Moncef Khairallah

Publications (89) View all

• Article: Parasitic Infections of the External Eye.

  Shivani Pahuja, Charuta Puranik, Bechir Jelliti, Moncef Khairallah, Virender S Sangwan
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  ABSTRACT: Abstract Objective: To review the published literature on parasitic infections of external eye. Methods: Published articles and case reports on parasitic infections of external eye were reviewed and relevant information was collected. Results: Parasitic infections of the eye are rare. However, being more commonly seen in developing nations, they require active measures for screening, diagnosis, and therapy. Parasites of importance causing external ocular disease are protozoan parasites, such as Leishmania; metazoans, such as nematodes (roundworms), cestodes (tapeworms), and trematodes (flatworms); or ectoparasites, such as Phthirus pubis and Demodex.
  Ocular immunology and inflammation 04/2013; · 0.72 Impact Factor
• Article: Branch retinal artery occlusion associated with posterior uveitis.

  Rim Kahloun, Samah Mbarek, Imen Khairallah-Ksiaa, Bechir Jelliti, Salim Ben Yahia, Moncef Khairallah
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  ABSTRACT: The purpose of this study is to report the clinical features and visual outcome of branch retinal artery occlusion (BRAO) associated with posterior uveitis. This is a retrospective study including the 18 eyes of 18 patients. All patients underwent a complete ophthalmic evaluation. Fundus photography, fluorescein angiography, and visual field testing were performed in all cases. Diseases associated with BRAO included active ocular toxoplasmosis in 7 patients, rickettsiosis in 4, Behçet's uveitis in 2, West Nile virus infection in 1, idiopathic retinal vasculitis in 1, Crohn's disease in 1, ocular tuberculosis in 1, and idiopathic retinal vasculitis, aneurysms, and neuroretinitis syndrome in 1 patient. The mean initial visual acuity was 20/50. BRAO involved the first order retinal artery in 33.3% of the eyes, the second order retinal artery in 33.3%, an arteriole in 27.8%, and a cilioretinal artery in 5.5%. The macula was involved in 44.4% of the eyes and an acute focus of retinitis or retinochoroiditis was associated to BRAO in 55.5%. Repermeabilization of the occluded artery occurred in all patients with permanent scotomas in the corresponding visual field. The mean visual acuity at last visit was 20/32. BRAO, with subsequent visual impairment, may occur in the eyes with posterior uveitis. Physicians should be aware of such vision-threatening complication of infectious and inflammatory eye diseases.
  Journal of ophthalmic inflammation and infection. 01/2013; 3(1):16.
• Article: New Infectious Etiologies for Posterior Uveitis.

  Moncef Khairallah, Rim Kahloun, Salim Ben Yahia, Bechir Jelliti, Riadh Messaoud
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  ABSTRACT: Emergent and resurgent arthropod vector-borne diseases are major causes of systemic morbidity and death and expanding worldwide. Among them, viral and bacterial agents including West Nile virus, Dengue fever, Chikungunya, Rift Valley fever, and rickettsioses have been recently associated with an array of ocular manifestations. These include anterior uveitis, retinitis, chorioretinitis, retinal vasculitis and optic nerve involvement. Proper clinical diagnosis of any of these infectious diseases is based on epidemiological data, history, systemic symptoms and signs, and the pattern of ocular involvement. The diagnosis is usually confirmed by the detection of a specific antibody in serum. Ocular involvement associated with emergent infections usually has a self-limited course, but it can result in persistent visual impairment. There is currently no proven specific treatment for arboviral diseases, and therapy is mostly supportive. Vaccination for humans against these viruses is still in the research phase. Doxycycline is the treatment of choice for rickettsial diseases. Prevention, including public measures to reduce the number of mosquitoes and personal protection, remains the mainstay for arthropod vector disease control. Influenza A (H1N1) virus was responsible for a pandemic human influenza in 2009, and was recently associated with various posterior segment changes.
  Ophthalmic Research 12/2012; 49(2):66-72. · 1.56 Impact Factor
• Article: Epidemiology of behçet disease.

  Moncef Khairallah, Massimo Accorinti, Cristina Muccioli, Rim Kahloun, John H Kempen
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  ABSTRACT: Behçet disease (BD) is a multisystem inflammatory disorder that is an important cause of morbidity worldwide. BD is most common along the ancient "Silk Road" route in the Far East and Mediterranean basin. The eye is the most commonly involved organ in BD patients.The prototypical form of involvement is a relapsing remitting panuveitis and retinal vasculitis. Less commonly, BD may present in the form of conjunctivitis, conjunctival ulcers, keratitis, episcleritis, scleritis, and extraocular muscle paralysis. Uveitis in BD carries significant implications for the patient, because it is a chronic recurrent disease characterized by explosive attacks of severe inflammation that may cause significant, cumulative damage to the intraocular structures. This review summarizes the epidemiology of systemic and ocular clinical features of BD with particular focus on risk factors, clinical characteristics, complications, and prognosis of BD-associated uveitis.
  Ocular immunology and inflammation 10/2012; 20(5):324-35. · 0.72 Impact Factor
• Article: Three-year visual and anatomic results of administrating intravitreal bevacizumab in inflammatory ocular neovascularization.

  Ahmad M Mansour, J Fernando Arevalo, Christine Fardeau, Emily N Hrisomalos, Wai-Man Chan, Timothy Y Y Lai, Focke Ziemssen, Thomas Ness, Abla Mehio Sibai, Friederike Mackensen, [......], Yasushi Ikuno, Jad Akesbi, Phuc LeHoang, Alfredo Adan, Padmamalini Mahendradas, Moncef Khairallah, Rainer Guthoff, Blanche Ghandour, Cem Küçükerdönmez, Shree K Kurup
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  ABSTRACT: To assess the 3-year visual outcome of intravitreal bevacizumab in inflammatory ocular neovascularization. Experimental study. Retrospective multicenter consecutive case series in 81 patients with inflammatory ocular neovascularization refractory to standard therapy and treated with intravitreal bevacizumab. The outcome measures included improvement of best corrected visual acuity expressed as logarithm of minimum angle of resolution (logMAR) and paired comparison decrease in central foveal thickness by optical coherence tomography. Mean best corrected visual acuity improved from baseline 0.699 (6/30 or 20/101) (SD 0.434) to 0.426 (6/16 or 20/53) (SD 0.428) (n = 81; p < 0.001), a gain of 2.7 lines (median 3 injections; 81 eyes; 81 patients). Paired comparisons revealed significant central foveal flattening at 3 years of 97.9 μm (n = 51; p < 0.001). In a subgroup analysis, visual improvement was significant for ocular histoplasmosis (p = 0.026); multifocal choroiditis (p = 0.05); serpiginous choroiditis (p = 0.028); ocular toxoplasmosis (p = 0.042); and punctate inner choroidopathy (p = 0.015). In a subgroup analysis, foveal flattening was significant for ocular histoplasmosis (p = 0.004); multifocal choroiditis (p = 0.007); serpiginous choroiditis (p = 0.011); and punctate inner choroidopathy (p = 0.001). Of the group, 5 eyes developed submacular fibrosis, 1 eye retinal pigment epithelial tear, and 1 eye macular ischemia in the context of vasculitis. At 3 years, intravitreal bevacizumab sustained significant visual improvement of 2.7 lines and significant foveal flattening of 98 μm in a wide variety of inflammatory ocular diseases without major complications after a median of 3 injections.
  Canadian Journal of Ophthalmology 06/2012; 47(3):269-74. · 1.47 Impact Factor