven locations for all 3 target-filter combinations, and 0% for ACR accreditation phantom scores. ACR mammographic accreditation phantom images indicated the ability to resolve 5 fibers, 4 speck groups, and 5 masses at a mean glandular dose of 1.23 mGy. The SMPTE pattern image quality test for the display monitors used for image viewing indicated ability to discern all contrast steps and ability to distinguish line-pair images at the center and corners of the image. No bleeding effects were observed in the image. Flat field uniformity for all 3 target-filter combinations displayed no artifacts such as gridlines, bad detector rows or columns, horizontal or vertical streaks, or bad pixels. Wire mesh screen images indicated uniform resolution and no geometric distortion.
  Journal of Digital Imaging 04/2012; 13(4):191-199. · 1.25 Impact Factor
• Article: Mammography and the risk of thyroid cancer.

  Ioannis Sechopoulos, R Edward Hendrick
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  ABSTRACT: OBJECTIVE: The purpose of this article is to discuss recent media reports that have suggested a link between mammography and increased incidence of thyroid cancer in women. Those reports have caused many requests that a thyroid shield be used during mammography. CONCLUSION: On the basis of a previously published study that investigated organ doses from mammography and of cancer risk estimates using the seventh Biologic Effects of Ionizing Radiation report, we contend that thyroid shielding during mammography is unnecessary and may increase retakes rather than afford radiation protection of the thyroid.
  American Journal of Roentgenology 03/2012; 198(3):705-7. · 2.78 Impact Factor