Maria V Ilina

Cardiology, Cardiothoracic Surgery, Pediatrics



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    ABSTRACT: Heart disease accounts for a significant proportion of sudden unexpected deaths among children. We describe here demographic features, pathological conditions, and the frequency of premonitory symptoms in a retrospective series of cases of sudden unexpected cardiac death (SUCD) attributable to undiagnosed structural heart disease. A chart review of autopsies involving children 0 to 17 years of age that were performed at the Hospital for Sick Children (Toronto, Ontario, Canada) between 1984 and 2003 was conducted. Cases of sudden unexpected death within 24 hours after clinical presentation with previously undetected fatal heart disease were included. Cases with multiple or thoracic trauma and chronic or multisystem disease were excluded. During the 20-year study period, 4926 autopsies were performed. A total of 103 cases (2.1%), involving 51 male patients and 52 female patients 1 day to 15 years of age (mean: 2.9 ± 4.2 years), were diagnosed as having SUCD. The most common diagnoses were myocarditis (n = 37 [35.9%]), hypoplastic left heart syndrome (HLHS) (n = 19 [18.4%]), dilated cardiomyopathy (DCM) (n = 16 [16.5%]), coronary artery anomalies (n = 6 [5.8%]), and aortic stenosis (n = 5 [4.9%]). There was a significant difference in the mean age of presentation between leading causes of SUCD (6.5 days for HLHS, 1.7 years for DCM, and 5.4 years for myocarditis; P < .0001). Of 103 cases, 27 (26.2%) had premonitory symptoms documented. SUCD accounted for 2.1% of all autopsies, and HLHS, DCM, and myocarditis were the 3 most common diagnoses, which presented at increasing ages.
    PEDIATRICS 08/2011; 128(3):e513-20. DOI:10.1542/peds.2010-2307 · 5.47 Impact Factor
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    ABSTRACT: Uhl's anomaly is a rare condition and surgical techniques are few and have had variable success. We present a novel and successful surgical technique to treat this difficult condition.
    The Annals of thoracic surgery 12/2010; 90(6):2076-8. DOI:10.1016/j.athoracsur.2009.12.084 · 3.85 Impact Factor
  • Maria Ilina · Martin Lowe · Jan Marek
    Pediatric Cardiology 11/2010; 32(1):119-20. DOI:10.1007/s00246-010-9848-9 · 1.31 Impact Factor
  • Maria V Ilina · Dominic J Abrams · Martin D Lowe · Jan Marek
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    ABSTRACT: Ventricular pre-excitation causing reversible left ventricular (LV) systolic dysfunction has been reported in adults and children. We describe severe heart failure secondary to ventricular pre-excitation in a 3-month-old girl who presented with echocardiographic evidence of marked intraventricular dyssynchrony. The patient was initially considered for transplantation, but dual chamber left atrioventricular epicardial pacing initiated at 4.5 months of age resulted in a marked clinical and echocardiographic improvement. Five years later, successful radiofrequency ablation resulted in loss of pre-excitation and reversal of LV dyssynchrony, thus allowing pacemaker explantation. To our knowledge, this is one of very few reported cases of pre-excitation-induced cardiomyopathy affecting a young infant and the only case palliated with resynchronization pacing.
    Pediatric Cardiology 08/2010; 31(6):897-900. DOI:10.1007/s00246-010-9733-6 · 1.31 Impact Factor
  • Maria V Ilina · Edgar T Jaeggi · Kyong-Jin Lee
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    ABSTRACT: We describe an infant with the antenatal diagnosis of a large intracardiac rhabdomyoma causing tricuspid inflow obstruction. Postnatal cyanosis and arterial hypoxemia prompted commencement of intravenous prostaglandin E1 with immediate improvement in saturations. Clinical and genetic testing confirmed diagnosis of tuberous sclerosis. To secure ductal patency, two tandem coronary stents were implanted via an antegrade approach. Several episodes of long RP atrio-ventricular re-entrant tachycardia were observed. At 7(1/2) months of age, the tumor was no longer obstructive to tricuspid inflow, ductal flow was highly restrictive and there was no recurrence of supraventricular tachycardia.
    Catheterization and Cardiovascular Interventions 05/2007; 69(6):881-5. DOI:10.1002/ccd.21064 · 2.11 Impact Factor

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