Jacqueline M Vink

Publications (81) View all

• Source

  Available from: Diane J Lamb

  Article: Effects of Chorionicity and Zygosity on Triplet Birth Weight

  D J Lamb, J M vink, C M middeldorp, C E M van Beijsterveldt, M C haak, L C Overbeek, D I Boomsma
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  ABSTRACT: Triplets often have a low birth weight. This is partly due to low gestational age; they are often born premature. However, zygosity and chorionicity also affect birth weight. Triplets, which refers to one child (the set of three triplets is referred to as a 'trio'), can be either monochorionic (MC), dichorionic (DC) or trichorionic (TC). A smaller number of chorions is associated with lower birth weight because sharing a placenta causes competition for nutrients (Adegbite, Ward, & Bajoria, 2005; Bajoria, Ward, & Adegbite, 2006; Geipel et al., 2005). In addition, there is some evidence that when more triplets share a chorion the gestational age of the trio is lower (Spencer et al., 2009). Zygosity also is an important factor in birth weight, but is not independent from chorionicity. Monozygotic (MZ) triplets can share one chorion, can be DC, or have each their own chorion (i.e. trichorionic, TC); dizygotic (DZ) triplets are DC or TC; trizygotic (TZ) triplets are always RECEIVED 24 December, 2011; ACCEPTED 10 January, 2012.
  Twin Research and Human Genetics 01/2012; 15(10-2):149--157. · 1.70 Impact Factor
• Source

  Available from: Daníel Fannar Guðbjartsson

  Article: Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM.

  N Amin, E Byrne, J Johnson, G Chenevix-Trench, S Walter, I M Nolte, J M Vink, R Rawal, M Mangino, A Teumer, [......], H Tiemeier, B H R Wolfenbuttel, B A Oostra, A C Heath, E Wichmann, T D Spector, H J Grabe, D I Boomsma, N G Martin, C M van Duijn
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  ABSTRACT: Coffee consumption is a model for addictive behavior. We performed a meta-analysis of genome-wide association studies (GWASs) on coffee intake from 8 Caucasian cohorts (N=18 176) and sought replication of our top findings in a further 7929 individuals. We also performed a gene expression analysis treating different cell lines with caffeine. Genome-wide significant association was observed for two single-nucleotide polymorphisms (SNPs) in the 15q24 region. The two SNPs rs2470893 and rs2472297 (P-values=1.6 × 10(-11) and 2.7 × 10(-11)), which were also in strong linkage disequilibrium (r(2)=0.7) with each other, lie in the 23-kb long commonly shared 5' flanking region between CYP1A1 and CYP1A2 genes. CYP1A1 was found to be downregulated in lymphoblastoid cell lines treated with caffeine. CYP1A1 is known to metabolize polycyclic aromatic hydrocarbons, which are important constituents of coffee, whereas CYP1A2 is involved in the primary metabolism of caffeine. Significant evidence of association was also detected at rs382140 (P-value=3.9 × 10(-09)) near NRCAM-a gene implicated in vulnerability to addiction, and at another independent hit rs6495122 (P-value=7.1 × 10(-09))-an SNP associated with blood pressure-in the 15q24 region near the gene ULK3, in the meta-analysis of discovery and replication cohorts. Our results from GWASs and expression analysis also strongly implicate CAB39L in coffee drinking. Pathway analysis of differentially expressed genes revealed significantly enriched ubiquitin proteasome (P-value=2.2 × 10(-05)) and Parkinson's disease pathways (P-value=3.6 × 10(-05)).
  Molecular psychiatry 08/2011; 17(11):1116-29. · 15.05 Impact Factor
• Article: Heritability of polycystic ovary syndrome in a Dutch twin-family study.

  J M Vink, S Sadrzadeh, C B Lambalk, D I Boomsma
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  ABSTRACT: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders among women of reproductive age. There is evidence for a genetic component in PCOS based on familial clustering of cases. In the present study, the heritability of PCOS was estimated. Data from 1332 monozygotic twins (genetically identical) and 1873 dizygotic twins/singleton sisters of twins (who share on average 50% of their segregating genes) registered with The Netherlands Twin Register were used. PCOS was defined as less than nine menstrual cycles and acne or hirsutism in agreement with the 2003 Rotterdam consensus. Results point to a strong contribution of familial factors to PCOS. The resemblance in monozygotic twin sisters (tetrachoric correlation 0.71) for PCOS was about twice as large as in dizygotic twin and other sisters (tetrachoric correlation 0.38). Univariate analyses point to strong contributions of genetic factors to the variance in PCOS. Next, a trivariate genetic analysis of oligomenorrhea, acne, and hirsutism was carried out. This analysis confirmed that the familial component in PCOS is due to genetic factors. This study demonstrated a large influence of genetic factors to the pathogenesis of PCOS, justifying the search for susceptibility genes.
  Journal of Clinical Endocrinology &amp Metabolism 07/2006; 91(6):2100-4. · 6.50 Impact Factor
• Source

  Available from: Michael C Neale

  Article: Linkage analysis of smoking initiation and quantity in Dutch sibling pairs.

  J M Vink, A L Beem, D Posthuma, M C Neale, G Willemsen, K S Kendler, P E Slagboom, D I Boomsma
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  ABSTRACT: The heritability of smoking initiation (SI) and number of cigarettes smoked (NC) was determined in 3657 Dutch twin pairs. For SI a heritability of 36% was found and for NC of 51%. Both SI and NC were also significantly influenced by environmental factors shared by family members. The etiological factors that influence these traits partly overlap. Linkage analyses were performed on data of 536 DZ twins and siblings from 192 families, forming 592 sibling pairs. Results suggested QTLs on chromosome 6 (LOD=3.05) and chromosome 14 (LOD=1.66) for SI and on chromosome 3 (LOD=1.98) for NC. Strikingly, on chromosome 10 a peak was found in the same region for both SI (LOD=1.92) and for NC (LOD=2.29) which may partly explain the overlapping etiological factors for SI and NC.
  The Pharmacogenomics Journal 02/2004; 4(4):274-82. · 4.54 Impact Factor
• Source

  Available from: psu.edu

  Article: Genetic analysis of morningness and eveningness.

  J M Vink, A S Groot, G A Kerkhof, D I Boomsma
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  ABSTRACT: We studied the influence of genetic factors on individual differences in morningness-eveningness in a sample of Dutch twin families. Data were collected from adolescent twins (mean age 17.8 yr) and their parents (mean age of fathers 48.0 yr and of mothers 46.0 yr) and a sample of older twins (mean age 46.5 yr). Scores on morningness-eveningness were rated on a 5-point scale. Parents were more morning oriented than their children, and women were more morning oriented than men. With a twin-family study, separation of genetic and environmental influences on variation in morningness-eveningness is possible. Including parents and older twins in the study makes it possible to explore generation differences in these effects. The correlation between monozygotic twins was more than twice the correlation between dizygotic twins. This indicates that genetic effects may not operate in an additive manner. Therefore, a model that included genetic dominance was explored. Biometrical model fitting showed no sex differences for the magnitude of genetic and environmental factors. The total heritability--the sum of additive and nonadditive genetic influences--for morningness-eveningness was 44% for the younger generation and 47% for the older generation. However, the genetic correlation between the generations turned out to be lower than 0.5, suggesting that different genes for morningness-eveningness are expressed in both generations.
  Chronobiology International 10/2001; 18(5):809-22. · 4.03 Impact Factor