John Ogunbileje

Publications

• Hiv And Helicobacter Pylori Co-Infection In Dyspeptic Patients In Abeokuta, Nigeria

  Ejilude O, Akinduti P.A, Idowu M, Ogunbileje J.O, Akinbo J.A

  New York Science Journal. 09/2011; 4(9):1-5.

  Synergistic severity of H. pylori and HIV co-infection in dyspeptic patients and its seroprevalence by socio-economic and environmental factors in this locality was studied. 109 confirmed seropositive HIV patients suffering from dyspepsia were tested for the presence of H. pylori IgG antibodies from... [more] Synergistic severity of H. pylori and HIV co-infection in dyspeptic patients and its seroprevalence by socio-economic and environmental factors in this locality was studied. 109 confirmed seropositive HIV patients suffering from dyspepsia were tested for the presence of H. pylori IgG antibodies from 230 patients, attending outpatient clinics of Sacred Heart Hospital, Abeokuta, Nigeria. 47.4% has H. pylori and HIV antibodies with significant H. pylori IgG titre more than 1:40. 29.4% was recorded in age group 26-35 while 3.5% was recorded in 66-75. Female subjects were more predisposed having 52.7% to the disease while 27.5% have malaria as associated disease. Unemployed individuals are 17.4% with a significant titre of 1:60 compare to artisan with 36.7% prevalence rate but with low titre of 1:20. Low CD4 count of 213cell/mm3 among 17.4% unemployed and 405 cell/mm3 among 36.7% artisan was observed. Prevalence of H. pylori in HIV is correlated to poor socio-economic condition (that is low daily income), associated low-level of education and overcrowding which could predispose many HIV seropositive individuals to severe dyspepsia and other severe disease conditions.

• Biochemical and Haematological Profile in Nigerian Cement Factory Workers

  Ogunbileje J.O, Akinosun O.M

  Research Journal of Environmental Toxicology. 03/2011; 5:133-140.

  Cement dust exposures has been reported to result in various occupational health problems and long term complications. However, effects of cement dust exposures on biochemical, oxidative stress indicators and Haematological profiles in Nigerians cement factory workers are scarce, therefore the prese... [more] Cement dust exposures has been reported to result in various occupational health problems and long term complications. However, effects of cement dust exposures on biochemical, oxidative stress indicators and Haematological profiles in Nigerians cement factory workers are scarce, therefore the present study is aimed at determining the effects of cement dust exposure on uric acid, creatinine, total protein, albumin, globulin, copper and selenium levels and Haematological profile in forty-five cement factory workers and thirty controls office workers. Uric acid, creatinine, albumin and total protein were determined using Hitachi 902 auto analyser, total globulin was computed by subtracting albumin level from total protein concentration while haematological parameters were determined using Sysmex. Uric acid, copper and creatinine levels were significantly higher in cement factory workers compared with controls (p<0.05). Also, haemoglobulin, haematocrite concentration, Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin Concentration (MCHC), Mean Corpuscular Hemoglobin (MCH), lymphocytes and eosinophils are significantly higher in exposed group compared with controls while neutrophils were significantly lower in cement factory workers. Significantly higher creatinine suggests nephrotoxic effects while uric acid probably in part up regulated to combat oxidative stress. Uric acid was also significantly positively correlated with Body Mass Index (BMI) (r = 0.38, p<0.05), probably to match the body cement dust burdens. Higher haematological profile probably support the report that cement mill workers are exposed to metals that enhance haematopoietic system while the insignificant difference of total protein, albumin suggest that cement dust does not have effects on the synthetic functions of liver. Other variables did not differ significantly.

• SERUM LEVELS OF SOME TRACE METALS AND LEUCOCYTE DIFFERENTIAL COUNTS IN NIGERIAN CEMENT FACTORY WORKERS WORKING IN DIFFERENT SECTIONS:POSSIBLE TOXICITY IMPLICATION

  OGUNBILEJE JO, AKINOSUN OM, AKINDUTI PA, NWONBI NL, EJILUDE OA

  European Journal of Scientific Research. 01/2010;

  It has recently been reported that workers in cement factory are exposed to some trace metals in excess of the general population and these have been implicated in diseases incidence in cement factory workers. Studies examining the extent of exposure of workers in different departments of cement fac... [more] It has recently been reported that workers in cement factory are exposed to some trace metals in excess of the general population and these have been implicated in diseases incidence in cement factory workers. Studies examining the extent of exposure of workers in different departments of cement factory to these trace metals are not available, thus, necessitate this study. The present study determines the serum levels of some essential trace metals (chromium, copper, manganese, zinc, selenium and iron) and blood leucocyte differential counts in 45 cement factory workers ( packing and loading (13), milling (19) and crushing and earth movement section (13) ) working in different sections of the factory in a Nigeria cement factory. Serum chromium, copper, manganese, zinc, selenium and iron were determined using flame atomic absorption spectrophotometer while leucocyte differential (neutrophils, lymphocytes, eosinophils, monocytes and basophils) counts were determined manually. Serum levels of selenium, copper and iron were significantly higher (p<0.05) in workers working in the packing and loading section relative to the other two groups. While chromium was significantly higher (p<0.05) in workers in milling section. Also, eosinophils and monocyte were significantly higher in workers working in milling section. Though, workers in packing section have higher mean levels of lymphocyte and neutrophils, the levels were not statistically significant (p>0.05). This study suggest that workers in packing and loading section are more liable to come down with toxic effects of these trace metals if exposure rate is not control, followed by workers in milling section and this is reflected in significant increase in allergy markers (eosinophils and monocytes), thus, possible toxicity implications.

