Khalid Al-Hamdan

Publications

• 2.92

  Impact points

  Effect of implant surface properties on peri-implant bone healing: a histological and histomorphometric study in dogs.

  Khalid Al-Hamdan, Samar H Al-Moaber, Rüdiger Junker, John A Jansen

  Clinical oral implants research. 04/2011; 22(4):399-405.

  The present study aimed to evaluate and compare two types of implants, i.e. grit-blasted and acid-etched implants (SLActive(®)) with nano-meter-scale hydroxyapatite surface-modified implants (NanoTite™). For histological and histomorphometrical evaluation, 22 SLActive(®) and 22 Nanotite™ implants we... [more] The present study aimed to evaluate and compare two types of implants, i.e. grit-blasted and acid-etched implants (SLActive(®)) with nano-meter-scale hydroxyapatite surface-modified implants (NanoTite™). For histological and histomorphometrical evaluation, 22 SLActive(®) and 22 Nanotite™ implants were inserted in eleven Beagle dogs. The animals were divided into three groups of healing (A: 2 weeks; B: 4 weeks and C: 8 weeks). Two, 4 and 8 weeks after implantation, the animals were sacrificed and bone-to-implant contact (BIC %), first implant-bone contact (1st BIC) as well as amount of bone (BV) were assessed. For SLActive(®) and Nanotite™ implants, BIC% increased significantly over time. No statistically significant differences in BIC% were found between SLActive(®) and Nanotite™ at all the respective implantation times. Moreover, for the different healing periods, no significant differences for BV between SLActive(®) and Nanotite™ implants were found. The present study showed that SLActive(®) and NanoTite™ implants induce a similar bone response after implantation for 2, 4 and 8 weeks in a non-submerged position in the mandible of dogs.
• 1.41

  Impact points

  Root caries and risk profiles using the Cariogram in different periodontal disease severity groups.

  Hani Fadel, Khalid Al Hamdan, Yasser Rhbeini, Lars Heijl, Dowen Birkhed

  Acta odontologica Scandinavica. 03/2011; 69(2):118-24.

  To study root caries and risk profiles using the Cariogram in relation to periodontal disease severity and to analyse indicators associated with high caries risk. A cross-sectional examination was carried out on 112 patients with periodontal disease from two government clinics in Saudi Arabia. The i... [more] To study root caries and risk profiles using the Cariogram in relation to periodontal disease severity and to analyse indicators associated with high caries risk. A cross-sectional examination was carried out on 112 patients with periodontal disease from two government clinics in Saudi Arabia. The investigation comprised a questionnaire, bitewing radiographs, measurement of salivary secretion rate, buffering capacity and cariogenic microorganisms, and registration of periodontal status, plaque amount and coronal and root caries/fillings (DFT and RDFT). The data were then entered into the Cariogram pedagogic model to illustrate the caries risk profiles. Patients were grouped according to periodontal disease severity into one of three groups: (1) gingivitis (n = 44); (2) mild-to-moderate periodontitis (n = 33); and (3) severe periodontitis (n = 35). The prevalence of RDFT in the total sample was 17%. There were no statistically significant differences between the three groups in number of root lesions or mean 'Actual Chance to Avoid New Cavities' (Chance-AC) according to the Cariogram. Of the total sample, 22% displayed high caries risk (Chance-AC ≤ 40%). The most significant risk indicators in high caries risk patients were infrequent use of fluoride and unfavourable salivary and microbial parameters. Root surface lesions and high caries risk were present in about one-fifth of the patients referred for periodontal treatment. A combination of risk indicators rather than a single one contributed to the increased risk. Caries and risk profiles were not significantly correlated with periodontal disease severity.
• 2.95

  Impact points

  Effect of white-colored mineral trioxide aggregate in different concentrations on Candida albicans in vitro.

  Khalid Al-Hezaimi, Khalid Al-Hamdan, Jafar Naghshbandi, Samuel Oglesby, James H S Simon, Ilan Rotstein

  Journal of endodontics. 09/2005; 31(9):684-6.

