Research: Kyoto UniversityKyoto University · Department of Cardiovascular MedicineJapan · Kyoto
Teaching: lecturerOsaka University of PharmacyJapan · Osaka
Research: Research in clinical cardiology and basic research in cardiovascular pharmacologyUniversity of Manitoba · Division of Cardiology · Associate Profesor. Dr SW RabkinCanada · Winnipeg
Research: Correlative studies on electrocardiogram and histopathology of the conduction systemKyoto University · 3rd Division Of Intertnal Medicine · Prof.Dr.Chuichi KawaiJapan · Kyoto
Kyoto UniversityMedicine · M.D.Japan · Kyoto
Member of Japanese Circulation Society
Member of Japanese College of Cardiology
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ABSTRACT: There were few reports on the pathological characteristics of the conduction system in myocarditis. This study was aimed to clarify the pathological characteristics of complete atrioventricular (AV) block in myocarditis. We studied serial electrocardiograms in experimental myocarditis in mice and also examined their cardiac pathology. After taking baseline electrocardiograms, mice were inoculated intraperitoneally with the encephalomyocarditis virus. Electrocardiograms were serially recorded until day 360. Serial electrocardiograms revealed the appearance of complete AV block. Myocardial lesions were found in the hearts of mice with these ectopic beats. Mononuclear cell infiltrations into the His bundle and necrotic lesions of the conduction system were found in 10.7% (18/168) of mice with complete AV block. However, 17.3% (29/168) of mice showed no evident pathological lesions except the edematous changes of AV node. The appearance of complete AV block in myocarditis may suggest not only significantly comparable pathological lesions of the conduction system but also the trivial edematous changes; in clinical settings, in the former case, permanent pacing therapy is necessary, and in the latter case, the disease may be transient and could be recovered from complete AV block. This study may shed light on the pathological characteristics of complete AV block in myocarditis.Journal of Electrocardiology 08/2005; 38(3):230-4. · 1.14 Impact Factor
Article: The authors reply.Heart 10/1988; 60(3):265.
Article: Spontaneous resolution of a dissection of the descending aorta after medical treatment with a beta blocker and a calcium antagonist.[show abstract] [hide abstract]
ABSTRACT: A 58 year old man experienced an attack of squeezing chest pain. A contrast enhanced computed tomographic scan showed acute dissection of the descending aorta. Treatment with metoprolol and nicardipine kept his blood pressure below 130/90 mm Hg while he was supine at rest and after walking. Serial contrast enhanced computed tomographic scans showed opacification of the false lumen (which was not opacified initially) on the 42nd day; moderate regression of the false lumen on the 67th day, and resolution of the false lumen on the 266th day. This is the first in vivo demonstration of spontaneous resolution of aortic dissection detected by serial contrast enhanced computed tomographic scans.Heart 08/1987; 58(1):82-4.
Article: Antiarrhythmic effects of cyclic guanosine 3' :5'-monophosphate and sodium nitroprusside on barium chloride arrhythmias in rabbits.[show abstract] [hide abstract]
ABSTRACT: The hypothesis that c GMP and sodium nitroprusside (NP), an activator of guanylate cyclase which elevates levels of c GMP, have antiarrhythmic activity was tested in the barium chloride (BaCl2) model of arrhythmias. Electrocardiograms were recorded continuously on tape in unanesthetized New Zealand white rabbits weighing approximately 2.0 kg. BaCl2, 4 mg/kg i.v. bolus, induced frequent ventricular ectopic beats. These ventricular arrhythmias were abolished by 8-bromo-c GMP, 5 mg/kg, injected into the left ventricle (5/6 rabbits), NP 25.0 microgram/kg/min i.v. (6/6), NP 10 micrograms/kg/min i.v. (3/6), and markedly reduced in frequency by NP 10 micrograms/kg/min (3/6). In temporal association with NP, 4 fold increases in c GMP levels in blood and significant increases in myocardial GMP were found compared to control animals (n = 6). In this model, c GMP and NP have significant antiarrhythmic properties. NP effect may be mediated by alterations in c GMP metabolism.Archives internationales de pharmacodynamie et de thérapie. 07/1982; 257(2):225-38.
S W Rabkin, M Ohmae[show abstract] [hide abstract]
ABSTRACT: To develop a classification of ventricular ectopic beats based on the QRS complex, the frontal and precordial QRS vectors were examined in ECGs from 71 patients. The data were first analyzed in planar coordinates to permit comparison with some previous classifications. Next, because the QRS vector is angular data, the data were transformed to spherical coordinates. Multivariate statistical methods were used. Cluster analysis aided in the separation of groups. Although at least four groups were suggested using planar coordinates, only three groupings were identified on spherical coordinates. A classification function was developed that permits assignments of ectopies into these three groups. It correctly classified 97.2% of cases. Thus, this study provides a quantitative method that significantly defines groups of ventricular ectopic beats.Journal of Electrocardiology 01/1982; 15(1):55-60. · 1.14 Impact Factor