35 Questions8148 Followers
202 Questions18892 Followers
Answer added in Pharmaceutical Development30 Can we use expired drugs? Besides reduced efficacy are there any major side effects associated with expired products?By Veemala Coolen · University of MauritiusI think that some expired drugs can be used when their validity can be confirmed through quality control (physical and chemical) analyses especially ... [more]I think that some expired drugs can be used when their validity can be confirmed through quality control (physical and chemical) analyses especially for those dosage forms that are stated in the official monographs like BP & USP especially when the tests for degradation products, if available (or related compound as stated in the monographs) are still within the acceptable limits. also when the tests for the performance of the dosage form (like dissolution test) are also within acceptable limits especially when these medications are stored properly. I don not mean that we should accept the idea of using the expired medications instead of disposing them, but sometimes it might be necessary to consider some preparations that might be expensive or rare in some countries or in some widespread epidemics or war time when other choices are not easily or rapidly available.Following
Answer added in Pharmaceutics Formulation3 Cause of fine precipitate formation in liquid oral dosage formsBy Nashwan Yousif ·thank you Hinal for your answer, the solutions I mean are the single phase clear solutions that develop such problems. also it is not a matter of solu... [more]thank you Hinal for your answer, the solutions I mean are the single phase clear solutions that develop such problems. also it is not a matter of solubility because all the ingredients used are completely soluble in the concentrations used. I need more specific and detailed answers from people experienced in pharmaceutical industry and stability study of oral solutions who might have faced such challenges. Best wishes to youFollowing
Question asked in Pharmaceutics Formulation3 Cause of fine precipitate formation in liquid oral dosage formsCan you explain the cause of fine ppt formation in liquid oral dosage form (other than filtration) that develops on standing for some time (storage) a... [more]Can you explain the cause of fine ppt formation in liquid oral dosage form (other than filtration) that develops on standing for some time (storage) and disappears on mild agitation to form again on standing for a short period. Do you suggest any formulation problems?By Nashwan Yousif ·Following
Answer added in Pharmaceutical5 What's the effect of solid dispersions on first pass metabolism and protein binding ?By Kifayat Ullah Shah · Gomal UniversitySolid dispersion technique is just a method of formulation to enhance solubility of the poorly soluble drugs. first pass metabolism depends on the ch... [more]Solid dispersion technique is just a method of formulation to enhance solubility of the poorly soluble drugs. first pass metabolism depends on the chemical structure of the active drug substance that is administered via oral route, and the formulation has no direct effect on it. Theoretically, since increasing the solubility can increase the fraction of drug absorbed and then the amount of drug delivered through portal vein to the liver, then for a saturable drug metabolizing hepatic enzyme, the amount of free drug that can escape the metabolism can certainly increase and we get higher bioavailability. plasma protein binding, on the other hand, is not affected by solid dispersion as it depends on the drug physico-chemical properties. best regardsFollowing
Answer added in Pharmaceutical3 What are the different solid states of ibuprofen? What's the difference between these states? Which one is on the market?By Sandrella Saad · Lebanese American UniversityThe marketed ibuprofen is usually the racemic mixture as there is no significant difference in activity between the dextro and levo isomers and it wou... [more]The marketed ibuprofen is usually the racemic mixture as there is no significant difference in activity between the dextro and levo isomers and it would be cheaper to use the racemic mixture than any of the separate optically active isomers. Best regardsFollowing
Article: SOLUBILITY AND DISSOLUTION IMPROVEMENT OF KETOPROFEN BY SOLID DISPERSION IN POLYMER AND SURFACTANT USING SOLVENT EVAPORATION METHOD[show abstract] [hide abstract]
ABSTRACT: Ketoprofen is a propionic acid derivative non‐steroidal anti inflammatory drug. It is widely used in the management and treatment of patients with rheumatic disease, but its poor water solubility can give rise to formulation problems and reduce its therapeutic efficiency and bioavailability. The present project was designed to improve solubility and dissolution of ketoprofen. Various solid dispersions formulas of ketoprofen were prepared by solvent evaporation method using mannitol, Urea, PVP K30, and Tween 80 as carriers to enhance solubility of compound. These formulations were evaluated for drug content, phase solubility, and in vitro dissolution. Evaluation by Deferential Scanning Calorimetry (DSC) and Fourier Transformer Infra Red (FTIR) revealed no chemical interaction between the drug and its carriers. All formulas showed marked improvement in solubility behavior and drug release in the following order PVP K‐30> urea>mannitol. Formulation (F12) containing ketoprofen: PVP K‐30: Tween 80 ratio of 1:3:1 showed best release (95.0%) compared to 23.20 % for the pure drug at 5 minutes. In conclusion, solid dispersion of ketoprofen in polymer with surfactant properties (formulation-F12) can be utilized to improve solubility and release of ketoprofen oral solid dosage form.International Journal of Pharmacy and Pharmaceutical Sciences. 01/2011; 3:431-435.
B.Sc in Pharmacy (Baghdad Univ./Baghdad-Iraq) 1992
1- year training course in the field of clinical biochemistry & microbiology laboratories
M.Sc in Pharmaceutics(Baghdad Univ)
worked for 13 years at the National center for drug quality control & research labs
now I am a specialist senior pharmacist at the MOH/Pharmacy dept.