Kevin S Hughes

Publications (115) View all

• Article: The use of radiation in the elderly

  K. S.  Hughes 
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  ABSTRACT: Despite the fact that breast cancer is predominantly a disease of postmenopausal women, there have been no uniform recommendations for both locoregional and systemic therapy for women over 70. Until recently, older women have been excluded from clinical trials. This study is the first randomized trial that addresses the use of radiation therapy following lumpectomy in a favorable cohort of elderly women.
  Breast Cancer Online 12/2006; 10(01).
• Conference Proceeding: Oncology Lifeline - A Timeline Tool for the Interdisciplinary Management of Breast Cancer Patients in a Surgical Clinic.

  Brian Drohan, Georges G. Grinstein, Kevin Hughes
  14th International Conference on Information Visualisation, IV 2010, 26-29 July 2010, London, UK; 01/2010
• Article: Hereditary breast and ovarian cancer and other hereditary syndromes: using technology to identify carriers.

  Brian Drohan, Constance A Roche, James C Cusack, Kevin S Hughes
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  ABSTRACT: PURPOSE AND METHODS: Most patients who harbor a genetic mutation for hereditary breast cancer have not been identified, despite the availability of genetic testing. Developing an effective approach to the identification of high-risk individuals is the key to preventing and/or providing early diagnosis of cancer in this patient population. This educational review addresses these issues. RESULTS AND DISCUSSION: Using data available on the internet, and making assumptions regarding the types and results of genetic testing, we have estimated the number of mutation carriers in the country and the number who have been tested and identified as such. Overall, our ability to fund and more effectively manage carriers is weak. A technological solution is discussed.
  Annals of Surgical Oncology 03/2012; 19(6):1732-7. · 4.17 Impact Factor
• Article: Managing patients at high risk for hereditary breast cancer: a guide for the practicing physician.

  James C Cusack, Kevin S Hughes
  Annals of Surgical Oncology 03/2012; 19(6):1721-2. · 4.17 Impact Factor
• Article: Lumpectomy cavity shaved margins do not impact re-excision rates in breast cancer patients.

  Suzanne B Coopey, Julliette M Buckley, Barbara L Smith, Kevin S Hughes, Michele A Gadd, Michelle C Specht
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  ABSTRACT: The benefits of taking shaved cavity margins (SCM) at the time of lumpectomy are unclear. We sought to determine if taking SCM decreases re-excision rates by increasing the total breast tissue volume excised. We undertook a retrospective review of breast cancer patients who underwent lumpectomy from 2004 to 2006. Patients were divided into three groups. Group 1 had lumpectomy alone, group 2 had lumpectomy plus select (1-3) SCM, and group 3 had lumpectomy plus complete (≥4) SCM. Pathologic findings and surgical outcomes were compared between groups. 773 cancers treated by lumpectomy were included in this study; 197 were in group 1, 130 were in group 2, and 446 were in group 3. The mean total volume of breast tissue excised in group 1 (106.6 cm(3)) was significantly larger than the volume excised in groups 2 (79.3 cm(3)) and 3 (76.3 cm(3)). Rates of re-excision and successful breast-conservation therapy (BCT) were not significantly different between groups. Despite a lower total volume of breast tissue excised in groups 2 and 3, there was no significant increase in locoregional recurrence rates (LRR) at median follow-up of 54 months. Taking additional SCM during lumpectomy resulted in a significantly lower overall volume of breast tissue excised, with no increase in LRR. Contrary to prior studies, we found that SCM did not decrease re-excision rates or impact the success of BCT. Therefore, the main advantage of taking SCM appears to be that less breast tissue is excised, which could potentially improve cosmetic outcomes.
  Annals of Surgical Oncology 10/2011; 18(11):3036-40. · 4.17 Impact Factor