Publications (46) View all
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Article: Incorporation of 6-Thioguanine Nucleotides into DNA During Maintenance Therapy of Childhood Acute Lymphoblastic Leukemia-The Influence of Thiopurine Methyltransferase Genotypes.
The Journal of Clinical Pharmacology 04/2013; · 2.91 Impact Factor -
Article: High Prevalence of Sacrococcygeal Teratoma in Finland - A Nationwide Population-Based Study.
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ABSTRACT: AIM: The birth prevalence of sacrococcygeal teratoma (SCT), has been reported to range from 1:27 000 to 1:40 000. We assessed the population-based prevalence and clinical presentation of SCT over 22 years. METHODS: We identified all cases of SCT, including live births, stillbirths and terminations of pregnancy (TOPs), in the Finnish Register of Congenital Malformations, covering 1987-2008. Data on prenatal diagnoses, pregnancy outcomes, infant deaths and associated anomalies were collected. RESULTS: 124 SCT cases were identified among 1 331 699 pregnancies. There were 89 (72%) live births, 13 (10%) stillbirths and 22 (18%) TOPs. The total prevalence of SCT was 1:10 700. Tumors were detected in utero in 55% of the pregnancies with SCT. The proportion of perinatal deaths among all SCT-births was 28%. Thirty percent of the cases had associated abnormalities (mainly of the urinary tract and various syndromes). CONCLUSION: This nationwide, population-based study on SCT shows that the total and birth prevalence of SCT in Finland is markedly higher than previously reported. This may reflect true differences between populations, but may also be explained by accurate nationwide registration of SCTs. The high perinatal mortality rate has an impact on counseling of families and planning of deliveries. ©2013 The Author(s)/Acta Paediatrica ©2013 Foundation Acta Paediatrica.Acta Paediatrica 02/2013; · 2.07 Impact Factor -
Article: [Childhood brain tumors].
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ABSTRACT: Brain tumors are the second most common pediatric neoplastic disease after leukemias. As causes of mortality and morbidity they add up to the most significant group of tumors. Treatment is based on thorough surgical excision of the tumor. Additional treatment with cytotoxic agents and radiotherapy is applied to malignant tumors. Treatment results have improved so that approximately three children out of four will make complete recovery from brain tumor. Long-term problems are, however, common and often significantly weakening the quality of life.Duodecim; lääketieteellinen aikakauskirja 01/2013; 129(3):235-43. -
Dataset: Palonkoski ym Duodecim 2012
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Article: Ewing's sarcoma family of tumors in Finland during 1990-2009: A population-based study.
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ABSTRACT: Background. Ewing's sarcoma family of tumors (ESFTs) are rare bone and soft tissue tumors characterized by specific genetic alterations. Our aim was to carry out a nationwide analysis of ESFT, to survey the treatments used and to report the five-year disease specific and event-free survival rates (EFS and DSS). Material and methods. The study data was gathered from the Finnish National Cancer Registry and all five University Hospitals and consisted of 76 bone and soft tissue ESFT patients diagnosed during 1990-2009. Their medical records were reviewed and data on their disease, treatments, complications and outcome were analyzed. Results. The five-year EFS and DSS of patients with localized disease at diagnosis (n = 57) were 70% and 60%, respectively. Factors contributing to DSS and EFS were the axial vs. peripheral site of primary tumor and adequate surgical resection of the primary tumor. DSS was also affected by patient's age at diagnosis and the treatment employed. The five-year DSS of patients with metastatic disease at diagnosis (n = 19) was 33% and both preoperative and high dose chemotherapy were associated with improved survival. Conclusion. Population-based studies including both bone and soft tissue ESFTs are few. In this nationwide, population-based study on Finnish bone and soft tissue ESFT patients, we find their treatment successful and results comparable to those previously published. Absence of metastases, young age at diagnosis and a peripheral primary tumor site were associated with a better prognosis. It seems that surgical resection of the primary tumor should be performed whenever adequate resection margins can be achieved. The role of high dose chemotherapy merits further studies in this setting.Acta oncologica (Stockholm, Sweden) 11/2012; · 2.27 Impact Factor
