Publications

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    ABSTRACT: In recent years, some studies were conducted to evaluate the effects of stem cells from different sources on patients with spinal cord injury (SCI). This study was carried out to evaluate the feasibility and therapeutic potential of autologous bone marrow cell (BMC) transplantation in 11 complete spinal cord injured patients at thoracic level. This nonrandomized clinical trial compared the results of autologous BMC transplantation into cerebrospinal fluid (CSF) via lumbar puncture (LP) in 11 patients having complete SCI, with 20 patients as control group who received conventional treatment without BMC transplantation. The patients underwent preoperative and follow-up neurological assessments using the American Spinal Injury Association (ASIA) impairment scale. Then, the participants were followed for 12-33 months. Eleven patients with the mean age of 33.2±8.9 years and 20 patients with the mean age of 33.5±7.2 years were enrolled in the study and in the control group, respectively. None of the patients in the study and control group experienced any adverse reaction and complications, neither after routine treatment nor after cell transplantation. Five patients out of 11 (45.5%) in the study group and three patients in the control group (15%) showed marked recovery, but the result was statistically borderline (P=0.095). We conclude that transplantation of autologous BMC via LP is a feasible and safe technique, but at the moment, no clear answer can be given regarding the clinical potential, despite a potential tendency to treat SCI patients, observed through statistics.
    Clinical neurology and neurosurgery 03/2012; 114(7):935-9. · 1.30 Impact Factor
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    ABSTRACT: Hossein Eskandary1, Mohsen Basiri1, Seyed Noureddin Nematollahi-Mahani2, Sepideh Mehravaran31Neuroscience Research Center, 2Department of Anatomy, Afzalipour School of Medicine, Kerman University of Medical Sciences, 3Afzal Research Institute, Kerman, IranAbstract: Glioma remains the most challenging solid organ tumor to treat successfully. Based on the capacity of stem cells to migrate extensively and target invading glioma cells, the transplantation of stem cells as a cell-based delivery system may provide additional tools for the treatment of gliomas. In addition to the use of modified stem cells for the delivery of therapeutic agents, unmodified stem cells have been shown to have growth-suppressing effects on tumors in vitro and in vivo. This review outlines the probable factors involved in tumor tropism and tumor growth suppression, with a specific focus on the use of unmodified stem cells in the treatment of gliomas. Based on these and further future data, clinical trials may be justified.Keywords: stem cell, brain tumor, glioma, tropism, growth suppression
    Biologics: Targets & Therapy 01/2011;
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    ABSTRACT: An experimental study to measure the depth of penetration of new vessels in degenerated intervertebral disc in rat. To evaluate the effects of atorvastatin on angiogenesis in experimental disc degeneration in rat. Back pain is strongly associated with degenerated intervertebral disc and management of this condition is still empirical. Decrease of nucleus nutrition due to loss of vascularity with aging may aggravate the process of disc degeneration. So, angiogenesis may be useful in the healing process of degenerated disc. In this study, we wanted to evaluate the effect of atorvastatin, whose stimulating effect on angiogenesis on other tissues was shown in several studies, on degenerated intervertebral disc in rat. Atorvastatin was administered intraperitoneally for 6 weeks in doses of 1, 4, and 8 mg/kg in rats after experimental disc degeneration. The rats intervertebral disc sections were stained immunohistochemically for von Willebrand Factor to evaluate the depth of vessels penetration and degree of vascularity. In the nonoperated control group, the intervertebral discs were avascular. But experimental disc degeneration promoted angiogenesis. In this group, the mean of penetration was 49.25 μ (standard deviation = 19.905). Atorvastatin stimulated angiogenesis after experimental disc degeneration in the rats and the angiogenesis was more significant in the high and medium dose groups than operated control group. High-dose atorvastatin could not inhibit angiogenesis in experimental degenerated disc. There was no any significant difference in degree of vascularity among the groups. Atorvastatin stimulates angiogenesis in experimental disc degeneration in rats. But, it does not show a biphasic effect.
    Spine 11/2010; 36(22):1824-8. · 2.16 Impact Factor
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    ABSTRACT: This study measured the frequency of lumbar intervertebral disc nucleus pulposus microscopic calcification and angiogenesis in adult patients undergoing discectomy compared to normal cadavers. The results were compared to determine the relationship between disc microscopic calcification with disc degeneration type, histopathological angiogenesis, patients' age, gender, and duration of symptoms. True frequency of microscopic calcification in normal or degenerated lumbar discs have not been fully defined nor linked to disc degeneration type and angiogenesis. Some studies demonstrated that angiogenesis and calcification are related to each other in several another tissues. The frequency of microscopic calcification in specimens of disc nucleus pulpous obtained from 2 groups were measured: specimens were obtained during surgery from 90 consecutive patients of 15 to 50 years old suffering from disc herniation in single level of L4-L5 or L5-S1 between 2005 and 2006, 60 additional specimens of lumbar disc nucleus pulposus were obtained from normal cadavers of the same ages. Calcification was determined microscopically by Von Kossa staining and angiogenesis by H/E, and type of degeneration radiologically by Modic classification. Frequency of microscopic calcification was significantly higher in degenerated disc than normal cadaveric (54.4% vs. 6.7%) and was higher in Modic type III than type I (III: 95.0%, II: 57.4%, I: 13.0%), also prevalence of angiogenesis was significantly higher in patients than cadaveric discs (41.0% vs. 6.7%) and in calcified than noncalcified discs (59.2% vs. 19.5%) (P < 0.001). There was no relationship between disc calcification and patients' gender and level of discectomy. Disc nucleus pulposus microscopic calcification is a common event occurring in adult patients suffering from lumbar disc herniation. Mechanisms that link disc degeneration, angiogenesis, and calcification remain a focus for further researches that may be useful in future medical treatments before surgical treatment of lumbar disc herniation.
