Nathalie Dantan

Publications (8) View all

• Article: Flow injection analysis coupled with HPLC and CE for monitoring chemical production processes

  N. Dantan, W. Frenzel, S. Küppers
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  ABSTRACT: In chemical and pharmaceutical production plants process control is often performed by plant personal near the process (at-line). Alternatively, spectroscopic procedures like near infrared may be coupled to the process using in-line or on-line interfaces. When the analytical problem cannot be solved by these established approaches chromatographic techniques can be directly coupled to the production process. An application of chemical reaction monitoring which is difficult to perform is reported. The analytical problems are solved by HPLC and CE. Both techniques in the application presented need an on-line derivatization step prior to the analysis. Flow Injection Analysis (FIA) was applied for this sample preparation step. For the online coupling to the commercially available CE-instrument a special sample vial was developed. The application shows sufficient reproducibility and analysis speed for near real-time monitoring. of the process.
  Chromatographia 07/2001; 54(3):187-190. · 1.20 Impact Factor
• Article: Hyphenation of Flow Injection Analysis with HPLC and CE for monitoring of chemical production processes

  N. Dantan, W. Frenzel, S. Küppers
  Chromatographia 01/2001; 54:187-90. · 1.20 Impact Factor
• Article: Determination of water traces in various organic solvents using Karl Fischer method under FIA conditions.

  N Dantan, W Frenzel, S Küppers
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  ABSTRACT: Flow injection methods utilising the Karl Fischer (KF) reaction with spectrophotometric and potentiometric detection are described for the determination of the trace water content in various organic solvents. Optimisation of the methods resulted in an accessible (linear) working range of 0.01-0.2% water for many solvents studied with a typical precision of 1-2% R.S.D. Only 50 mul of organic solvent was injected and the sampling frequency was about 120 samples per h. Since the slopes of the calibration curves were different for different solvents appropriate calibration was required. Problems associated with spectrophotometric detection and caused by refractive index changes were pointed out and a nested-loop configuration was proposed to overcome this kind of interference. The potentiometric method with a novel flow-through detector cell was shown to surpass the performance of spectrophotometric detection in any respect. The characteristics of the procedures developed made them well applicable for on-line monitoring of technical solvent distillations in an industrial plant.
  Talanta 06/2000; 52(1):101-9. · 3.79 Impact Factor
• Article: Comparison of spectrophotometric and potentiometric detection for the determination of water using Karl Fischer method under FIA conditions

  N. Dantan, S. Kröning, W. Frenzel, S. Küppers
  Analytica Chimica Acta 01/2000; 420:133-142. · 4.55 Impact Factor
• Article: Chemometrie in der industriellen Analytik

  Nathalie Dantan, Stephan Küppers
  Nachrichten aus der Chemie 04/2010; 49(7‐8):917 - 921. · 0.19 Impact Factor