Nashwan Yousif

Questions and Answers (13) View all

• Answer added in Pharmaceutical Development
  30 Can we use expired drugs? Besides reduced efficacy are there any major side effects associated with expired products?
  By Veemala Coolen · University of Mauritius
  Nashwan Yousif ·

  I think that some expired drugs can be used when their validity can be confirmed through quality control (physical and chemical) analyses especially ... [more]

  I think that some expired drugs can be used when their validity can be confirmed through quality control (physical and chemical) analyses especially for those dosage forms that are stated in the official monographs like BP & USP especially when the tests for degradation products, if available (or related compound as stated in the monographs) are still within the acceptable limits. also when the tests for the performance of the dosage form (like dissolution test) are also within acceptable limits especially when these medications are stored properly. I don not mean that we should accept the idea of using the expired medications instead of disposing them, but sometimes it might be necessary to consider some preparations that might be expensive or rare in some countries or in some widespread epidemics or war time when other choices are not easily or rapidly available.
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• Answer added in Pharmaceutics Formulation
  3 Cause of fine precipitate formation in liquid oral dosage forms
  By Nashwan Yousif ·
  Nashwan Yousif ·

  thank you Hinal for your answer, the solutions I mean are the single phase clear solutions that develop such problems. also it is not a matter of solu... [more]

  thank you Hinal for your answer, the solutions I mean are the single phase clear solutions that develop such problems. also it is not a matter of solubility because all the ingredients used are completely soluble in the concentrations used. I need more specific and detailed answers from people experienced in pharmaceutical industry and stability study of oral solutions who might have faced such challenges. Best wishes to you
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• Question asked in Pharmaceutics Formulation
  3 Cause of fine precipitate formation in liquid oral dosage forms
  Can you explain the cause of fine ppt formation in liquid oral dosage form (other than filtration) that develops on standing for some time (storage) a... [more]
  Can you explain the cause of fine ppt formation in liquid oral dosage form (other than filtration) that develops on standing for some time (storage) and disappears on mild agitation to form again on standing for a short period. Do you suggest any formulation problems?
  By Nashwan Yousif ·
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• Answer added in Pharmaceutical
  5 What's the effect of solid dispersions on first pass metabolism and protein binding ?
  By Kifayat Ullah Shah · Gomal University
  Nashwan Yousif ·

  Solid dispersion technique is just a method of formulation to enhance solubility of the poorly soluble drugs. first pass metabolism depends on the ch... [more]

  Solid dispersion technique is just a method of formulation to enhance solubility of the poorly soluble drugs. first pass metabolism depends on the chemical structure of the active drug substance that is administered via oral route, and the formulation has no direct effect on it. Theoretically, since increasing the solubility can increase the fraction of drug absorbed and then the amount of drug delivered through portal vein to the liver, then for a saturable drug metabolizing hepatic enzyme, the amount of free drug that can escape the metabolism can certainly increase and we get higher bioavailability. plasma protein binding, on the other hand, is not affected by solid dispersion as it depends on the drug physico-chemical properties. best regards
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• Answer added in Pharmaceutical
  3 What are the different solid states of ibuprofen? What's the difference between these states? Which one is on the market?
  By Sandrella Saad · Lebanese American University
  Nashwan Yousif ·

  The marketed ibuprofen is usually the racemic mixture as there is no significant difference in activity between the dextro and levo isomers and it wou... [more]

  The marketed ibuprofen is usually the racemic mixture as there is no significant difference in activity between the dextro and levo isomers and it would be cheaper to use the racemic mixture than any of the separate optically active isomers. Best regards
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