Katja van den Hurk

Publications

• 6.72

  Impact points

  Independent Associations of Glucose Status and Arterial Stiffness With Left Ventricular Diastolic Dysfunction: An 8-year follow-up of the Hoorn Study.

  Katja van den Hurk, Marjan Alssema, Otto Kamp, Ronald M Henry, Coen D Stehouwer, Yvo M Smulders, Giel Nijpels, Walter J Paulus, Jacqueline M Dekker

  Diabetes care. 03/2012;

  OBJECTIVETo investigate relative contributions of glucose status and arterial stiffness to markers of left ventricular (LV) systolic and diastolic dysfunction after 8 years of follow-up.RESEARCH DESIGN AND METHODSIn the population-based prospective Hoorn Study, 394 individuals with preserved LV syst... [more] OBJECTIVETo investigate relative contributions of glucose status and arterial stiffness to markers of left ventricular (LV) systolic and diastolic dysfunction after 8 years of follow-up.RESEARCH DESIGN AND METHODSIn the population-based prospective Hoorn Study, 394 individuals with preserved LV systolic and diastolic function participated, of whom 87 had impaired glucose metabolism and 128 had type 2 diabetes. Measurements including arterial ultrasound and echocardiography were performed according to standardized protocols.RESULTSThe presence of type 2 diabetes was associated with more severe LV systolic and diastolic dysfunction 8 years later: LV ejection fraction was 2.98% (95% CI 0.46-5.51) lower, and left atrial (LA) volume index, LV mass index, and tissue Doppler-derived E/e' were 3.71 mL/m(2) (1.20-6.22), 5.86 g/m(2.7) (2.94-8.78), and 1.64 units (0.95-2.33) higher, respectively. Furthermore, presence of impaired glucose metabolism or type 2 diabetes was associated with 8-year increases in LV mass index. More arterial stiffness (measured as a lower distensibility) was associated with LV diastolic dysfunction 8 years later: LA volume index, LV mass index, and E/e' at follow-up were higher. Subsequent adjustments for baseline mean arterial pressure and/or LV diastolic dysfunction did not eliminate these associations. Associations of type 2 diabetes and arterial stiffness with markers of LV diastolic dysfunction were largely independent of each other.CONCLUSIONSBoth glucose status and arterial distensibility are independently associated with more severe LV diastolic dysfunction 8 years later and with deterioration of LV diastolic dysfunction. Therefore, type 2 diabetes and arterial stiffness may relate to LV diastolic dysfunction through different pathways.
• 3.71

  Impact points

  Heart failure and cognitive function in the general population: the Hoorn Study.

  Katja van den Hurk, Yael D Reijmer, Esther van den Berg, Marjan Alssema, Giel Nijpels, Piet J Kostense, Coen D A Stehouwer, Walter J Paulus, Otto Kamp, Jacqueline M Dekker, Geert Jan Biessels

  European journal of heart failure. 12/2011; 13(12):1362-9.

  To examine whether reduced cognitive functioning can be observed in early stages of left ventricular (LV) dysfunction and heart failure. In 313 individuals aged 59-87 years from the longitudinal non-demented population-based Hoorn Study, echocardiography was performed to measure markers of LV systol... [more] To examine whether reduced cognitive functioning can be observed in early stages of left ventricular (LV) dysfunction and heart failure. In 313 individuals aged 59-87 years from the longitudinal non-demented population-based Hoorn Study, echocardiography was performed to measure markers of LV systolic and diastolic function at baseline (2000-01) and follow-up (2005-09), together with standardized physical examinations and brain natriuretic peptide (BNP) measurements. Heart failure was assessed echocardiographically at the follow-up examination only. Cognitive tests for information processing speed, memory, and attention and executive functioning were administered at follow-up. Linear regression analyses showed that baseline markers of LV diastolic function, but not LV systolic function, were associated with lower scores on attention and executive functioning at follow-up. Individuals with higher baseline BNP had lower scores on all three cognitive domains: standardized regression coefficients were -0.16 (-0.26 to -0.05), -0.17 (-0.28 to -0.05), and -0.28 (-0.37 to -0.19). Worse LV systolic and diastolic function at follow-up were associated with a worse performance on attention and executive functioning. Furthermore, individuals with heart failure at follow-up had lower scores on attention and executive functioning: -0.21 (-0.41 to -0.00). Higher BNP at follow-up was also associated with worse attention and executive functioning, even after adjustment for baseline BNP. Worse cognitive functioning can already be observed in early stages of LV dysfunction and heart failure. BNP is a target for further investigation as a risk factor for cognitive decline in the general population.
• 2.48

  Impact points

  Long-term exposure to traffic-related air pollution and type 2 diabetes prevalence in a cross-sectional screening-study in the Netherlands.