• Immunoglobulin Classes (IgG , IgA, IgM and IgE) and Liver Function Tests in Nigerian Cement Factory Workers

  OGUNBILEJE J.O, AKINOSUN O.M, ARINOLA O.G, AKINDUTI P.A

  RESEARCHER. 01/2010; 2:55-58.

  Abstract: Crystalline silica has recently been reported to act as an adjuvant which increases inflammation and antibody production. On the basis of new knowledge, it is possible that cement dust may have effects on the immune functions of cement factory workers. Previous studies on Nigerian cement f... [more] Abstract: Crystalline silica has recently been reported to act as an adjuvant which increases inflammation and antibody production. On the basis of new knowledge, it is possible that cement dust may have effects on the immune functions of cement factory workers. Previous studies on Nigerian cement factory workers were concentrated on the pulmonary function tests, chronic obstructive pulmonary disease (COPD), prevalence of chest infections and liver function tests neglecting the immune parameters of the cement workers. The present study determines the levels of serum immunoglobulin classes (IgA, IgM, IgG & IgE) and Alanine aminotransaminase, Alkaline phosphatase, total bilirubin and gamma glutamyl transferase in 45 male cement factory workers that are occupationally exposed to cement dust compared with 30, age and sex-matched, office workers that were not resident in the town of study. Immunodiffusion method was used to determine serum IgA, IgM, IgG while ELISA method was used to determine serum IgE. Alkaline phosphatase(ALP), alanine amino transferase(ALT), bilirubin were determined using Hitachi 902 auto analyser while gamma glutamyl transferase(GGT) was determined using colorimetric method. The levels of IgM and IgA were not statistically different in cement factory workers compared with control (p>0.05) while IgG and IgE were significantly higher in cement factory workers (p<0.05) when compared with corresponding levels in the controls. Also, ALP and bilirubin were higher in the test subjects than in control group (p<0.05). Though the mean levels of ALT and GGT were not statistically significantly higher cement factory workers when compared with control group (p>0.05). This study demonstrated that higher level of IgG may be a mechanism to block anaphylaxis reaction of IgE in Nigerian cement factory workers. The raised ALP and bilirubin levels may suggest hepatotoxic effects of cement dust. [Researcher 2010;2(4):55-58]. (ISSN: 1553-9865). Key-words: Silica, Cement dust, Nigeria, Immunoglobulin, Liver.

• Immunoglobulin Classes (IgG , IgA, IgM and IgE) and Liver Function Tests in Nigerian Cement Factory Workers

  OGUNBILEJE J.O, AKINOSUN O.M, ARINOLA O.G, AKINDUTI P.A

  (5TH Biennial Scientific Conference of Association of Clinical Chemists of Nigeria and Inauguration of African Federation of Clinical Chemistry, Ibadan, Nigeria, Ibadan, Nigeria; 01/2009

• Prevalence of Enterhaemorragic Esherichia coli 0157:H7 Causing Severe Urinary Tract Infection in Abeokuta, Nigeria.

  AKINDUTI P.A, AKINBO J.A, EJILUDE O.A, MANI-UDOH M.I, UMAHOIN K.O, OGUNBILEJE J.O, FOLARIN B.O

  The journal of American Science. 01/2008; 2:4-9.

  ABSTRACT: Increasing renal debility among various age groups in recent past has shifted public attention on the prevalence of renal diseases caused by enterohaemorrhagic eschericia coli serotype 0157:H7 (EHEC 0157:H7) in Abeokuta, Nigeria as a result of consumption of unproperly cooked meal especial... [more] ABSTRACT: Increasing renal debility among various age groups in recent past has shifted public attention on the prevalence of renal diseases caused by enterohaemorrhagic eschericia coli serotype 0157:H7 (EHEC 0157:H7) in Abeokuta, Nigeria as a result of consumption of unproperly cooked meal especially of bovine source. This study spanned through a period of 23 months between February 2006 to November 2007 with total urine sample of 1205 from various age group including known UTI patients and related diseases (988) and Non-UTI patient 217 which serves as control group. All the urine samples were investigated for EHEC 0157:H7. E.coli serotype accounted for 372(46.4%) of all the isolates like Pseudomonas aeruginosa 74(9.2), Staphlococcus albus 122(15.2), Proteus mirabilis 51(6.4%), klebsiella specie 147(18.3%), staphylococcus aureus 36(4.5%).Age group 41-50 male shows highest prevalence of 1/3(33%) , while female age group 6-10 having 1/11(9.0%), 11-20(6.7%). 21-30, 6/8(7.5%), 41-50 ½(8.3%), suggesting that female were more predisposed to UTI and its related diseases. Incidence of E.coli0157:H7 in chronic PID and gynaecological condition having 1/9(11.1%) inferred that E.coli0157:H7 could as well be responsible to this disease condition and foetal debilities. Most of the isolates were verocyto-toxin producers with 112 out of 223(5.4%) in severe UTI and all produce type-1 and 2 verocytotoxin and likewise in chronic PID and gyaenecology conditions. This study shows a very high prevalence of E.coli0157:H7 in this area which could be a major aetiological cause of renal diseases. Attention should be more paid to undiagnosed hemolytic colitis and hemolytic uremic syndrome caused as a result of severe UTI in developing countries with aggressive strategic public health campaign in preventing secondary transmission .The study is statistically significant (p<0.05). [The Journal of American Science. 2008; 4(2):4-9].