  The antifungal action of different concentrations of white-colored mineral trioxide aggregate (MTA) against Candida albicans was assessed in vitro. Fresh mix of MTA was prepared at concentrations varying from 0.78 mg/ml to 50 mg/ml by dilution with 10 ml molten agar at 45 degrees C. The MTA-agar com... [more] The antifungal action of different concentrations of white-colored mineral trioxide aggregate (MTA) against Candida albicans was assessed in vitro. Fresh mix of MTA was prepared at concentrations varying from 0.78 mg/ml to 50 mg/ml by dilution with 10 ml molten agar at 45 degrees C. The MTA-agar compound was thoroughly mixed and the uniform mix was then poured into sterile Petri dishes and allowed to set. A total of 348 agar plates were prepared and divided into experimental groups of 11 plates each and control groups of 5 plates each. Plates of agar without MTA served as positive control and plates without C. albicans served as negative control. Fresh inoculate of C. albicans was prepared by growing an overnight culture from a stock culture. Aliquots of C. albicans were then taken from the stock culture and plated on the agar compound of the experimental and positive control groups. All plates were incubated at 37 degrees C for 1, 24, 48, and 72-h periods. At each time period, the presence of C. albicans colonies was assessed and recorded. A direct correlation was found between MTA concentration and its inhibition effect on C. albicans growth. Plates containing MTA in concentration of 50 mg/ml showed significantly better killing action against C. albicans in all of the time periods tested (p < 0.001). Plates containing MTA in concentration of 25 mg/ml showed antifungal activity only at 1 and 24-h time periods. Plates containing lower concentrations of MTA did not show any antifungal activity. It appears that under the conditions of this study, white-colored MTA in concentration of 50 mg/ml is effective in killing C. albicans for periods of up to 3 days. Lower MTA concentrations may not be effective.
• 2.19

  Impact points

  Guided tissue regeneration-based root coverage: meta-analysis.

  Khalid Al-Hamdan, Robert Eber, David Sarment, Charles Kowalski, Hom-Lay Wang

  Journal of periodontology. 10/2003; 74(10):1520-33.

  BACKGROUND: The goal of guided tissue regeneration-based root coverage (GTRC) is to repair gingival recession via new attachment formation. Numerous clinical trials have been conducted utilizing the concept of GTR to promote root coverage. Most GTRC studies have had relatively small sample sizes and... [more] BACKGROUND: The goal of guided tissue regeneration-based root coverage (GTRC) is to repair gingival recession via new attachment formation. Numerous clinical trials have been conducted utilizing the concept of GTR to promote root coverage. Most GTRC studies have had relatively small sample sizes and have not utilized power calculations to determine appropriate sample size; therefore, it is difficult to draw strong conclusions from them. Hence, the purpose of this study is to combine data from currently available GTRC studies and to use meta-analysis to determine whether GTRC provides significantly improved clinical outcomes compared to conventional periodontal plastic surgical approaches for the treatment of marginal tissue recession. METHODS: Studies were identified that used GTR approaches to treat gingival recession from January 1990 to October 2001. Information from each study was entered into a database. Data were analyzed according to the following criteria: GTRC versus conventional mucogingival surgery (CMGS); membrane type; root conditioning; pretreatment recession depth; adjunctive use of bone replacement graft (BRG); and source of funding. Studies were ranked independently, and mean data from each were weighted accordingly. Meta-analysis was performed using the weighted means for each group. Paired t tests were used to determine statistical significance between each pair of groups. RESULTS: Forty papers were included for analysis. GTRC resulted in an average of 74% recession depth reduction, 41% complete root coverage, 3 mm AL gain, and 1 mm KG gain. Both GTRC and CMGS produced significant (P < 0.05) improvement compared to baseline measurements. Compared to GTRC, CMGS resulted in significantly (P < 0.05) increased KG (2.1 mm vs. 1.1 mm), root coverage (81% vs. 74%), and percentage of defects with complete root coverage (55% vs. 41 %). Use of absorbable membranes, root conditioning, shallow pretreatment recession (< 4 mm), and corporate sponsorship all resulted in significantly (P < 0.05) improved percentages of sites with complete root coverage but had no effect on other parameters. CONCLUSIONS: Based on this meta-analysis, guided tissue regeneration-based root coverage can be used successfully to repair gingival recession defects. Conventional mucogingival surgery, however, resulted in statistically better root coverage, width of keratinized gingiva, and complete root coverage.