  Marieke B A Dijkema, Sanne F Mallant, Ulrike Gehring, Katja van den Hurk, Marjan Alssema, Rob T van Strien, Paul H Fischer, Giel Nijpels, Coen D A Stehouwer, Gerard Hoek, Jacqueline M Dekker, Bert Brunekreef

  Environmental health : a global access science source. 09/2011; 10:76.

  Air pollution may promote type 2 diabetes by increasing adipose inflammation and insulin resistance. This study examined the relation between long-term exposure to traffic-related air pollution and type 2 diabetes prevalence among 50- to 75-year-old subjects living in Westfriesland, the Netherlands.... [more] Air pollution may promote type 2 diabetes by increasing adipose inflammation and insulin resistance. This study examined the relation between long-term exposure to traffic-related air pollution and type 2 diabetes prevalence among 50- to 75-year-old subjects living in Westfriesland, the Netherlands. Participants were recruited in a cross-sectional diabetes screening-study conducted between 1998 and 2000. Exposure to traffic-related air pollution was characterized at the participants' home-address. Indicators of exposure were land use regression modeled nitrogen dioxide (NO2) concentration, distance to the nearest main road, traffic flow at the nearest main road and traffic in a 250 m circular buffer. Crude and age-, gender- and neighborhood income adjusted associations were examined by logistic regression. 8,018 participants were included, of whom 619 (8%) subjects had type 2 diabetes. Smoothed plots of exposure versus type 2 diabetes supported some association with traffic in a 250 m buffer (the highest three quartiles compared to the lowest also showed increased prevalence, though non-significant and not increasing with increasing quartile), but not with the other exposure metrics. Modeled NO2-concentration, distance to the nearest main road and traffic flow at the nearest main road were not associated with diabetes. Exposure-response relations seemed somewhat more pronounced for women than for men (non-significant). We did not find consistent associations between type 2 diabetes prevalence and exposure to traffic-related air pollution, though there were some indications for a relation with traffic in a 250 m buffer.
• 4.36

  Impact points

  Type 2 diabetes strengthens the association between pulse pressure and chronic kidney disease: the AusDiab study.

  Katja van den Hurk, Dianna J Magliano, Marjan Alssema, Markus P Schlaich, Robert C Atkins, Anne T Reutens, Giel Nijpels, Jacqueline M Dekker, Jonathan E Shaw

  Journal of hypertension. 02/2011; 29(5):953-60.

  Chronic kidney disease (CKD) is a serious disorder with significant public health impact. Identification of factors associated with risk of progression of kidney disease may help in earlier intervention in high-risk groups. We investigated whether brachial pulse pressure (PP) was associated with 5-y... [more] Chronic kidney disease (CKD) is a serious disorder with significant public health impact. Identification of factors associated with risk of progression of kidney disease may help in earlier intervention in high-risk groups. We investigated whether brachial pulse pressure (PP) was associated with 5-year changes in estimated glomerular filtration rate (eGFR) and incident CKD and whether type 2 diabetes modified these associations. In the population-based Australian Diabetes, Obesity and Lifestyle Study (AusDiab) 5554 individuals (5.8% with type 2 diabetes) who took part in the 5-year follow-up and had no CKD or microalbuminuria at baseline were included. After adjusting for baseline age, sex, eGFR and use of blood pressure-lowering medication, each baseline SD higher PP was associated with a decline in eGFR of 0.32 ml/min (P=0.006) and an odds ratio (OR) for CKD of 1.29 [95% confidence interval (CI) 1.09-1.53] in individuals without type 2 diabetes. In individuals with type 2 diabetes, eGFR declined by 1.10 ml/min (P=0.011) and the OR for incident CKD was 1.94 (1.14-3.29). Similar associations with eGFR decline were observed with systolic blood pressure and incident CKD in individuals without type 2 diabetes. In individuals with type 2 diabetes, higher systolic blood pressure was only significantly associated with eGFR decline if the diastolic blood pressure was 70 mmHg or less (P for interaction between systolic and diastolic blood pressure: 0.033). PP is an important risk factor for eGFR decline and incident CKD over a 5-year period, especially in individuals with type 2 diabetes.
• 3.71

  Impact points

  Slightly elevated B-type natriuretic peptide levels in a non-heart failure range indicate a worse left ventricular diastolic function in individuals with, as compared with individuals without, type 2 diabetes: the Hoorn Study.

