Praveen Kumar Vemuri

Publications (10) View all

• Article: Attenuation of Non-enzymatic Thermal Glycation of Bovine Serum Albumin (BSA) using β-Carotene.

  Vijaya Lakshmi Bodiga, Sasidhar Reddy Eda, Vijaya Durga Veduruvalasa, Lalitha Devi Mididodla, Prabhu Kumar Parise, Sujitha Kodamanchili, Swetha Jallepalli, Santhi Priya Inapurapu, Manjusha Neerukonda, Praveen Kumar Vemuri, Sreedhar Bodiga
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  ABSTRACT: Although heat treatment of proteins is believed to promote and accelerate glycation, the accompanying structural changes in proteins because of heat denaturation and/or glycation are not completely understood. In addition, there is an increasing interest for inhibitors of thermal glycation in food processing. β-carotene is a naturally occurring carotenoid found in many vegetables, fruits and herbs, with known antioxidant activity. However, it has not been identified if β-carotene possesses anti-glycation activity. We have tested the anti-glycation capacity of β-carotene in the bovine serum albumin (BSA)/glucose system that was heated to 55 and 65°C for 3 days and studied the level of glycation, conformational alterations in BSA, and changes in hydrophobicity, due to thermal treatment and/or glycation. β-carotene exhibited significant inhibitory effects on the formation of advanced glycation end products (AGEs) and also prevented the secondary structural changes in BSA due to thermal glycation. Our results represent the anti-glycative properties of β-carotene in food systems where such thermal conditions prevail.
  International journal of biological macromolecules 02/2013; · 2.37 Impact Factor
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  Article: Purification and characterization of alkaline phosphatase from Dolichos lab-lab and its invitro dephosphorylation activity on nucleic acids

  Praveen Kumar Vemuri, Krishna Rama Yadam, Naga Sravani Jandhyala, Sreelekha Revur, Ramya Priya Hari Velampati, Anusha Kalapala
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  ABSTRACT: Phosphatase serves several functions in plant metabolism including growth governance, phosphorous level control, starch breakdown etc. Alkaline phosphatases, acting at an alkaline pH 8, are a significant class of enzymes that catalyze release of phosphate esters especially. This enzyme study is so far limited only to animal source and partly to microbial sources, in terms of clinical research. Although it has been identified that plant as a source of this enzyme may be exploited, there always has been a challenge on the isolation and characterization of this enzyme and how pure it can be. This paper partly addresses the above problem, where the enzyme has been isolated from the seeds Dolichos lab-lab plant characterized and its purity was checked by HPLC. The purity obtained was 98% and the enzyme has been further analyzed for its activity on nucleic acids, which gave promising and positive results.
  Journal of Pharmaceutical Sciences and Research 09/2012; 9:3309-3313.
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  Article: Cancer Immune System: A focus on clinical trails of Cancer Vaccines

  Vemuri Praveen Kumar, Raavi Chakrapani, Mummalaneni Krishna Prasad
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  ABSTRACT: Cancer became a big question for scientific community as no existing treatments could solve the problems related to this dreadful disease. Research is in well progress since half century but it failed to give a right solution to fight against it. However the developments in science and technology facilitated scientists to develop new methods of treatment. One such mile stone treatment for cancer that is giving good hope to the people is cancer vaccines. The aim of cancer vaccines is to stimulate the immune system to be able to recognise cancer cells as abnormal and destroy them. Majorly, cancer vaccine research is in progress to develop universal as well as specific cancer vaccines. In the present paper the developments in cancer thearapy especially by empahising vaccine development against cancer was discussed.
  Journal of pure and applied microbiology. 01/2011; 5:Page No. 441-444.
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  Article: Cytokine therapy: clinical and progressive status in cancer

  Vemuri Praveen Kumar, Mamidi Sai Ratna Mounica, Tadikamalla N.L. Swetha, Gogineni V.S.N. Lakshmi, Tullimilli Anusri, Pemmaraju Lakshmi Amulya, Anne Sirisha
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  ABSTRACT: Immunologic approaches to cancer therapy rely on two distinct capabilities of the immune system: targeting the tumour microenvironment by recognising molecules expressed to a greater extent on tumour cells than normal cells and generating immune responses that can kill tumour cells. Immunocytokines, which are fusion proteins composed of a recombinant monoclonal antibody and a cytokine, capitalise on both of these capabilities by combining the ability of tumour-specific antibodies selectively to target tumours with the broad-based immunomodulatory activities of cytokines. This review hypothesises the rationale for development of immunocytokines for cancer and discusses preclinical and clinical data on specific immunocytokines being investigated as potential cancer therapies.
  International Journal of Immunological Studies 01/2011; 1:264 - 271.
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  Article: Probiotics in Improving the Standards of Human Life

  Vemuri Praveen Kumar, Sunkara Prasanthi, Atluri Rohini, Kolli Sarada Gandhi, Arvapalli Durga Manjari
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  ABSTRACT: The term probiotic generally used to describe the living beneficial bacteria that support digestion as well as vaginal and urinary tract health. The good friendly bacteria or probiotics promote the body's natural immunity and keep us healthy. They are very necessary and may keep the bad bacteria level lower. Our gastrointestinal tract is home to more than 400 different species of bacteria weighing one and a half kilograms. This is a large quantity of working bacteria, which perform very important functions in our body - from the mouth all the way down to the rectum. We live in harmony with them and they provide us with an excellent service if they are given a reasonable diet and kept in good health. These probiotics by their beneficiary functions improve the life standards of human being. These probiotics were well exploited in food, medical and aquaculture industries. In the present review we discussed about the functionality and applications of probiotics in various fields.
  Developmental Microbiology and Molecular Biology. 01/2010; 1(1):121-127.