Mohammadreza Abbaspour

Publications (14) View all

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  Article: Nanodrugs and Natural Pharmaceutical Products

  Mohammadreza Abbaspour
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  ABSTRACT: Editorial: To consider the application of naturally occurring materials in novel drug delivery systems and advancements of nanotech-nology in formulating natural pharmaceutical products.
  Jundishapur Journal of Natural Pharmaceutical Products. 05/2012;
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  Article: Effect of different molecular weights of chitosan on preparation and characterization of insulin loaded nanoparticles by ion gelation method

  Maryam Kouchak, Mohammadreza Avadi, Mohammadreza Abbaspour, Alireza Jahangiri, Sara Kargar Boldaji
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  ABSTRACT: Nanoparticulate drug delivery systems have several opportunities to overcome bioavailability or stability problems of peptide and protein drugs. In this study a 2 3 full factorial design was used for preparation of insulin containing nanoparticles using different concentrations of low, medium and high molecular weight chitosan (CS) and tripolyphosphate (TPP) by ion gelation method. Encapsulation efficiencies (EE) of each formulation were determined by HPLC method. Regression analysis and surface plots were used in order to evaluating the effect of variables on EE and choosing the optimum formulations. The morphology of selected nanoparticles was obtained by transmission electron microscopy (TEM). Particle size, poly dispersity index (PDI) and zeta potential were also measured. Freeze-dried nanoparticles were used for drug release studies in phosphate buffer (pH=6.8). Resulted nanoparticles had mean size of 112-419 nm with PDI< 0.5 and positive zeta potential. Insulin concentration and molecular weight of chitosan had pronounced effect on EE, but chitosan concentration had no considerable effect on EE. The maximum EE of CS nanoparticles with low, medium and high molecular weights were 61.88 %, 70.89 % and 53.73 %, respectively. The in vitro drug release profiles from the low molecular weight chitosan nanoparticles showed an initial burst release followed by a slow release within 3 hours.
  International Journal of Drug Development and Research. 05/2012;
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  Article: Preparation and evaluation of pellets using acacia and tragacanth by extrusion-spheronization.

  A Akhgari, M R Abbaspour, S Pirmoradi
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  ABSTRACT: BACKGROUND AND THE PURPOSE OF THE STUDY: Extrusion-spheronization is an established technique for the production of pellets for pharmaceutical applications. In this study, the feasibility and influence of the incorporation of acacia, by itself and in combination with tragacanth, on the ability of formulations containing 2 model of drugs (ibuprofen and theophylline) to form spherical pellets by extrusion-spheronization was investigated. Formulations containing different ratios of acacia and tragacanth (8:2, 9:1, and 10:0) and different drug concentrations (20%, 40%, and 60%) were prepared, on the basis of a 3(2) full factorial design. Pellet properties, such as aspect ratio, sphericity (image analysis), crushing strength and elastic modulus (mechanical tests), mean dissolution time, and dissolution profiles were evaluated. The effect of particular factors on responses was determined by linear regression analysis. The sphericity, drug release rate, and the mechanical properties of the pellets were affected by the amounts and types of the drugs, and the ratio of the gums. Acacia, relative to tragacanth, produced pellets with higher mechanical strength and a faster drug release rate. Addition of small amounts of tragacanth to ibuprofen formulations resulted in matrix pellets with slow drug release. The results showed that acacia and tragacanth can be used successfully as 2 natural binders in the pellet formulations.
  Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. 01/2011; 19(6):417-23.
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  Article: Oral nicotinamide reduces serum phosphorus, increases HDL, and induces thrombocytopenia in hemodialysis patients: a double-blind randomized clinical trial.

  Heshmatolah Shahbazian, Azita Zafar Mohtashami, Ali Ghorbani, Mohammad Reza Abbaspour, Sayed Seifolah Belladi Musavi, Fatemeh Hayati, Ghollam Reza Lashkarara
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  ABSTRACT: Recently, nicotinamide has been suggested as an effective drug for hyperphosphatemia in hemodialysis patients. The authors assessed the efficacy and safety of nicotinamide in these patients with lower doses and longer duration than other studies. Forty eight patients with fasting serum phosphorus >5 mg/dl enrolled in this randomized clinical trial study and were randomly assigned to two equal-sized groups of nicotinamide or placebo. The study lasted 8 weeks. In the first four weeks, nicotinamide was administered at 500 mg/day, and in the second four weeks at 1,000 mg/day. Blood samples were tested at baseline, week 4, and week 8. In nicotinamide group, the mean phosphorus level decreased from 5.9 ± 0.58 mg/dl to 4.77 ± 1.43 mg/dl in week 4 (P = 0.002) and to 4.66 ± 1.06 mg/dl in week 8 (P = 0.000). The mean calcium-phosphorus product decreased significantly with the same pattern as phosphorus. High-density lipoprotein level increased from 42.46 ± 8.01 mg/dl to 55.71 ± 11.88 mg/dl in week 4 (P = 0.000) and to 65.25 ± 20.18 mg/dl in week 8 (P = 0.000). Levels of serum calcium, uric acid, SGOT, SGPT, and iPTH didn't change significantly. Compared to baseline, the platelet counts were decreased in both week 4 and week 8. No significant changes were observed in placebo group. In our patients, nicotinamide effectively decreased phosphorus, increased high-density lipoprotein, and caused thrombocytopenia. Since nicotinamide lowered platelet counts and caused thrombocytopenia in lower doses than other studies in these patients, it is necessary to plan other studies for assessing the safety of the drug especially in different populations.
  Nefrologia: publicacion oficial de la Sociedad Espanola Nefrologia 01/2011; 31(1):58-65. · 1.00 Impact Factor
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  Article: Effect of hyoscine-N-butyl bromide rectal suppository on labor progress in primigravid women: randomized double-blind placebo-controlled clinical trial.

  Somayeh Makvandi, Mitra Tadayon, Mohammadreza Abbaspour
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  ABSTRACT: To determine the effects of hyoscine-N-butyl bromide (HBB) rectal suppository on labor progress in primigravid women. A randomized double-blind placebo-controlled clinical trial was carried out on 130 primigravid women admitted for spontaneous labor. The women were recruited based on the inclusion and exclusion criteria and randomized into the experimental (n=65) and control group (n=65). In the beginning of the active phase of labor, 20 mg of HBB rectal suppository was administered to the experimental group, while a placebo suppository was administered to the control group. Cervical dilatation and duration of active phase and second stage of labor were recorded. The rate of cervical dilatation was 2.6 cm/h in the experimental and 1.5 cm/h in the control group (P<0.001). The active phase and the second stage of labor were significantly shorter in the experimental group (P=0.001 and P<0.001, respectively). There was no significant difference between the two groups in the fetal heart rate, maternal pulse rate, blood pressure, and the APGAR score 1 and 5 minutes after birth. Use of HBB rectal suppository in the active management of labor can shorten both the active phase and second stage of labor without significant side-effects.
  Croatian Medical Journal 04/2011; 52(2):159-63. · 1.80 Impact Factor