Publications (10) View all
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Article: Porous ceramic titanium dioxide scaffolds promote bone formation in rabbit peri-implant cortical defect model.
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ABSTRACT: Titanium oxide (TiO(2)) scaffolds have previously been reported to exhibit very low mechanical strength. However, we have been able to produce a scaffold that features a high interconnectivity, a porosity of 91% and a compressive strength above 1.2MPa. This study analyzed the in vivo performance of the porous TiO(2) scaffolds in a peri-implant cortical defect model in the rabbit. After 8weeks of healing, morphological microcomputed tomography analyses of the defects treated with the TiO(2) scaffolds had significantly higher bone volume, bone surface and bone surface-to-volume ratio when compared to sham, both in the cortical and bone marrow compartment. No adverse effects, i.e. tissue necrosis or inflammation as measured by lactate dehydrogenase activity and real-time reverse transcription polymerase chain reaction analysis, were observed. Moreover, the scaffold did not hinder bone growth onto the adjacent cortical titanium implant. Histology clearly demonstrated new bone formation in the cortical sections of the defects and the presence of newly formed bone in close proximity to the scaffold surface and the surface of the adjacent Ti implant. Bone-to-material contact between the newly formed bone and the scaffold was observed in the histological sections. Islets of new bone were also present in the marrow compartment albeit in small amounts. In conclusion, the present investigation demonstrates that TiO(2) scaffolds osseointegrate well and are a suitable scaffold for peri-implant bone healing and growth.Acta biomaterialia 09/2012; · 3.98 Impact Factor -
Article: Bone formation in TiO2 bone scaffolds in extraction sockets of minipigs.
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ABSTRACT: The osteoconductive capacity of TiO(2) scaffolds was investigated by analysing the bone ingrowth into the scaffold structure following their placement into surgically modified extraction sockets in Gottingen minipigs. Non-critical size defects were used in order to ensure sufficient bone regeneration for the evaluation of bone ingrowth to the porous scaffold structure, and sham sites were used as positive control. Microcomputed tomographic analysis revealed 73.6±11.1% of the available scaffold pore space to be occupied by newly formed bone tissue, and the volumetric bone mineral density of the regenerated bone was comparable to that of the native cortical bone. Furthermore, histological evidence of vascularization and the presence of bone lamellae surrounding some of the blood vessels were also observed within the inner regions of the scaffold, indicating that the highly interconnected pore structure of the TiO(2) scaffolds supports unobstructed formation of viable bone tissue within the entire scaffold structure. In addition, bone tissue was found to be in direct contact with 50.0±21.5% of the TiO(2) struts, demonstrating the good biocompatibility and osteoconductivity of the scaffold material.Acta biomaterialia 03/2012; 8(6):2384-91. · 3.98 Impact Factor -
Article: Porous titanium granules in the surgical treatment of peri-implant osseous defects: a randomized clinical trial.
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ABSTRACT: Porous titanium granules (PTG) may have potential as an osteoconductive bone graft substitute to treat peri-implant osseous defects. The aim of this study was to analyze clinical and radiographic outcomes of peri-implant osseous defects after treatment with PTG. This prospective, randomized, case-control, clinical 12-month study compared open-flap debridement and surface decontamination with titanium curettes and 24% ethylenediaminetetraacetic acid gel (n = 16) to the same protocol but with the addition of PTG (n = 16). One-, two-, and three-wall infrabony defects were included. Patients were given amoxicillin and metronidazole 3 days before surgery and for 7 days afterwards. Implants were submerged and allowed to heal for 6 months. Probing pocket depths, bleeding on probing, implant stability using resonance frequency analysis, and radiographic evaluation were performed at baseline and at 12 months. The threshold for significance was set at .05. Change in radiographic defect height and percent fill of the peri-implant osseous defect significantly favored patients treated with PTG. Both treatment modalities demonstrated significant improvements in probing pocket depth, but significant differences between groups were not observed. The PTG-treated implants showed an increase in implant stability quotient (ISQ) of 1.6 units, compared with a decrease of 0.7 ISQ for the control group. No adverse effects were associated with PTG treatment. Reconstruction with PTG resulted in significantly better radiographic peri-implant defect fill compared with controls; however, the results do not necessarily imply reosseointegration or osseointegration of PTG particles. Improvements in clinical parameters were seen in both groups, but no differences between groups were demonstrated.The International journal of oral & maxillofacial implants 03/2012; 27(2):401-10. · 1.78 Impact Factor -
Article: Dimensional Ridge Preservation with a Novel Highly Porous TiO(2) Scaffold: An Experimental Study in Minipigs.
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ABSTRACT: Despite being considered noncritical size defects, extraction sockets often require the use of bone grafts or bone graft substitutes in order to facilitate a stable implant site with an aesthetically pleasing mucosal architecture and prosthetic reconstruction. In the present study, the effect of novel TiO(2) scaffolds on dimensional ridge preservation was evaluated following their placement into surgically modified extraction sockets in the premolar region of minipig mandibles. After six weeks of healing, the scaffolds were wellintegrated in the alveolar bone, and the convex shape of the alveolar crest was preserved. The scaffolds were found to partially preserve the dimensions of the native buccal and lingual bone walls adjacent to the defect site. A tendency towards more pronounced vertical ridge resorption, particularly in the buccal bone wall of the nongrafted alveoli, indicates that the TiO(2) scaffold may be used for suppressing the loss of bone that normally follows tooth extraction.International Journal of Biomaterials 01/2012; 2012:851264. -
Article: The effect of permanent grafting materials on the preservation of the buccal bone plate after tooth extraction: an experimental study in the dog.
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ABSTRACT: The aim of the present study was to evaluate the effects of a novel bone substitute system (Natix(®)), consisting of porous titanium granules (PTG) and a bovine-derived xenograft (Bio-Oss(®)), on hard tissue remodelling following their placement into fresh extraction sockets in dogs. Six modalities were tested; Natix(®) granules with and without a covering double-layered Bio Gide(®) membrane; Bio-Oss(®) with and without a covering double-layered Bio Gide(®) membrane; and a socket left empty with and without a covering double-layered Bio Gide(®) membrane. Linear measurements, indicative of buccal bone height loss, and an area measurement indicative of buccal bulk bone loss were made. The statistical analysis was based on the Latin Square design with two blocking factors (dog and site). Tukey's post hoc test was used to adjust for multiple comparisons. Histological observation revealed that while bone formed around both the xenograft and the titanium particles, bone was also noted within titanium granules. Of the five modalities of ridge preservation techniques used in this study, no one technique proved to be superior. The titanium granules were observed to have promising osseoconductive properties.Clinical Oral Implants Research 07/2011; 23(8):911-7. · 2.51 Impact Factor