    Spine 03/2010; 35(8):881-6. · 2.16 Impact Factor
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    ABSTRACT: It is important to find out the skull's anatomic indices with computed tomography (CT), especially the skull's dimensions according to the patients age and sex, because it can give important results in neurosurgery. We will also describe the skull's parameters among the Kerman population. Of the 2000 CT scans taken after head trauma injury in Kerman province from June 2002 to September 2006, we analyzed 1034 good quality films. The most frequent skull dimensions were measured on each film, and the data were computed and analyzed to assess the cranial indices in various ages and sexes. Two types of classifications were carried out: classic method, which uses cranial indices, and posterior fossa angle dimensions as an alternative method. Skull dimensions were statistically analyzed between groups, and any difference greater than 0.05 was considered significant. Of the 1034 films, 871 films belonged to the men and 184 to the women at age older than 5 years and younger than 70 years. Most of the CT films belonged to the patients with age older than 20 years and younger than 40 years in both sexes. Although the rates of various skull types were different according to the method of classification, the most frequent skull type was dolichocephalic followed by mesocephalic and brachycephalic in both sexes. In addition, in both sexes, the frequency of dolichocephaly was greater in children than adults, but brachycephaly was more frequent in adults than children. With CT scans as an accurate and suitable source of anthropometric evaluation of body dimensions, we found that, in our population, the most frequent skull type is dolichocephalic followed by mesocephalic, which seems to be closer to the Anglo-Saxon population considering the rates of dolichocephaly and mesocephaly.
    The Journal of craniofacial surgery 04/2009; 20(2):545-50. · 0.81 Impact Factor
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    ABSTRACT: In the present study we evaluated the in vitro cytotoxic activity of aqueous and methanolic extract of T. polium . In order to evaluate, first we established a new glioblastoma multiforme cell line, which was designated as REYF-1 cell. Cytotoxic activity of the extracts was evaluated on this cell line using both MTT assay and clonogenic cell assay. Present results show that methanolic extract of T. polium exhibits dose dependant cytotoxic effect. The IC50 values of methanolic extract were 95 and 69 μg mL<sup>-1</sup> using MTT assay and Clonogenic assay, respectively. The IC50 for aqueous extract was 1400 μg mL<sup>-1</sup>. These findings show a cytotoxic activity of T. polium methanolic extract on glioblastoma multiforme cells in vitro . Further studies need to be done to find out the active compound(s) of this plant as a cytotoxic agent.
    International Journal of Pharmacology 05/2007; · 1.20 Impact Factor
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    ABSTRACT: Some studies have been performed on the effects of exogenous and endogenous opioids on cerebral blood flow. We investigated the effects of morphine on Cerebral Blood Flow (CBF) under normal, ischemic and reperfusion states and its neuroprotective effects after induced cerebral ischemia. Twenty male rabbits were divided in to two groups. At first CBF was measured in anesthetized rabbits as the baseline, then morphine (2 mg kg<sup>-1</sup>) and normal saline were administered intravenously to the case and control groups, respectively. The CBF was measured again at 10, 25 and 40 min after injection. Ten minutes after injection of drugs, both common carotid vessels were occluded with microvascular clips and they were opened 25 min after injection (or 15 min after occlusion of vessels). Hippocampal subfield CA1 was studied for pathological findings of ischemia. Morphine decreased the mean CBF values at pre-ischemic stage without any changes in mean arterial blood pressure (MAP) but this reduction was not significant as compared to control group. In reperfusion stage, CBF values of both normal saline and morphine treated groups, were lower than baseline significantly (p<0.05), but this reduction was not significant between two groups. In assessment of neuroprotective effect and neuronal cell damage, there was not any significant difference between the two groups. Our results are in contrast with other studies which suggest morphine to have increasing or decreasing effect on CBF. This variation in results may be due to dosage and route of administration or site and method of CBF Measurement.
