Ozlem Taskapilioglu

Publications (25) View all

• Article: Shape analysis of the corpus callosum and cerebellum in female MS patients with different clinical phenotypes.

  Deniz Sigirli, Ilker Ercan, Senem Turan Ozdemir, Ozlem Taskapilioglu, Bahattin Hakyemez, Omer Faruk Turan
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  ABSTRACT: The aim of this study was to investigate the shape differences in the corpus callosum (CC) and cerebellum of female relapsing-remitting multiple sclerosis (RRMS) and secondary progressive multiple sclerosis (SPMS) patients compared with healthy controls. This study was conducted using the magnetic resonance imaging scans of 15 control subjects, 26 RRMS, and 14 SPMS patients. The data obtained from the landmark coordinates were analyzed with statistical shape analysis. The landmarks that were chosen to determine the shape differences of the CC and cerebellum have been identified and used in previous studies. In addition to these landmarks, constructed landmarks were determined and used to assess regional shape differences better. The shapes of the CC and cerebellum showed statistically significant differences from the controls when compared with both the RRMS and SPMS patients. It was found that the deformation observed from controls to SPMS was greater than the deformation from controls to RRMS, both for the CC and cerebellum. In conclusion, this study revealed CC and cerebellar shape change in RRMS and SPMS, and showed that deformations both in CC and cerebellum advances with the disease progression.
  The Anatomical Record Advances in Integrative Anatomy and Evolutionary Biology 05/2012; 295(7):1202-11. · 1.47 Impact Factor
• Article: Erratum to: Structural and neurochemical evaluation of the brain and pons in patients with Wilson’s disease

  Oktay Algin, Ozlem Taskapilioglu, Bahattin Hakyemez, Gokhan Ocakoglu, Sukran Yurtogullari, Sevda Erer, Mufit Parlak
  Japanese journal of radiology 05/2012; 29(1):83-83. · 0.65 Impact Factor
• Article: Structural and neurochemical evaluation of the brain and pons in patients with Wilson’s disease

  Oktay Algin, Ozlem Taskapilioglu, Bahattin Hakyemez, Gokhan Ocakoglu, Sukran Yurtogullari, Sevda Erer, Mufit Parlak
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  ABSTRACT: PurposeThe aim of this study was to examine the structural-neurochemical abnormalities of the frontal white matter (FWM), deep gray matter nuclei, and pons in patients with Wilson’s disease (WD) using proton magnetic resonance spectroscopy (MRS) and diffusion-weighted imaging (DWI). Materials and methodsNine patients with WD and 14 age-matched controls were examined with MRS. N-Acetylaspartate (NAA), choline (Cho), and creatine (Cr) peaks were calculated. DWI scans from six WD patients and six controls were also obtained. The relative metabolite ratios and apparent diffusion coefficient (ADC) values of the WD patients were compared to those of the control subjects by using statistical measures. ResultsMeasurements in the thalamus and pons showed significantly lower NAA/Cho and NAA/Cr ratios in the WD group than in the control group (P < 0.05). Thalamic and pontine Cho/Cr ratios in the patient group were significantly higher than those of the control group (P < 0.05). No statistically significant relation was found between the patient and control groups as a result of the MRS examinations of FWM and all ADC measurements (P > 0.05). ConclusionMRS is a noninvasive, valuable modality for detecting structural-neurochemical changes of the brain stem and deep gray matter in patients with WD. The contribution of DWI in these patients is limited. Key wordsWilson’s disease-Proton MR spectroscopy-Neuroimaging-Diffusion magnetic resonance imaging-Neuronal loss
  Japanese journal of radiology 04/2012; 28(9):663-671. · 0.65 Impact Factor
• Article: Sociodemographics, clinical features, and psychiatric comorbidities of patients with psychogenic nonepileptic seizures: experience at a specialized epilepsy center in Turkey.

  Ibrahim Hakki Bora, Ozlem Taskapilioglu, Meral Seferoglu, Ozan Vahap Kotan, Aylin Bican, Guven Ozkaya, Cengiz Akkaya
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  ABSTRACT: Patients with psychogenic nonepileptic seizures (PNESs) or pseudoseizures are known to have psychiatric comorbidities. In the present retrospective analysis, we examined the sociodemographics, clinical characteristics, and psychiatric diagnoses of patients with PNESs. Our aim is to demonstrate the contribution of the consulting psychiatrists to the presumed psychiatric diagnoses of the neurologists. We used data from long-term video EEG monitoring (LVEM) performed at a specialized epilepsy center in Turkey. The study group comprised 67 patients (mean age: 30 years, 75% female) diagnosed with PNESs following LVEM of approximately 5 days' duration. Two hundred thirty-three episodes were recorded. Most of the patients experienced a PNES on the first day. All of the patients were taking antiepileptic drugs (AEDs) at the time of admission; 56.7% were taking antidepressant (AD) drugs. All of the PNES patients were diagnosed with conversion disorder by both the neurologists and the psychiatrists. Most of the PNES patients were using multiple AEDs. Cooperation between neurologists and psychiatrists and ongoing education for both neurologists and psychiatrists about PNES are needed in appropriate diagnosing and management of patients with PNES.
  Seizure 03/2011; 20(6):458-61. · 1.80 Impact Factor
• Article: Neurochemical-structural changes evaluation of brain in patients with obstructive sleep apnea syndrome.

  Oktay Algin, Gokhan Gokalp, Gokhan Ocakoglu, Ahmet Ursavas, Ozlem Taskapilioglu, Bahattin Hakyemez
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  ABSTRACT: To evaluate neurochemical and structural changes in the patients with newly diagnosed obstructive sleep apnea syndrome (OSAS) by MR spectroscopy (MRS), T2 relaxometry, and diffusion weighted imaging (DWI). Following the acquisition of routine cranial MR, MRS, T2 relaxometry, and DWI images; spectroscopic metabolite ratios and DWI-T2 relaxometry findings of the thalami, hippocampi, frontal white matter (FWM) and frontal cortex of 24 OSAS patients and 9 controls were statistically compared. The relationship between two groups was evaluated with Mann-Whitney test. Spectroscopic measurements in the frontal cortex and frontal white matter of the OSAS patients revealed significantly lower NAA/Cr ratios than those of the control group (P=0.004 and P=0.006, respectively). The measurements in the frontal white matter of the OSAS patients exhibited significantly lower NAA/Cho ratios compared with those of the control group (P=0.005). Thalamic Cho/Cr ratios of the patient group were significantly higher than those of the control group (P=0.002). In terms of the ADC-T2 relaxometry values, there was no significant relationship between the patient and the control groups (P>0.05). MRS is a useful and non-invasive modality in showing neurochemical changes in various regions of the brain but our data does not show any change on diffusion weighting or T2 quantification in the OSAS group. DWI and T2 relaxometry appear to be not effective techniques to evaluate the brain structural changes of the patients with newly diagnosed OSAS.
  European journal of radiology 02/2011; 81(3):491-5. · 2.65 Impact Factor