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We study the physiological roles of ubiquitin-dependent endocytic traffic of tyrosine kinase-coupled cell surface receptors by Cbl family ubiquitin ligases in stem cell homeostasis and how mutant Cbl proteins give rise to human leukemia. We explore targeting of ErbB2 and EGFR for degradation within the endocytic pathways as a potential therapeutic approach. Finally, we study the physiological roles of endocytic recyling with a focus on the four-member EHD family of recycling regulators.

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