  Katja van den Hurk, Marjan Alssema, Otto Kamp, Ronald M Henry, Coen D Stehouwer, Michaela Diamant, Frans Boomsma, Rob J Heine, Giel Nijpels, Walter J Paulus, Jacqueline M Dekker

  European journal of heart failure. 09/2010; 12(9):958-65.

  Higher plasma B-type natriuretic peptide (BNP) in a non-heart failure (HF) range predicts HF and cardiovascular disease (CVD) mortality in the general population. Heart failure is highly prevalent in type 2 diabetes mellitus (T2DM), but associations of BNP to left ventricular (LV) mass and function ... [more] Higher plasma B-type natriuretic peptide (BNP) in a non-heart failure (HF) range predicts HF and cardiovascular disease (CVD) mortality in the general population. Heart failure is highly prevalent in type 2 diabetes mellitus (T2DM), but associations of BNP to left ventricular (LV) mass and function in individuals with a different glucose status have not been compared. We therefore aimed to explore (i) the association of BNP levels in a non-HF range with structural and functional markers of LV function, and (ii) possible effect modification by glucose tolerance categories. Linear regression analyses were performed to investigate associations of BNP with 2D echocardiographic measures of LV mass index, LV systolic function, and markers of LV diastolic function in a population-based study of men and women with normal glucose metabolism (NGM, n = 197), impaired glucose metabolism (IGM, n = 128), or T2DM (n = 204). Patients were aged between 50 and 87 years, had BNP levels below 50 pmol/L, and no LV wall motion abnormalities. B-type natriuretic peptide levels ranged from 0.4 to 46.1 pmol/L, the median was 4.2 pmol/L. Higher BNP was significantly associated with increased LV mass and deteriorated LV diastolic function, but not with LV systolic function. B-type natriuretic peptide was more strongly associated with LV diastolic function in T2DM compared with NGM and IGM. B-type natriuretic peptide was associated with LV mass and markers of LV diastolic function, and the association of BNP with the latter appeared to be particularly strong in individuals with T2DM. This implies that the presence or absence of T2DM should be taken into account if BNP levels are used to assess CVD risk.
• 2.79

  Impact points

  Prevalence of overweight and obesity in the Netherlands in 2003 compared to 1980 and 1997.

  Katja van den Hurk, Paula van Dommelen, Stef van Buuren, Paul H Verkerk, Remy A Hirasing

  Archives of disease in childhood. 12/2007; 92(11):992-5.

  OBJECTIVE: To assess the prevalence of overweight and obesity in children living in the Netherlands and compare the findings with the Third and Fourth National Growth Studies carried out in 1980 and 1997, respectively. DESIGN AND METHODS: Data were obtained from the child health care system. Interna... [more] OBJECTIVE: To assess the prevalence of overweight and obesity in children living in the Netherlands and compare the findings with the Third and Fourth National Growth Studies carried out in 1980 and 1997, respectively. DESIGN AND METHODS: Data were obtained from the child health care system. International cut-off points for body mass index (BMI) were used to determine overweight and obesity. Cases were weighted for ethnicity and municipality size in such a way that the sample matched the distribution in the general population. The LMS method was used to calculate the age-related distribution of BMI, and the prevalence was calculated from the fitted distribution. Patients: Data on 90 071 children aged 4-16 years were routinely collected by 11 community health services during 2002-2004. RESULTS: On average, 14.5% of the boys and 17.5% of the girls were overweight (including obesity), which is a substantial increase since 1980 (boys 3.9%, girls 6.9%) and 1997 (boys 9.7%, girls 13.0%). Similarly, 2.6% of the boys and 3.3% of the girls aged 4-16 years were obese, which is much higher than in 1980 (boys 0.2%, girls 0.5%) and 1997 (boys 1.2%, girls 2.0%). At the age of 4, 12.3% of the boys and 16.2% of the girls were already overweight. CONCLUSIONS: The prevalence of overweight and obesity in the Netherlands is still rising, and at an even faster rate than before. Evidence-based interventions are needed to counter the obesity epidemic, and there is an urgent need for pre-school intervention programmes.

