Publications (3) View all
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Article: Tuberoz Skleroz Kompleksi, İki Olgu Sunumu
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ABSTRACT: Epiloia veya Bourneville hastalığı olarak da bilinen tuberoz skleroz, ektodermal ve mezodermal hücrelerin programlanmış hiperplazisinden kaynaklanan nörokutan bir sendromdur. Günümüzde tuberoz skleroz kompleksi terimi daha yaygın olarak kullanılmaktadır. Kompleks terimi, hastalığın genetik heterojenitesi yanında değişik multisistemik tutulumlarına da işaret etmektedir. Başlangıç yaşı ve şiddeti çok geniş varyasyonlar gösteren hastalığın klasik triadı; epilepsi, mental retardasyon ve adenoma sebaseum'dur. Tedavi etkilenen organa yöneliktir. Oldukça nadir görülen hastalık, kliniğimize başvuran iki farklı olgu nedeni ile tartışılmış ve uyarıcı olması gereken deri bulgularına ayrıntılı olarak yer verilmiştir. Tuberous sclerosis known as Epiloia and Bourneville's disease is a neurocutane syndrome, which is resulted from the programmed hyperplasia of ectodermal and mesodermal cells. The term tuberous sclerosis complex is now widely used. The term of the complex remarks variable multisystemic involvement and genetic heterogeneity of the disease. The disease showing different variations from the age of onset and the severity have classical triads ofepilepsy, mental retardation and adenoma sebaceum. The management of the disease is made according to the affected organ. This rarely seen disease was discussed because of the two different cases admitted to our clinics and detailed information about the cutaneous findings are given.İnönü Üniversitesi Tıp Fakültesi Dergisi. 01/2007; 14:123-127. -
Article: Psoriasis in childhood and adolescence: evaluation of demographic and clinical features
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ABSTRACT: Background: The present study was aimed to define the gender ratio, familial occurrence, age of onset, precipitating factors, clinical types, nail and joint involvement of psoriasis in childhood and adolescence in Turkey.Methods: A total of 61 children with psoriasis under 18 years old were evaluated retrospectively, for age, gender, age of disease onset, family history, concomitant disease, the clinical type of psoriasis, clinical localization, nail and joint involvement and treatment modalities.Results: Of the patients, 23 (37.70%) were boys and 38 (62.30%) were girls. Mean age was 9.28 ± 4.02 years in girls and 11.18 ± 3.85 years in boys (9.96 ± 4.03 years in all children). Mean age at the onset of the disease was 6.81 ± 4.11 years in girls and 7.03 ± 4.28 years in boys (6.89 ± 4.14 years in all patients). In 14 (23%) cases, a positive family history was detected. The most frequent probable triggering factors were upper respiratory tract infections (14.8%) and positive throat culture for A group ß-hemolytic streptococcus (21.3%). Frequency of emotional stress and psychiatric morbidity were 54% and 9.8%, respectively. The most frequent localizations at onset were trunk (44.3%), extremities (54.0%), and scalp (36.0%). Three children (4.9%) had a history of dissemination from psoriatic diaper rash. In total, 51 (83.6%) patients presented with psoriasis vulgaris, eight (13.1%) with generalized pustular psoriasis, and the remaining two (3.3%) with erythrodermic psoriasis.Conclusion: The incidence of psoriasis among dermatological patients in childhood and adolescence was 3.8%. The disease tends to appear earlier in girls than boys. The authors suggested that stress and upper respiratory infections are the most important triggering factors in childhood and adolescence psoriasis.Pediatrics International 11/2006; 48(6):525 - 530. · 0.63 Impact Factor -
Article: Melkersson Rosenthal Sendromu Ve Gebelik: Olgu Sunumu
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ABSTRACT: Melkersson Rosenthal Sendromu orofasiyal ödem, Bell Paralizisi ve dilde fissürler ile karakterizedir ve semptomlar tekrarlar. Hastaların çoğunluğu birkaç ay içinde tam olarak iyileşir. Bell paralizisi ile gebelik arasındaki ilişkiye ilk olarak 1830 da Sir Charles Bell dikkati çekmiştir. İzleyen yıllarda pek çok yazar gebelik ile Bell paralizisi insidansının arttığını bildiren yayınlar sundular. Bu yazıda 7 atağı olan, ataklarından 3'ü hamilelikleri döneminde ortaya çıkan Melkersson Rosenthal sendromlu bir olgu sunulmaktadır. Melkersson Rosenthal Syndrome(MRS) is a rare disorder consisting of the triad of persistent or recurrent orofacial edema, relapsing facial paralysis and fissured tongue. A case of MRS is described during pregnancy. The majority of patients recover completely in a few months. A possible association between Bell' palsy and pregnancy was noted by Sir Charles Bell in 1830 and many authors have since reported a higher incidence of Bell's palsy in pregnancy. Association between Melkersson Rosenthal syndrome and pregnancy has not previously been reported.İnönü Üniversitesi Tıp Fakültesi Dergisi. 01/2002; 9:119-121.
