Publications (215) View all
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Article: Prospective assessment of incidence of Tako-Tsubo cardiomyopathy in a very large urban agglomeration.
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ABSTRACT: BACKGROUND: Tako-Tsubo cardiomyopathy (TTC) is a recently described medical entity and the incidence of TTC in a global population is still uncertain. We sought to prospectively assess the incidence of TTC in a large urban area. METHODS AND RESULTS: We included all consecutive patients referred for coronary angiography in three hospitals located in Paris and its suburbs. We prospectively estimated the percentage of TTC among patients referred for coronary angiography and extrapolated the number of cases of TTC in the greater Paris area (11,598,866 inhabitants) according to the CARDIO-ARHIF registry (government agency). Among 2547 patients (2972 coronary angiographies) including 815 acute coronary syndromes, 20 patients presented with TTC (19 women, mean age 66±13years). The percentage of TTC among suspected acute coronary syndromes was 2.5% (8.2% in women versus 0.2% in men, p<0.001). In the CARDIO-ARHIF registry, we individualized 51,403 coronary angiographies performed in all catheterization laboratories in one year (13,820 women and 10,246 women ≥60years). In this region, the yearly number of TTC cases is estimated to be 346 (95% CI: 216-520). The annual incidence of TTC is estimated to be 29.8 per 1,000,000 inhabitants (95% CI: 18.6-44.9), 48.2 per 1,000,000 inhabitants (95% CI: 29.7-73.0) among women and 187.4 per 1,000,000 inhabitants (95% CI: 103.3-307.2) among women ≥60years. CONCLUSIONS: Within a large urban agglomeration, the incidence of TTC is high in women ≥60years. The current rate of this recently described cardiomyopathy has been underestimated in previous retrospective studies and will probably rise with the increase of life expectancy.International journal of cardiology 04/2013; · 7.08 Impact Factor -
Article: [Tako-Tsubo cardiomyopathy.]
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ABSTRACT: Tako-Tsubo cardiomyopathy usually mimics an acute coronary syndrome and is defined as a transient left ventricular systolic dysfunction. Stress is frequently present, but is not systematically found. Diagnosis is based on the criteria of the Mayo-Clinic. Tako-Tsubo cardiomyopathy preferentially affects postmenopausal women. Several explorations are performed to confirm the diagnosis: electrocardiogram, biomarkers, echocardiography, coronary angiography and left ventricular angiography, and MRI. Left ventricular dysfunction is pathognomonic, with circular akinesia regarding the different mid and apical segments of the left ventricle in its typical form. Complications may occur in the acute phase and should be systematically assessed. The complete recovery of left ventricular systolic dysfunction is the rule and must be assessed, allowing to confirm the diagnosis of Tako-Tsubo cardiomyopathy.La Presse Médicale 04/2013; · 0.67 Impact Factor -
Dataset: Friedrich et al. - A novel genetic variant in the transcription factor Islet-1 exerts gain of function on myocyte enhancer factor 2C promoter activity - 2012
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Article: A novel genetic variant in the transcription factor Islet-1 exerts gain of function on myocyte enhancer factor 2C promoter activity.
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ABSTRACT: AIMS: The transcription factor Islet-1 (ISL1) is a marker of cardiovascular progenitors and is essential for mammalian cardiogenesis. An ISL1 haplotype has recently been associated with congenital heart disease. In this study we evaluated whether ISL1 variants are associated with hypertrophic (HCM), dilated (DCM), arrhythmogenic right ventricular cardiomyopathy (ARVC), or with Emery-Dreifuss muscular dystrophy (EDMD). METHODS AND RESULTS: The six exon and intron boundaries of ISL1 were screened for genetic variants in a cohort of 454 index cases. Eleven exonic variants were identified in HCM, DCM, ARVC, and/or EDMD. Out of the five novel variants, two are located in the 5'-untranslated region, two are silent (p.Arg171Arg and p.Asn189Asn), and one is a missense (p.Asn252Ser). The latter was identified in the homozygous state in one DCM patient, and in the heterozygous state in 11 relatives, who did not present with DCM but often with cardiovascular features. This variant was found in one HCM patient also carrying a MYH7 mutation and in 3/96 North-African Caucasian control individuals, but was absent in 138 European Caucasian control individuals. We investigated the effect of the ISL1 wild type and p.Asn252Ser mutant on myocyte enhancer factor 2C (Mef2c) promoter activity, an established ISL1 target. Mef2c promoter activity was ∼4-fold higher in the presence of wild-type and ∼6-fold higher in the presence of mutant ISL1 in both HEK and CHO cells. CONCLUSION: This study describes a new gain-of-function p.Asn252Ser variant in the human ISL1 gene, which could potentially lead to greater activation of downstream targets involved in cardiac development, dilation, and hypertrophy.European Journal of Heart Failure 11/2012; · 4.90 Impact Factor -
Article: Diagnosis of saphenous coronary graft aneurysm by spiral computed tomography
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ABSTRACT: We report two cases of coronary saphenous vein graft aneurysms diagnosed by spiral computed tomography.CardioVascular and Interventional Radiology 04/2012; 23(2):142-144. · 2.09 Impact Factor
