Publications (25) View all
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Article: Episodes of status epilepticus in young adults: Etiologic factors, subtypes, and outcomes.
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ABSTRACT: The aim of this study was to evaluate the type, duration, etiology, treatment, and outcome of status epilepticus (SE) episodes, among patients aged 16-50years. A total of 101 SE episodes in 88 young adult patients fulfilled our criteria. The mean age was 32years. Status epilepticus episodes were most frequently observed in patients 21-30years of age. A total of 53% of the patients were male, and 57% had pre-existing epilepsy. Seventy of the 101 episodes were convulsive SE. The most common etiology was withdrawal of or change in antiepileptic drugs (AEDs), seen in 31% of the SE episodes. This study included treatment of SE with traditional AEDs. Sixty-six episodes were treated successfully with intravenous infusion of 18-mg/kg phenytoin, and six episodes were treated with 10-mg/kg phenytoin. A total of 28% of the SE episodes remained refractory to first-line treatment, which was related to the duration of SE and mortality. The outcome was death in 14% of the patients due to underlying etiologies in the hospital.Epilepsy & Behavior 03/2013; 27(2):351-354. · 2.34 Impact Factor -
Article: Politerapi Kullanan Epilepsi Hastalarının Monoterapi Kullanan Hastalardan Farklılıkları
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ABSTRACT: Amaç: Bu çalışmanın amacı politerapi altındaki (birden fazla antiepileptik kullanan) epilepsi hastalarının demografik, klinik, nörolojik muayene ve görüntüleme sonuçlarının incelenerek politerapi ihtiyacına eşlik eden faktörlerin belirlenmesidir. Hastalar ve Yöntem: Marmara Üniversite Hastanesi Epilepsi polikliniğinde takipli 785 epileptik hastanın dosyası retrospektif olarak taranıp, hazırlanan formlar doldurulmuştur. Hastalar monoterapi ya da politerapi kullanmalarına göre gruplanmıştır. İki grup demografik veriler, klinik özellikler, nörolojik muayene ve görüntüleme sonuçları açısından Student-t ve ki-kare testleri ile karşılaştırılmıştır. Bulgular: Politerapi kullanan hasta grubunda öyküde kraniyotomi, intrakraniyal tümör, basit parsiyel nöbet ve konvülsif status epileptikus, nörolojik muayenede patolojik bulgu görülmesi, EEG, kranial görüntüleme (MR/BT) ve SPECT'de patoloji saptanması monoterapi kullanan hasta grubundan daha yüksek bulunmuştur. Sonuç: Politerapi epilepsi tedavisinde önemli bir basamaktır. Ancak ilaç-ilaç etkileşimi olasılığı ve artan ilaç yan etkileri nedeniyle ilk seçenek olarak kabul edilmemektedir. Politerapi kullanacak hastaların monoterapi ile nöbetleri kontrol altına alınabilen hastalardan farklılıkların belirlenmesi, politerapi ihtiyacının tedavinin öncesinde tahmin edilmesi açısından faydalı olacaktır. (Marmara Üniversitesi Tıp Fakültesi Dergisi 2012;25:123-7) Anahtar Kelimeler: Epilepsi, Politerapi, Etyoloji Abstract Objective: This study aimed to evaluate demographical variables, clinical features, neurological examination and cranial imaging results which cause or determine the necessity for politherapy treatment in epilepsy patients.Marmara Medical Journal 01/2012; -
Article: The effects of verbal reaction time in Alzheimer's disease.
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ABSTRACT: Verbal fluency deteriorates with normal aging, but is much more severe in Alzheimer's Disease (AD). Verbal functions were analyzed to find differences between normal aging subjects in patients with mild cognitive impairment (MCI), and in patients with early and moderate stages of AD. This study measured the verbal response time in patients with AD, MCI, and in control subjects This study measured the verbal response time in patients with AD, MCI, and in control subjects Fifteen patients with MCI, 15 patients with early AD, 8 patients with moderate AD, and 15 subjects for controls were included in the study. Word length in milliseconds, reaction time to a phoneme, word, or sentence and acoustic analysis of voice quality and speech diadochokinetic rate (DDK) were measured. Reaction time for a phoneme, word, or sentence especially the initiation period for them were longer in patients with early AD compared to patients with MCI (P < .001). The mean DDK rate was lower with increased severity of the disease, and was much more severe in patients with moderate AD. Clinical discrimination of the early stages of AD and MCI is challenging. Unfortunately, there are no laboratory markers present for the diagnosis of preclinical cases of AD. With the results of this study, the assessments of verbal reaction time may helpful for diagnosis of early AD.The Laryngoscope 07/2011; 121(7):1495-503. · 1.75 Impact Factor -
Article: Brain tumor presenting with psychiatric symptoms.
The Journal of neuropsychiatry and clinical neurosciences 01/2011; 23(4):E43-4. · 2.34 Impact Factor -
Article: Coincidental Onset of Ischemic and Hemorrhagic Stroke in The Brainstem
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ABSTRACT: Coincidence of ischemic and hemorrhagic stroke in the acute phase is a rare condition. A patient with uncontrolled hypertension and hypercholesterolemia presented with a sudden onset mild hand paresis that rapidly evolved to hemiparesis over the next few hours. Neuroradiologic investigations revealed a right-sided acute hemipons infarct and a hemorrhage in the anterior territory of infarction. Uncontrolled atherosclerotic risk factors such as hypertension and hyperlipidemia together with antithrombotic therapy seem to be the major reasons for the coincidental presence of both ischemic and hemorrhagic lesions in this patient.Journal of Neurological Sciences. 01/2010;