• Snelle toename gewicht bij kinderen tussen de 4 en 15 jaar.

  K. van den Hurk, P. van Dommelen, J.A. de Wilde, P H Verkerk, S van Buuren, R A Hirasing

• Prevalence of overweight and obesity in The Netherlands in 2003 compared to 1980 and 1997

  K. van den Hurk, P. van Dommelen, S van Buuren, P H Verkerk, R A Hirasing

  Objective: To assess the prevalence of overweight and obesity in children living in the Netherlands and compare the findings with the Third and Fourth National Growth Studies carried out in 1980 and 1997, respectively. Design and methods: Data were obtained from the child health care system. Interna... [more] Objective: To assess the prevalence of overweight and obesity in children living in the Netherlands and compare the findings with the Third and Fourth National Growth Studies carried out in 1980 and 1997, respectively. Design and methods: Data were obtained from the child health care system. International cut-off points for body mass index (BMI) were used to determine overweight and obesity. Cases were weighted for ethnicity and municipality size in such a way that the sample matched the distribution in the general population. The LMS method was used to calculate the age-related distribution of BMI, and the prevalence was calculated from the fitted distribution. Patients: Data on 90 071 children aged 4–16 years were routinely collected by 11 community health services during 2002–2004. Results: On average, 14.5% of the boys and 17.5% of the girls were overweight (including obesity), which is a substantial increase since 1980 (boys 3.9%, girls 6.9%) and 1997 (boys 9.7%, girls 13.0%). Similarly, 2.6% of the boys and 3.3% of the girls aged 4–16 years were obese, which is much higher than in 1980 (boys 0.2%, girls 0.5%) and 1997 (boys 1.2%, girls 2.0%). At the age of 4, 12.3% of the boys and 16.2% of the girls were already overweight. Conclusions: The prevalence of overweight and obesity in the Netherlands is still rising, and at an even faster rate than before. Evidence-based interventions are needed to counter the obesity epidemic, and there is an urgent need for pre-school intervention programmes.

• Prevalentie van overgewicht en obesitas bij jeugdigen 4-15 jaar in de periode 2002-2004

  K. van den Hurk, P. van Dommelen, J.A. de Wilde, P H Verkerk, S van Buuren, R A Hirasing

  Uit de cijfers blijkt een toename van overgewicht, maar met name van obesitas. Daarmee is duidelijk dat de obesitas epidemie zich ook in Nederland voortzet. Interventies ter voorkoming van overgewicht en obesitas zijn daarom noodzakelijk. Deze interventies dienen op (kosten)effectiviteit te worden g... [more] Uit de cijfers blijkt een toename van overgewicht, maar met name van obesitas. Daarmee is duidelijk dat de obesitas epidemie zich ook in Nederland voortzet. Interventies ter voorkoming van overgewicht en obesitas zijn daarom noodzakelijk. Deze interventies dienen op (kosten)effectiviteit te worden geëvalueerd. De JGZ is de aangewezen instantie voor signalering en preventieve interventies. Vroegsignalering lijkt met name bij meisjes noodzakelijk, omdat de prevalentie van overgewicht bij meisjes op vijfjarige leeftijd al hoog is. Hiertoe is het waarschijnlijk ook nodig om seksespecifieke interventieprogramma’s aan te raden, omdat meisjes op jongere leeftijd dan jongens te zwaar worden. De al ontwikkelde standaarden van de Lokale en Nationale Monitor Jeugdgezondheid moeten in de Nederlandse JGZ worden toegepast. Het hebben van elektronische registratie in de JGZ zal het verkrijgen van gegevens vergemakkelijken. Op korte termijn zullen veel organisaties echter nog afhankelijk zijn van schriftelijke registraties. Onderzocht moet worden of in de JGZ volgens het (signalerings)protocol wordt gemeten en geregistreerd, om de vergelijkbaarheid van de gegevens van verschillende JGZ organisaties te kunnen bepalen.