• Risk factors, indicators and predictors of periodontal disease.

  K al-Hamdan, P Richards, H L Wang

  The Journal of the Michigan Dental Association. 10/2001; 83(7):36-9, 68-71.
• 1.98

  Impact points

  Effect of implant surface properties on peri-implant bone healing: implant stability and microcomputed tomographic analysis.

  Samar H Al-Hamdan, Khalid Al-Hamdan, Rüdiger Junker, John A Jansen

  The International journal of oral & maxillofacial implants. 27(1):77-83.

  The present study aimed to evaluate and compare two types of implants: grit-blasted and acidetched implants (SLActive) and nanometer-scale hydroxyapatite-modified implants (NanoTite). Twenty-two SLActive and 22 NanoTite implants were inserted into the mandibles of 11 beagle dogs. The animals were di... [more] The present study aimed to evaluate and compare two types of implants: grit-blasted and acidetched implants (SLActive) and nanometer-scale hydroxyapatite-modified implants (NanoTite). Twenty-two SLActive and 22 NanoTite implants were inserted into the mandibles of 11 beagle dogs. The animals were divided into three groups according to healing time (group A, 2 weeks; group B, 4 weeks; group C, 8 weeks). Resonance frequency analysis (RFA) was performed immediately after implant placement and after 2, 4, and 8 weeks of healing. Two, 4, and 8 weeks after implantation, the animals were sacrificed and the amount of bone surrounding the implants was assessed using microcomputed tomography. For SLActive and NanoTite implants, the RFA values decreased after 2 weeks and increased after 4 and 8 weeks of healing. After 8 weeks, the mean RFA value for SLActive implants was significantly higher than the mean RFA value for NanoTite implants. For the different healing periods, no significant differences in bone volume were seen for SLActive and NanoTite implants. SLActive and NanoTite implants evoked a similar bone response after implantation for 2, 4, and 8 weeks in a nonsubmerged position in the mandibles of dogs. In addition, the data confirmed that RFA is a reliable and noninvasive method to determine dental implant stability and the bone formation process at the clinical level.

• Effect of White-Colored Mineral Trioxide Aggregate in Different Concentrations on Candida albicans In Vitro

  Khalid Al-Hezaimi, Khalid Al-Hamdan, Jafar Naghshbandi, Samuel Oglesby, James H.S. Simon, Ilan Rotstein

  Journal of Endodontics.

  The antifungal action of different concentrations of white-colored mineral trioxide aggregate (MTA) against Candida albicans was assessed in vitro. Fresh mix of MTA was prepared at concentrations varying from 0.78 mg/ml to 50 mg/ml by dilution with 10 ml molten agar at 45°C. The MTA-agar compound wa... [more] The antifungal action of different concentrations of white-colored mineral trioxide aggregate (MTA) against Candida albicans was assessed in vitro. Fresh mix of MTA was prepared at concentrations varying from 0.78 mg/ml to 50 mg/ml by dilution with 10 ml molten agar at 45°C. The MTA-agar compound was thoroughly mixed and the uniform mix was then poured into sterile Petri dishes and allowed to set. A total of 348 agar plates were prepared and divided into experimental groups of 11 plates each and control groups of 5 plates each. Plates of agar without MTA served as positive control and plates without C. albicans served as negative control. Fresh inoculate of C. albicans was prepared by growing an overnight culture from a stock culture. Aliquots of C. albicans were then taken from the stock culture and plated on the agar compound of the experimental and positive control groups. All plates were incubated at 37°C for 1, 24, 48, and 72-h periods. At each time period, the presence of C. albicans colonies was assessed and recorded. A direct correlation was found between MTA concentration and its inhibition effect on C. albicans growth. Plates containing MTA in concentration of 50 mg/ml showed significantly better killing action against C. albicans in all of the time periods tested (p < 0.001). Plates containing MTA in concentration of 25 mg/ml showed antifungal activity only at 1 and 24-h time periods. Plates containing lower concentrations of MTA did not show any antifungal activity. It appears that under the conditions of this study, white-colored MTA in concentration of 50 mg/ml is effective in killing C. albicans for periods of up to 3 days. Lower MTA concentrations may not be effective.