Publications (26) View all
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Article: Nuclear karyopherin a2: a novel biomarker for infiltrative astrocytomas.
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ABSTRACT: The karyopherin (KPNA) protein family is involved in nucleocytoplasmic trafficking. Increased KPNA levels have been found to predict poor prognosis for a variety of solid tumors, including breast, ovarian, cervical, and prostate cancer, and melanoma. The purpose of this study was to evaluate karyopherin a2 as novel biomarker for astrocytic gliomas of WHO grades II-IV. We semiquantitatively measured nuclear expression of karyopherin a2 and the MIB1 labeling index, by immunohistochemical analysis, for 94 primary (23 astrocytomas WHO grade II, 24 astrocytomas WHO grade III, 47 glioblastomas) and 12 recurrent gliomas. In addition, IDH1 mutation status and Nijmegen breakage syndrome 1 protein expression were assessed, by immunohistochemical analysis, for all 71 malignant (WHO grade III and IV) and all 94 primary gliomas, respectively. Statistical analysis was performed by use of standard techniques. Karyopherin a2 expression correlated significantly with histological grade (p < 0.001), with proliferative activity as assessed by the MIB1 index (p < 0.001), with IDH1 mutation status (p = 0.032), and with Nijmegen breakage syndrome 1 protein expression (p = 0.001). Recurrent tumors expressed significantly higher levels of karyopherin a2 (p = 0.045) than primary growths. Multivariate analysis of the overall series identified low karyopherin a2 expression (defined as less than 5 %) as an independent prognostic predictor of overall (p = 0.041) and progression-free survival (p = 0.004). Survival of glioblastoma patients >5 years was seen only in those with KPNA2 expression levels ≤1 % (p = 0.014). KPNA2 expression may have potential as a novel diagnostic and prognostic biomarker for astrocytic gliomas.Journal of Neuro-Oncology 07/2012; 109(3):545-53. · 3.21 Impact Factor -
Article: Zerebrales Aneurysma bei einem 10-jährigen Mädchen
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ABSTRACT: Ursache für eine Subarachnoidalblutung (SAB) sind meist Rupturen angeborener und degenerativ veränderter Aneurysmen der Hirnbasisarterien. Der Altersgipfel der SAB liegt um das 50.Lebensjahr. Eine unerwartete SAB im Kindesalter kann diagnostische Probleme bereiten. Es wird von einem 10-jährigen Mädchen berichtet, das bei starken Nackenschmerzen und Erbrechen ohne Meningismuszeichen nach ärztlicher Untersuchung zu Hause verstarb. Bei der rechtsmedizinischen Sektion fand sich ein großes Aneurysma der rechtsseitigen A.cerebri posterior mit intrazerebraler Wühlblutung und Einbruch in das Ventrikelsystem. Die nur gering ausgeprägte SAB-Ansammlung könnte die fehlenden Meningismuszeichen erklären. Nur 1–2% aller symptomatischen intrazerebralen Aneurysmata betreffen Patienten unter 18Jahren; hierbei ist die A.cerebri posterior häufig (48%) betroffen. Subarachnoid hemorrhages are usually caused by congenital or degenerative aneurysms of the circulus arteriosus cerebri. Subarachnoid hemorrhaging reaches a peak at the age of 50 so that an unexpected subarachnoid hemorrhage in childhood can cause diagnostic problems. The case of a 10-year-old girl who died after a medical examination for severe headache and vomiting without signs of irritation of the meninges (meningism) is reported. The forensic autopsy revealed a giant aneurysm of the posterior cerebral artery with intracerebral haemorrhaging and infiltration of the ventricular system. The lacking signs of meningism could be explained by the weakly expressed subarachnoid haemorrhage. Only 1–2% of all symptomatic intracerebral aneurysms occur in patients under 18 years and the posterior cerebral artery is commonly affected (48%). SchlüsselworteKinder-Subarachnoidale Blutung-Zerebrale Aneurysmen KeywordsCerebral aneurysms-Children-Subarachnoid hemorrhageRechtsmedizin 04/2012; 20(6):504-509. · 0.81 Impact Factor -
Article: Choroid Plexus Adenoma of the Fourth Ventricle
Clinical Neuroradiology 04/2012; 20(2):113-115. · 1.09 Impact Factor -
Article: Non-enhancing primary CNS lymphoma.
Journal of Neuro-Oncology 01/2011; 101(2):343-4. · 3.21 Impact Factor -
Article: Choroid plexus adenoma of the fourth ventricle. High-resolution MRI.
Clinical neuroradiology. 06/2010; 20(2):113-5.
