Ignazio Stanganelli

Publications (45) View all

• Article: Changes observed in slow-growing melanomas during long-term dermoscopic monitoring.

  V Terushkin, S W Dusza, A Scope, G Argenziano, P Bahadoran, L Cowell, V De Giorgi, G Ferrara, H Kittler, J Malvehy, S Menzies, D Piccolo, S Puig, P Rubegni, I Stanganelli, L Thomas, I Zalaudek, A A Marghoob
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  ABSTRACT: Melanomas vary in growth rate from rapidly developing nodular melanomas to slow-growing melanomas (SGM) that hardly change over years. To evaluate longitudinal changes in dermoscopic findings of SGM. We retrospectively analysed a dermoscopic image dataset from 15 pigmented lesion clinics, of SGM that were followed sequentially by digital dermoscopy for at least 1 year. We evaluated baseline and follow-up images for changes in global pattern, organization, colours, structure and size. Our series consisted of 92 SGM. On follow-up, these melanomas developed the following dermoscopic findings: more homogeneous and less reticular global dermoscopic pattern; more frequent disorganization of pattern (baseline, 67% vs. follow-up, 79%); decreased prominence of light brown colour, increased prominence of dark brown colour, and increased frequency of the colours red, white, grey, blue and black (baseline: 29%, 3%, 18%, 6% and 33% vs. follow-up: 41%, 10%, 31%, 13% and 45%, respectively); decrease in prominence of dermoscopic structure of pigmented network, with a concomitant increase in prominence of structureless areas; and increased prominence or new appearance of melanoma-specific dermoscopic structures, including negative network, blue-white structures and blotches. The majority of lesions (75%) remained the same size or grew by < 2 mm in diameter. An increase in lesion size was associated with change in the total number of colours and structures (χ(2) = 14·3, P = 0·027) at follow-up. While their diameter changed minimally over time, most SGM became more disorganized, revealed loss of network in favour of structureless areas, and developed new colours.
  British Journal of Dermatology 01/2012; 166(6):1213-20. · 3.67 Impact Factor
• Article: Dermoscopy of scalp tumours: a multi-centre study conducted by the international dermoscopy society.

  I Stanganelli, G Argenziano, F Sera, A Blum, F Ozdemir, I K Karaarslan, D Piccolo, K Peris, H Kirchesch, R Bono, [......], S Astorino, A M Manganoni, J-Y Gourhant, J Keir, J M Grichnik, G Fumo, H Dong, A M Sortino Rachou, G Ferrara, I Zalaudek
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  ABSTRACT: Little is known about the dermoscopic features of scalp tumours. Objective  To determine the dermoscopic features of scalp tumours. Retrospective analysis of dermoscopic images of histopathologically diagnosed scalp tumours from International Dermoscopy Society members. A total of 323 tumours of the scalp from 315 patients (mean age: 52 years; range 3-88 years) were analysed. Scalp nevi were significantly associated with young age (<30 years) and exhibited a globular or network pattern with central or perifollicular hypopigmentation. Melanoma and non-melanoma skin cancer were associated with male gender, androgenetic alopecia, age >65 years and sun damage. Atypical network and regression were predictive for thin (≤1 mm) melanomas, whereas advanced melanomas (tumour thickness > 1 mm) revealed blue white veil, unspecific patterns and irregular black blotches or dots. The data collected provide a new knowledge regarding the clinical and dermoscopy features of pigmented scalp tumours.
  Journal of the European Academy of Dermatology and Venereology 07/2011; 26(8):953-63. · 2.98 Impact Factor
• Article: Confocal microscopy of recurrent naevi and recurrent melanomas: a retrospective morphological study.

  C Longo, E Moscarella, P Pepe, A M Cesinaro, A Casari, M Manfredini, I Stanganelli, S Gardini, C Cota, G Argenziano, G Pellacani, I Zalaudek
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  ABSTRACT: Repigmentation within a scar after different procedures (shave biopsy, partial excision, cryotherapy, laser) is a challenging diagnostic situation. To determine distinct dermoscopic and confocal microscopic features in a series of histopathologically proven melanocytic proliferations within a scar. Clinical, dermoscopic and confocal microscopic images were acquired before surgical excision in seven patients with repigmentation within a scar. The evaluation of the dermoscopic and confocal features was performed in blind to the final histopathological diagnosis that was obtained in all cases. Dermoscopically, the repigmentation in recurrent naevi (three patients) was confined within the scar while it extended beyond the scar in melanomas. This clue was more evident upon reflectance confocal microscopy (RCM). Confocally, recurrent naevi failed to exhibit prominent pagetoid or lateral spread of melanocytes and atypical nests at the junction, even though some cases showed atypical cells in the junctional component. However, these were few in number and cytologically monomorphous and allowed the diagnosis of a benign neoplasm with confidence. On the other hand, melanomas arising on a scar (four patients) revealed dendritic-shaped melanocytes arranged in sheets, and pagetoid and lateral spread of dendritic cells extending beyond the scar. Those confocal aspects were well correlated with the histopathological findings. The integration of clinical, dermoscopic and RCM aspects offers the possibility to discern reliably the nature in cases of repigmentation on a scar.
  British Journal of Dermatology 03/2011; 165(1):61-8. · 3.67 Impact Factor
• Source

  Available from: Masaru Tanaka

  Article: Accuracy in melanoma detection: a 10-year multicenter survey.

  Giuseppe Argenziano, Lorenzo Cerroni, Iris Zalaudek, Stefania Staibano, Rainer Hofmann-Wellenhof, Nicola Arpaia, Renato Marchiori Bakos, Brigitte Balme, Jadran Bandic, Roberto Bandelloni, [......], Fezal Ozdemir, Giovanni Pellacani, Stefania Seidenari, Katherine Siamas, Ignazio Stanganelli, William V Stoecker, Masaru Tanaka, Luc Thomas, Philipp Tschandl, Harald Kittler
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  ABSTRACT: Early excision is the only strategy to reduce melanoma mortality, but unnecessary excision of benign lesions increases morbidity and healthcare costs. To assess accuracy in melanoma detection based on number-needed-to-excise (NNE) values over a 10-year period. Information was retrieved on all histopathologically confirmed cutaneous melanomas or melanocytic nevi that were excised between 1998 and 2007 at participating clinics. NNE values were calculated by dividing the total number of excised lesions by the number of melanomas. Analyses included changes in NNE over time, differences in NNE between specialized clinical settings (SCS) versus non-specialized clinical settings (NSCS), and patient factors influencing NNE. The participating clinics contributed a total of 300,215 cases, including 17,172 melanomas and 283,043 melanocytic nevi. The overall NNE values achieved in SCS and NSCS in the 10-year period were 8.7 and 29.4, respectively. The NNE improved over time in SCS (from 12.8 to 6.8), but appeared unchanged in NSCS. Most of the effect on NNE in SCS was due to a greater number of excised melanomas. Higher NNE values were observed in patients younger than 40 years and for lesions located on the trunk. No data concerning the use of dermatoscopy and digital monitoring procedures were collected from the participating centers. Over the 10-year study period, accuracy in melanoma detection improved only in specialized clinics maybe because of a larger use of new diagnostic techniques such as dermatoscopy.
  Journal of the American Academy of Dermatology 10/2011; 67(1):54-9. · 3.99 Impact Factor
• Article: Size Functions for the Morphological Analysis of Melanocytic Lesions.

  Massimo Ferri, Ignazio Stanganelli
  Int. J. Biomedical Imaging. 01/2010; 2010.