Publications (8) View all
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Article: Cerebellar deficits in schizophrenia are associated with executive dysfuntion
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ABSTRACT: Cerebellar abnormalities have been documented in schizophrenia in postmortem, functional and volumetric neuroimaging studies. This study aims to establish the relationship between structural changes in the cerebellum and executive dysfunction in patients with schizophrenia using voxel-based morphometry. We compared 28 outpatients with 28 healthy controls. A widely used executive battery and the voxel-based morphometry approach were used to investigate possible structural cerebellum changes on magnetic resonance imaging. Working memory dysfunctions in schizophrenia correlated with grey matter in both cerebellar hemispheres and vermis. Mental flexibility dysfunctions also correlated with reductions in white matter volume in bilateral cerebellum. This evidence supports the contribution of cerebellar grey and white matter deficits to executive dysfunctions observed in schizophrenia.Neuroreport 10/2008; 19(15):1513-1517. · 1.66 Impact Factor -
Article: Absence of additional cognitive impairment in schizophrenia patients during maintenance electroconvulsive therapy.
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ABSTRACT: This study examines the cognitive impairment profile of schizophrenia patients during maintenance electroconvulsive therapy (M-ECT). Ten schizophrenia patients treated with M-ECT and ten control patients matched for diagnosis, sex, and age who had never been treated with ECT were assessed with a comprehensive neuropsychological battery. M-ECT patients did not show a higher level of memory, attention, or frontal function impairment than the control group. The absence of additional memory dysfunction may favor the functional adaptation of these patients during M-ECT.Schizophrenia Bulletin 02/2004; 30(1):185-9. · 8.80 Impact Factor -
Article: Diez años de la Sociedad Española de Ciencias Forestales
Ería: Revista cuatrimestral de geografía, ISSN 0211-0563, Nº 58, 2002, pags. 268-271. -
Article: A continuous emotional task activates the left amygdala in healthy volunteers: (18)FDG PET study.
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ABSTRACT: Human amygdalar activation has been reported during facial emotion recognition (FER) studies, mostly using fast temporal resolution techniques (fMRI, H(2)(15)O PET or MEG). The (18)FDG PET technique has never been previously applied to FER studies. We decided to test whether amygdala response during FER tasks could be assessed with this technique. The study was conducted in 10 healthy right-handed volunteers who underwent two scans on different days in random order. Content of the tasks was either emotional (ET) or neutral (CT) and lasted for 17 (1/2) min. Three SPM2 analyses were completed. The first, an ET-CT contrast, showed left amygdalar activation. The second ruled out order effect as a confounder factor. Finally, the whole brain contrast showed activation of the emotional recognition-related areas. Time responses and errors indicated high rates of accuracy in both tasks. We discuss the results and the role of habituation phenomena and the possibility of applying this technique to samples of patients with psychiatric disorders. In conclusion, our study reveals left amygdalar activation assessed with FDG PET, as well as other major emotion recognition-related brain areas during FER tasks.Psychiatry Research 03/2009; 171(3):199-206. · 2.52 Impact Factor -
Article: Cerebellar deficits in schizophrenia are associated with executive dysfunction.
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ABSTRACT: Cerebellar abnormalities have been documented in schizophrenia in postmortem, functional and volumetric neuroimaging studies. This study aims to establish the relationship between structural changes in the cerebellum and executive dysfunction in patients with schizophrenia using voxel-based morphometry. We compared 28 outpatients with 28 healthy controls. A widely used executive battery and the voxel-based morphometry approach were used to investigate possible structural cerebellum changes on magnetic resonance imaging. Working memory dysfunctions in schizophrenia correlated with grey matter in both cerebellar hemispheres and vermis. Mental flexibility dysfunctions also correlated with reductions in white matter volume in bilateral cerebellum. This evidence supports the contribution of cerebellar grey and white matter deficits to executive dysfunctions observed in schizophrenia.Neuroreport 11/2008; 19(15):1513-7. · 1.66 Impact Factor