    International Journal of Pharmacology 06/2006; · 1.20 Impact Factor
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    ABSTRACT: Limited reports exist about intracranial incidental findings on computed tomography (CT) imaging. We studied the frequency of incidental findings on 3000 brain CT scans of trauma patients. Three thousands standard brain CT scans of trauma patients were evaluated for some incidental findings. Cisterna magna was evaluated in 1500 CT scans. In this study we found 30 incidental abnormalities that include 8 cases of tumor: 3 meningioma, 2 craniopharyngioma, 1 oligodendroglioma, 1 low-grade astrocytoma, and 1 medulloblastoma. Suspect osteoma was found in 3 cases. In 3 cases, abnormal calcification was found in pineal region, basal ganglia, and temporal horn area. Three suspect lipomas were found in midline and near midline of the brain. Arachnoid cyst was found in 7 cases and hydrocephaly in 3 cases. Large cisterna magna (>10 cm(3)) was found in 11 cases. Cisterna magna enlargement was the most common incidental finding and brain tumor and arachnoid cyst were next in frequency.
    Surgical Neurology 06/2005; 63(6):550-3; discussion 553. · 1.67 Impact Factor
  • Hossein Eskandary, Mohammad Saba, Touraj Yazdi
    Medical Hypotheses 02/2005; 65(5):997-8. · 1.18 Impact Factor
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    ABSTRACT: The complete or partial spontaneous disappearance of a cerebral arteriovenous malformation is rare. Spontaneous thrombosis in large arteriovenous malformations has been reported in only two cases. We report the case of a large arteriovenous malformation in a 17-year-old man, that thrombosed spontaneously after minor surgical manipulation and review the literature and some possible mechanisms for spontaneous thrombosis of arteriovenous malformation.
    Arch Iranian Med Archives of Iranian Medicine. 02/2003; 6(6):54-58.
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    Hossein Eskandary, Md @bullet, Nader Nowbari
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    ABSTRACT: Background– Certain trace elements such as zinc and copper have been studied in head injury patients. In this study, we decided to determine whether serum chromium concentrations were affected by the severity of a head injury. Methods– The study was conducted on 30 male patients aged from 10 to 30 years. Patients were divided into three groups based on the Glascow Coma Scale; 1-mild, 2-moderate and 3-severe head injury. Serum samples for chromium were obtained during the first four hours after head injury and analyzed by neutron activation analysis technique. Two independent sample t test was used to compare the mean serum concentration of chromium in different groups. Results– Mean ± SD of serum concentration of chromium was 1.41 ± 0.2 mg/L in the first, 1.58 ± 0.23 mg/L in the second and 1.42 ± 0.23 mg/L in the third group of patients. There was no significant difference among the three groups with respect to the serum concentration of chromium. Conclusion– To define the time-related changes of chromium and severity of the head injury, the total intake of chromium and other relevant factors should be considered in future studies.
    Arch Iranian Med Archives of Iranian Medicine. 08/2002; 5(5):162-165.
  • H. Eskandary, M. Shahabi, A. R. Asadi
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    ABSTRACT: Background:Autonomic disturbance can leads to blood flow changes that can be studied by various methods. Objective: To assess the blood flow changes in patients with severe carpal tunnel syndrome by laser Doppler flowmetry Methods:Ten patients with severe unilateral carpal tunnel syndrome confirmed by electrodiagnostic examination enrolled in this study. Patients comprised one man and nine women with mean age of 37 years, an average duration of symptoms for 29 weeks.Unaffected hand and little finger of affected hand were used as control. Skin blood flow was measured in neutral, flexed and extended positions of hands.
    01/2002;
  • H Eskandary, H Reihani Kermani
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    ABSTRACT: A pneumocele refers to an aerated sinus with either focal or generalized thinning of the bony sinus wall. Although the pathogenesis of a pneumocele is not yet known, it is presumed that increased intrasinusal pressure, due to a one-way valve between the nasal cavity and the affected sinus, is responsible for this condition. A 37-year-old man with frontal bossing, who underwent surgery for cosmetic reasons, is presented.
    International Journal of Oral and Maxillofacial Surgery 07/1999; 28(3):179-80. · 1.52 Impact Factor
  • H. Eskandary, H. Reihani Kermani
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    ABSTRACT: A pneumocele refers to an aerated sinus with either focal or generalized thinning of the bony sinus wall. Although the pathogenesis of a pneumocele is not yet known, it is presumed that increased intrasinusal pressure, due to a one-way valve between the nasal cavity and the affected sinus, is responsible for this condition. A 37-year-old man with frontal bossing, who underwent surgery for cosmetic reasons, is presented.
    International Journal of Oral and Maxillofacial Surgery 01/1999; 28(3):179-180. · 1.52 Impact Factor
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    H Eskandary, H R Kermani
    Annals of Saudi medicine 01/1998; 18(3):251-3. · 1.10 Impact Factor
  • H. Eskandary, M. Najafipour, H. Reyhani
    Clinical Neurology and Neurosurgery - CLIN NEUROL NEUROSURG. 01/1997; 99.
  • H Eskandary, A Hamzei, M T Yasamy
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    ABSTRACT: Six cases of foot drop following brain lesions in patients suffering from parasagittal pathology are reported. In three of these cases, foot drop was the first clinical presentation. The commonly held view that foot drop is mainly due to peripheral or spinal pathology, though correct, may lead to unnecessary investigation and delayed diagnosis.
    Surgical Neurology 02/1995; 43(1):89-90. · 1.67 Impact Factor

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