Hajime Ishinaga

Publications (33) View all

• Article: Aggressive giant cell reparative granuloma of the nasal cavity.

  Hajime Ishinaga, Kazuya Otsu, Genshin Mouri, Kazuhiko Takeuchi
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  ABSTRACT: Giant cell reparative granuloma (GCRG) is an uncommon and nonneoplastic reactive tumor that involves the maxilla and mandible in the region of the head and neck. It is rare in the nasal cavity, and it might be misdiagnosed. We reported a very aggressive GCRG with intracranial invasion, which was treated surgically via a combined approach of a lateral rhinotomy with a craniotomy by bilateral coronal incision. The pathology was consistent with GCRG. A short literature review about diagnosis, clinical behavior, and treatment of this tumor entity is given.
  Case reports in otolaryngology. 01/2013; 2013:690194.
• Article: Descending necrotizing mediastinitis from deep neck infection.

  Hajime Ishinaga, Kazuya Otsu, Hiroshi Sakaida, Tomotaka Miyamura, Satoshi Nakamura, Masako Kitano, Hironori Tenpaku, Motoshi Takao, Masayoshi Kobayashi, Kazuhiko Takeuchi
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  ABSTRACT: This study aims to identify predisposing characteristics of descending necrotizing mediastinitis (DNM) arising from deep neck infection (DNI) and to determine appropriate therapeutic intervention strategies. We retrospectively reviewed 54 patients (male, n = 34; female, n = 20; mean age, 64.5 years) who had been treated at Mie University Hospital for DNI between April 2001 and October 2011. Eight of nine patients who developed DNM confirmed by computed tomography of the neck and chest, underwent mediastinal drainage (video-assisted thoracic surgical drainage, n = 6; mediastinoscopy-assisted drainage, n = 2). A patient developed uncontrolled acute respiratory distress syndrome after aggressive surgery, resulting in a mortality rate of 12 %. High blood CRP values, and the pharynx and tonsils as origins of infection were factors involved in the development of DNM arising from DNI. In conclusion, DNM remains a destructive and fatal disease that requires aggressive treatment including mediastinal exploration.
  Archives of Oto-Rhino-Laryngology 09/2012; · 1.29 Impact Factor
• Article: Long-term outcome of benign paroxysmal positional vertigo.

  M Sakaida, K Takeuchi, H Ishinaga, M Adachi, Y Majima
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  ABSTRACT: To clarify long-term outcome of benign paroxysmal positional vertigo (BPPV), 50 patients were followed up for a mean of 52 months. Overall recurrence rate by Kaplan-Meier estimation was 37% at 60 months. The patients with horizontal canal BPPV (n = 19) had a significantly higher recurrence rate (50%) at 60 months than those with posterior canal BPPV (n = 28; 26%). There was no significant association between recurrence rates and sex or age.
  Neurology 06/2003; 60(9):1532-4. · 8.31 Impact Factor
• Article: Histamine alters gene expression in cultured human nasal epithelial cells.

  K Takeuchi, C Kishioka, H Ishinaga, Y Sakakura, Y Majima
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  ABSTRACT: Airway epithelial cells produce cytokines and participate in the regulation of mucosal immunity. Although nasal epithelial cells express histamine receptors, it is not exactly known how nasal epithelial cells respond to histamine. The objective of this study was to examine whether histamine can alter the expression of the 4 genes encoding H1 receptor, IL-8, TNF-alpha, and ZO-1 tight-junction protein in cultured nasal epithelial cells. We added histamine or vehicle to cultured human nasal epithelial cells and extracted RNA from them 4 hours later. After DNase treatment, mRNAs of beta-actin, H1 receptor, IL-8, TNF-alpha, and ZO-1 tight-junction protein were amplified by using RT-PCR. Histamine significantly upregulated IL-8 mRNA expression and significantly downregulated ZO-1 mRNA expression. The latter effect was blocked by pretreatment with mepyramine, an H1 receptor antagonist. The reduction of ZO-1 mRNA by histamine may cause increased permeability of the mucosa during allergic reactions in the nose.
  Journal of Allergy and Clinical Immunology 03/2001; 107(2):310-4. · 11.00 Impact Factor
• Article: [Parathyroid function after total or subtotal thyroidectomy].

  A Kato, H Yamada, H Ishinaga
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  ABSTRACT: Postoperative parathyroid function was evaluated in 24 total thyroidectomy and 8 subtotal thyroidectomy patients seen by our department between January 1995 and July 1997. Parathyroid function was assessed by measuring the level of serum intact parathyroid hormon (intact-PTH). Hypoparathyroidism was avoided in 23 patients (95.8%) who received a total thyroidectomy and in 7 patients (87.5%) who received a subtotal thyroidectomy. Supplementary therapy for hypoparathyroidism was not required as long as the blood supply to more than two parathyroid glands was preserved. Half of the patients in this study did not require any postoperative supplementary therapy. Thus, the preservation of more than two parathyroid glands is essential for the prevention of hypoparathyroidism. In cases where the parathyroid glands had been resected, parathyroid gland transplantation were performed. In all cases, supplementary therapy was eventually no longer required. In two cases requiring supplementary therapy, a normal range of parathyroid activity was observed 30 months after surgery. The administration of vitamin D3 may suppress the recovery of parathyroid function in patients recieving parathyroid transplantations.
  Nippon Jibiinkoka Gakkai Kaiho 03/2000; 103(2):160-4.