Hung Tran Manh

Publications (54) View all

• Article: Arginase II inhibitory activity of flavonoid compounds from Scutellaria indica.

  Sang Won Kim, To Dao Cuong, Tran Manh Hung, Sungwoo Ryoo, Jeong Hyung Lee, Byung Sun Min
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  ABSTRACT: Arginase II has recently reported as a novel therapeutic target for the treatment of cardiovascular diseases such as atherosclerosis. In the course of screening plants used in natural medicines as arginase II inhibitory activity, a methanol extract of Scutellaria indica showed significant inhibitory effect. Further fractionation and repeated column chromatography led to the isolation of a new flavan-type (1), and seven known compounds (2-8). The chemical structures of isolated compounds were elucidated based on extensive 1D and 2D NMR spectroscopic data. The isolates 1-8 were investigated in vitro for their arginase II inhibitory activity using enzyme solution prepared from kidney of anesthetized C57BL/6 mice. Compounds 3 and 5 significantly inhibited arginase II activity with IC50 values of 25.1 and 11.6 μM, respectively, whereas the other compounds were apparently inactive.
  Archives of Pharmacal Research 04/2013; · 1.59 Impact Factor
• Article: Inhibitory effect on NO production of triterpenes from the fruiting bodies of Ganoderma lucidum.

  Nguyen The Tung, To Dao Cuong, Tran Manh Hung, Jeong Hyung Lee, Mi Hee Woo, Jae Sue Choi, Jaewang Kim, Sung Ho Ryu, Byung Sun Min
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  ABSTRACT: Four new lanostane triterpenes, butyl lucidenate P (1), butyl lucidenate D(2) (2), butyl lucidenate E(2) (3) and butyl lucidenate Q (4) along with 11 known compounds (5-15) were isolated from the fruiting bodies of Ganoderma lucidum. Their chemical structures were established mainly by 1D and 2D NMR techniques and mass spectrometry. Their anti-inflammatory activity was evaluated against LPS-induced NO production in macrophage RAW 264.7 cells. Compounds 1, 3, 4, 9, 10 and 15 showed inhibitory potency with IC(50) values of 7.4, 6.4, 4.3, 9.4, 9.2 and 4.5μM, respectively. Compounds 1, 3 and 15 dose-dependently reduced the LPS-induced iNOS expressions. Preincubation of cell with 1, 3 and 15 significantly suppressed LPS-induced expression of COX-2 protein.
  Bioorganic & medicinal chemistry letters 01/2013; · 2.65 Impact Factor
• Article: Phenolic Compounds from Caesalpinia sappan Heartwood and Their Anti-inflammatory Activity.

  To Dao Cuong, Tran Manh Hung, Jin Cheol Kim, Eun Hee Kim, Mi Hee Woo, Jae Sue Choi, Jeong Hyung Lee, Byung Sun Min
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  ABSTRACT: Four new phenolic compounds, caesalpiniaphenols A-D (1-4), together with eight known compounds were isolated from Caesalpinia sappan heartwood. The chemical structures were established mainly by NMR, MS, ECD, and Mosher's method. Compounds 4, 5, and 7 showed weak inhibitory activity against the LPS-induced NO production in macrophage RAW264.7 cells with IC(50) values of 12.2, 3.5, and 5.7 μM, respectively.
  Journal of Natural Products 12/2012; · 3.13 Impact Factor
• Article: Apoptosis-inducing and Antitumor Activity of Neolignans Isolated from Magnolia officinalis in HeLa Cancer Cells.

  Ui Joung Youn, Nighat Fatima, Quan Cheng Chen, Sungwook Chae, Tran Manh Hung, Byung-Sun Min
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  ABSTRACT: Two neolignans, 4'-methoxymagndialdehyde (1) and magnaldehyde B (2), were isolated from the stem bark of Magnolia officinalis (Magnoliaceae), evaluated for apoptosis-inducing effects in human cervical epitheloid carcinoma HeLa cells. The apoptosis-inducing activity of compounds 1 and 2 were assessed by DNA content using flow cytometric analysis. In the immunoblotting analysis, the treatment with 1 and 2 resulted in the cleavage of procaspase-8 and -3 and poly(ADP-ribose)polymerase into active forms. In addition, in vivo, the administration of 2 to Lewis lung carcinoma-inoculated mice evidenced a significant inhibition of tumor growth (volume) with reduction of 28.7% at concentration of 20 mg/kg, as compared with the control mice. These findings suggest that 2 can inhibit the proliferation of tumor cells, and might be an anti-tumoric agent. Copyright © 2012 John Wiley & Sons, Ltd.
  Phytotherapy Research 11/2012; · 2.09 Impact Factor
• Article: Compounds from the heartwood of Caesalpinia sappan and their anti-inflammatory activity.

  Byung Sun Min, To Dao Cuong, Tran Manh Hung, Bo Kyung Min, Beom Soo Shin, Mi Hee Woo
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  ABSTRACT: Two new phenolics, (3S,4R)-3,7,2',3'-tetrahydroxy-3,4-dihydro-9H-indeno[6,5-c]chromene (caesalpiniaphenol E, 1), and (3R,4S)-3,7-dihydroxy-3-(3'-methoxy-4'-hydroxyphenyl)-4-methoxychroman (caesalpiniaphenol F, 2), together with eleven known compounds (3-13), were isolated from the heartwood of Caesalpinia sappan. Their chemical structures were established mainly by 1D and 2D NMR techniques and mass spectrometry. Their anti-inflammatory activity was evaluated against LPS-induced NO production in macrophage RAW264.7 cells. Among them, compounds 10 and 13 showed strong inhibitory activities toward the LPS-induced NO production in macrophage RAW264.7 cells, with IC(50) values of 12.5 and 8.1μm, respectively. In addition, compounds 10 and 13 inhibited the inductions of iNOS mRNA in dose-dependent manners, indicating that these compounds attenuated the synthesis of these transcripts at the transcriptional level.
  Bioorganic & medicinal chemistry letters 10/2012; · 2.65 Impact Factor